{{Infobox protein family | Symbol = Med29 | Name = Med29 | image = | width = | caption = | Pfam = PF11568 | Pfam_clan = | InterPro = IPR021018 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} '''Mediator of RNA polymerase II transcription subunit 29''' ('''Med29''') is a transcription suppressor that in humans is encoded by the MED29 gene.<ref name="pmid15555573">{{cite journal |vauthors=Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, etal | title=IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. | journal=Biochem Biophys Res Commun | year= 2004 | volume= 325 | issue= 4 | pages= 1330–8 | pmid=15555573 | doi=10.1016/j.bbrc.2004.10.159 }}</ref> It represents subunit MED29 of the Mediator complex.
Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the ''Drosophila melanogaster'' Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.<ref name="pmid15896743">{{cite journal |vauthors=Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW | title = The mammalian Mediator complex and its role in transcriptional regulation | journal = Trends Biochem. Sci. | volume = 30 | issue = 5 | pages = 250–5 |date=May 2005 | pmid = 15896743 | doi = 10.1016/j.tibs.2005.03.002 }}</ref>
== See also == *Mediator
==References== {{reflist}} {{InterPro content|IPR021018}}
Category:Protein families