MED19

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}}

'''Mediator complex subunit 19''' ('''Med19''') is a protein that in humans is encoded by the MED19 gene. <ref name="entrez"> {{cite web | title = Entrez Gene: Mediator complex subunit 19 | url = https://www.ncbi.nlm.nih.gov/gene/219541 | access-date = 2018-02-06 }}</ref>

==Function==

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

== See also == *Mediator

== References ==

== Further reading ==

{{refbegin | 2}} *{{cite journal |vauthors=Ding N, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Boyer TG |title=MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression |journal=J. Biol. Chem. |volume=284 |issue=5 |pages=2648–56 |year=2009 |pmid=19049968 |pmc=2631966 |doi=10.1074/jbc.M806514200 |doi-access=free }} *{{cite journal |vauthors=Li LH, He J, Hua D, Guo ZJ, Gao Q |title=Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro |journal=Cancer Chemother. Pharmacol. |volume=68 |issue=1 |pages=207–15 |year=2011 |pmid=20890603 |doi=10.1007/s00280-010-1468-9 |s2cid=19531562 }} *{{cite journal |vauthors=Chen L, Liang Z, Tian Q, Li C, Ma X, Zhang Y, Yang Z, Wang P, Li Y |title=Overexpression of LCMR1 is significantly associated with clinical stage in human NSCLC |journal=J. Exp. Clin. Cancer Res. |volume=30 |pages=18 |year=2011 |issue=1 |pmid=21306606 |pmc=3045976 |doi=10.1186/1756-9966-30-18 |doi-access=free }} *{{cite journal |vauthors=Zou SW, Ai KX, Wang ZG, Yuan Z, Yan J, Zheng Q |title=The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells |journal=Acta Pharmacol. Sin. |volume=32 |issue=3 |pages=354–60 |year=2011 |pmid=21372827 |pmc=4002777 |doi=10.1038/aps.2010.223 }} *{{cite journal |vauthors=Zhang H, Jiang H, Wang W, Gong J, Zhang L, Chen Z, Ding Q |title=Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growth |journal=Urol. Oncol. |volume=30 |issue=6 |pages=920–7 |year=2012 |pmid=21478038 |doi=10.1016/j.urolonc.2010.10.003 }} *{{cite journal |vauthors=Sun M, Jiang R, Li JD, Luo SL, Gao HW, Jin CY, Shi DL, Wang CG, Wang B, Zhang XY |title=MED19 promotes proliferation and tumorigenesis of lung cancer |journal=Mol. Cell. Biochem. |volume=355 |issue=1–2 |pages=27–33 |year=2011 |pmid=21519921 |doi=10.1007/s11010-011-0835-0 |s2cid=24675844 }} *{{cite journal |vauthors=Wang T, Hao L, Feng Y, Wang G, Qin D, Gu G |title=Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phase |journal=Oncol. Res. |volume=19 |issue=5 |pages=193–201 |year=2011 |pmid=21542455 |doi= 10.3727/096504011x12970940207760|doi-access=free }} *{{cite journal |vauthors=Ji-Fu E, Xing JJ, Hao LQ, Fu CG |title=Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells |journal=Mol. Biol. Rep. |volume=39 |issue=4 |pages=3675–81 |year=2012 |pmid=21732059 |doi=10.1007/s11033-011-1142-2 |s2cid=1788019 }} *{{cite journal |vauthors=Cui X, Xu D, Lv C, Qu F, He J, Chen M, Liu Y, Gao Y, Che J, Yao Y, Yu H |title=Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells |journal=BMB Rep |volume=44 |issue=8 |pages=547–52 |year=2011 |pmid=21871180 |doi= 10.5483/bmbrep.2011.44.8.547|doi-access=free }}