MED6 — Mediated Wiki

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} {{Infobox protein family | Symbol = Med6 | Name = Med6 | image = | width = | caption = | Pfam = PF04934 | Pfam_clan = | InterPro = IPR007018 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} '''Mediator of RNA polymerase II transcription subunit 6''' is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the ''MED6'' gene.<ref name="pmid9234719" /><ref name="pmid9671713">{{cite journal | vauthors = Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD | title = Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 15 | pages = 8538–8543 | date = Aug 1998 | pmid = 9671713 | pmc = 21111 | doi = 10.1073/pnas.95.15.8538 | bibcode = 1998PNAS...95.8538J | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10001| access-date = }}</ref>

== Protein family ==

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.<ref name="pmid9234719">{{cite journal | vauthors = Lee YC, Min S, Gim BS, Kim YJ | title = A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans | journal = Mol. Cell. Biol. | volume = 17 | issue = 8 | pages = 4622–32 | date = August 1997 | pmid = 9234719 | pmc = 232315 | doi = 10.1128/MCB.17.8.4622}}</ref>

== Interactions ==

MED6 has been shown to interact with: * Cyclin-dependent kinase 8,<ref name = pmid14983011>{{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2339–44 | date = Feb 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100| bibcode = 2004PNAS..101.2339Y | doi-access = free }}</ref><ref name = pmid11416138>{{cite journal | vauthors = Wang G, Cantin GT, Stevens JL, Berk AJ | title = Characterization of mediator complexes from HeLa cell nuclear extract | journal = Mol. Cell. Biol. | volume = 21 | issue = 14 | pages = 4604–13 | date = Jul 2001 | pmid = 11416138 | pmc = 87123 | doi = 10.1128/MCB.21.14.4604-4613.2001 }}</ref><ref name = pmid10198638/><ref name = pmid11867769/> * Estrogen receptor alpha,<ref name = pmid11867769>{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 | bibcode = 2002PNAS...99.2642K | doi-access = free }}</ref> * MED21,<ref name = pmid9734358>{{cite journal | vauthors = Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–22 | date = Aug 1998 | pmid = 9734358 | doi = 10.1016/s1097-2765(00)80131-8| doi-access = free }}</ref> and * Thyroid hormone receptor alpha.<ref name = pmid10198638>{{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi = 10.1016/s1097-2765(00)80463-3| doi-access = free }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–222 | year = 1998 | pmid = 9734358 | doi = 10.1016/S1097-2765(00)80131-8 | doi-access = free }} * {{cite journal | vauthors = Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation | journal = Mol. Cell | volume = 3 | issue = 1 | pages = 97–108 | year = 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 | doi-access = free }} * {{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–370 | year = 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 | doi-access = free }} * {{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–828 | year = 1999 | pmid = 10235266 | doi = 10.1038/19783 | bibcode = 1999Natur.398..824R | s2cid = 204992765 }} * {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–832 | year = 1999 | pmid = 10235267 | doi = 10.1038/19789 | bibcode = 1999Natur.398..828N | s2cid = 23646963 }} * {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = Int. J. Cancer | volume = 83 | issue = 4 | pages = 456–464 | year = 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 | doi-access = free }} * {{cite journal | vauthors = Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG | title = Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis | journal = Nature | volume = 417 | issue = 6888 | pages = 563–567 | year = 2002 | pmid = 12037571 | doi = 10.1038/417563a | bibcode = 2002Natur.417..563G | s2cid = 4432077 }} * {{cite journal | vauthors = Kato Y, Habas R, Katsuyama Y, Näär AM, He X | title = A component of the ARC/Mediator complex required for TGF beta/Nodal signalling | journal = Nature | volume = 418 | issue = 6898 | pages = 641–646 | year = 2002 | pmid = 12167862 | doi = 10.1038/nature00969 | bibcode = 2002Natur.418..641K | s2cid = 4330754 }} * {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15123–15127 | year = 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 | doi-access = free }} * {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49671–49674 | year = 2004 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 | doi-access = free }} * {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5846–5851 | year = 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free }} * {{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2339–2344 | year = 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100 | bibcode = 2004PNAS..101.2339Y | doi-access = free }} * {{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Mol. Cell | volume = 14 | issue = 5 | pages = 685–691 | year = 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 | doi-access = free }} * {{cite journal | vauthors = Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D | title = PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator | journal = Mol. Cell | volume = 18 | issue = 1 | pages = 83–96 | year = 2005 | pmid = 15808511 | doi = 10.1016/j.molcel.2005.02.034 | doi-access = free }} {{refend}}

== External links == * {{UCSC genome browser|MED6}} * {{UCSC gene details|MED6}}

Category:Protein families