{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein AF-9''' is a protein that in humans is encoded by the ''MLLT3'' gene.<ref name="pmid8506309">{{cite journal |vauthors=Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC | title = Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 10 | pages = 4631–5 |date=Jul 1993 | pmid = 8506309 | pmc = 46566 | doi =10.1073/pnas.90.10.4631 |display-authors=etal|bibcode=1993PNAS...90.4631N | doi-access = free }}</ref><ref name="pmid8414510">{{cite journal |vauthors=Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R | title = MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13 | journal = Oncogene | volume = 8 | issue = 11 | pages = 3085–92 |date=Nov 1993 | pmid = 8414510 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4300}}</ref>
==Interactions== MLLT3 has been shown to interact with BCOR.<ref name=pmid12776190>{{cite journal |last=Srinivasan |first=R Sathish |author2=de Erkenez Andrea C |author3=Hemenway Charles S |date=May 2003 |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor |journal=Oncogene |volume=22 |issue=22 |pages=3395–406 | issn = 0950-9232| pmid = 12776190 |doi = 10.1038/sj.onc.1206361 |doi-access=free }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} *{{cite journal |vauthors=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi= 10.1101/gad.14.14.1810| pmc=316791 }} *{{cite journal |vauthors=García-Cuéllar MP, Zilles O, Schreiner SA, etal |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. |journal=Oncogene |volume=20 |issue= 4 |pages= 411–9 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 |doi-access= free }} *{{cite journal |vauthors=Hemenway CS, de Erkenez AC, Gould GC |title=The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. |journal=Oncogene |volume=20 |issue= 29 |pages= 3798–805 |year= 2001 |pmid= 11439343 |doi= 10.1038/sj.onc.1204478 |doi-access= free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395–406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361 |doi-access= free }} *{{cite journal |vauthors=Erfurth F, Hemenway CS, de Erkenez AC, Domer PH |title=MLL fusion partners AF4 and AF9 interact at subnuclear foci. |journal=Leukemia |volume=18 |issue= 1 |pages= 92–102 |year= 2004 |pmid= 14603337 |doi= 10.1038/sj.leu.2403200 |doi-access= free }} *{{cite journal |vauthors=Montemurro L, Tonelli R, Fazzina R, etal |title=Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 96–7 |year= 2004 |pmid= 15381384 |doi= 10.1016/j.cancergencyto.2004.01.029 }} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }} *{{cite journal |vauthors=Martino V, Tonelli R, Montemurro L, etal |title=Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). |journal=Oncol. Rep. |volume=15 |issue= 1 |pages= 207–11 |year= 2006 |pmid= 16328057 |doi= 10.3892/or.15.1.207|doi-access=free }} {{refend}}
{{gene-9-stub}}
Category:Genes on human chromosome 9