Masatake (written: , or ) is a masculine Japanese given name. Notable people with the name include:
- Inaba Masatake (稲葉 正武, 1769–1840), Japanese daimyō
- Masatake Kimura (木村 昌丈, born 1990), Japanese handball player
- Masatake Kuranishi (倉西 正武, 1924–2021), mathematician
- Masatake Okumiya (奥宮 正武, 1909–2007), Japanese aviator and historian
- Terauchi Masatake (寺内 正毅, 1852–1919), Japanese military officer, politician and Prime Minister of Japan