{{short description|Method to display data used in genetic analysis}} thumb|300px|An illustration of a Manhattan plot depicting several strongly associated risk loci A '''Manhattan plot''' is a type of plot, usually used to display data with a large number of data-points, many of non-zero amplitude, and with a distribution of higher-magnitude values. The plot is commonly used in genome-wide association studies (GWAS) to display significant SNPs.<ref name=East>{{cite journal|pmid=20581876|doi=10.1038/ng0710-558|year=2010|last1=Gibson|first1=Greg|title=Hints of hidden heritability in GWAS |volume=42|pages=558–560|journal=Nature Genetics|issue=7|s2cid=34546516 }}</ref>
It gains its name from the similarity of such a plot to the Manhattan skyline: a profile of skyscrapers towering above the lower level "buildings" which vary around a lower height.
==GWAS== In GWAS Manhattan plots, genomic coordinates are displayed along the ''x''-axis, with the negative logarithm of the association ''p''-value for each single nucleotide polymorphism (SNP) displayed on the ''y''-axis, meaning that each dot on the Manhattan plot signifies an SNP. Because the strongest associations have the smallest ''p''-values (e.g., 10<sup>−15</sup>), their negative logarithms will be the greatest (e.g., 15). The different colors of each block usually show the extent of each chromosome.
==References== {{Reflist}}
{{Commons category|Manhattan plot}}
Category:Statistical charts and diagrams Category:Genetic epidemiology Category:Single-nucleotide polymorphisms
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