'''Medoff''' is a surname. Notable people with the surname include:
*Jillian Medoff (born 1963), American author *Kara Medoff Barnett (born 1978), American business executive, theatre producer and arts administrator *Mark Medoff (1940–2019), American playwright, screenwriter, film and theatre director, actor and professor *Marshall Medoff (1945–2016), American economist *Rafael Medoff (born c. 1959), American historian
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