{{Short description|Plugin used by web browsers to display the 3D structure of molecules}} {{Multiple issues| {{more footnotes|date=July 2014}} {{primary sources|date=July 2014}} }} {{Infobox Software |name = MDL Chime |logo = |screenshot = |caption = |collapsible = |author = Elsevier |developer = Symyx Technologies |released = {{Start date|1996}} (0.9 Beta) <br/> {{Start date|1997}} (1.0 Full release) <ref>{{Cite web|url=https://www.umass.edu/microbio/chime/chimvers.htm|title = Chime Version History}}</ref> |latest release version = 2.6 SP7 |latest release date = {{Start date and age|2007|07|31}} |latest preview version = |latest preview date = <!-- {{Start date and age|YYYY|MM|DD}} --> |programming language = |operating system = Classic Mac OS, Microsoft Windows |platform = Internet Explorer, Mozilla Firefox |size = |language = |genre = |license = |website = http://accelrys.com/products/collaborative-science/biovia-discovery-studio/ }} '''MDL Chime''' was a free plugin used by web browsers to display the three-dimensional structures of molecules.<ref>{{cite journal | first1=Liz | last1=Dorland | title=News from Online: What's New with Chime? | journal=J. Chem. Educ. | year=2002 | volume=79 | issue=7 | page=778 | doi=10.1021/ed079p778| bibcode=2002JChEd..79..778D }}</ref> and was based on the RasMol code.<ref>{{cite journal | first1=John | last1=Hodgson | title=GlaxoWellcome and MDL become entangled in the Web | journal = Nature Biotechnology | volume=14 | page=690 | year=1996 | issue=6 | doi=10.1038/nbt0696-690| s2cid=32321207 | doi-access=free }}</ref>
==Plug-in== Chime was used by a wide range of biochemistry web sites for the visualization of macromolecules, many of which were linked to the ''World Index of Molecular Visualization Resources'' MolVisIndex.Org. Chime was also used until 2006 at the Protein Data Bank (PDB) to examine structures stored there.
Although available in 1996 in both Windows 95 and classic Mac OS versions for both Netscape and Internet Explorer browsers, development of Chime did not follow the move to Mac OS X for the Mac and support for Windows-based browsers other than Internet Explorer was limited (although it works well in Mozilla Firefox). One significant feature added in 1997 was the ability to display spectroscopic data in the form of the IUPAC JCAMP-DX protocols. Apart from this, most subsequent updates were for the installation package to follow the development of Windows and Internet Explorer. Accelrys announced in 2012 that Chime was no longer supported and would remain available for download until the end of 2012.<ref> {{citation | title= CHIME - No Fee | url= http://accelrys.com/products/informatics/cheminformatics/chime/no-fee.php | archive-url= https://web.archive.org/web/20120424141325/http://accelrys.com/products/informatics/cheminformatics/chime/no-fee.php | url-status= dead | archive-date= 2012-04-24 }} </ref> Chime was part of the ISIS product line acquired by Symyx Technologies from scientific publisher Elsevier in October 2007. Now Chime is owned by Dassault Systèmes BIOVIA (formerly Accelrys), and has been merged into Discovery Studio, but no longer exists as a free browser plugin.
Chime largely has been superseded by Jmol,<ref name=Herraez2006>{{citation |last= Herráez |first= A |year= 2006 |title= Biomolecules in the Computer: Jmol to the Rescue |journal= Biochemistry and Molecular Biology Education |volume= 34 |issue= 4 |pages= 255–61 |doi= 10.1002/bmb.2006.494034042644 |pmid= 21638687 |s2cid= 36319720 |url= https://eric.ed.gov/ERICWebPortal/recordDetail?accno=EJ759053 |doi-access= free }}</ref> a non-proprietary open-source Java molecular visualization application and JavaScript applet that has maintained most Chime command compatibility while adding numerous features.
==See also== * List of molecular graphics systems * ISIS/Draw * Molecular graphics * Discovery Studio
==References== {{Reflist}}
==External links== * [https://proteopedia.org/wiki/index.php/Chime#Screen_Capture_of_Chime_in_Action Screen Capture of Chime in Action]. * [https://web.archive.org/web/20110404042538/http://accelrys.com/products/informatics/cheminformatics/chime/no-fee.php Accelrys Chime] * [http://download.accelrys.com/downloads/6644401fa62eb8c7d66361cb771e806e/SymyxChime26SP8.exe: Chime Download]{{dead link|date=May 2017 |bot=InternetArchiveBot |fix-attempted=yes }} * [https://web.archive.org/web/20121227105257/http://www.rcsb.org/pdb/home/home.do RCSB Protein Data Bank] * [http://molviz.org MolviZ.Org: Molecular Visualization Resources] with rich collection of molecules * [http://webpages.dcu.ie/~pratta/ Dublin City University CHIME and Jmol Pages]
Category:Molecular geometry