{{Short description|Protein-coding gene in the species Homo sapiens}} {{protein |name=MAM domain containing glycosylphosphatidylinositol anchor 2 |caption= |image= |width= |HGNCid=19835 |Symbol=MDGA2 |AltSymbols=MAMDC1 |EntrezGene=161357 |OMIM = 611128 |RefSeq=NM_182830 |UniProt= |PDB= |ECnumber= |Chromosome=14 |Arm=q |Band=21.2 |LocusSupplementaryData= }}
'''''MDGA2''''' (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called ''MAMDC1''.<ref>{{Cite web | title = MDGA2 Gene — GeneCards | publisher = Weizmann Institute of Science | date = 2008-09-08 | url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=MDGA2 }}</ref> ''MDGA2'' is located on chromosome 14.
The gene has a homologue in rat and mouse, ''Mdga2'',<ref>{{Cite web | url = http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=735131 | title = Rat Genome Database: Mdga2 ( Rattus norvegicus ) | publisher = Medical College of Wisconsin | accessdate = 2008-11-14 }}</ref> and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.<ref>{{Cite journal | vauthors = Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD | title = Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization | journal = Molecular and Cellular Neuroscience | volume = 25 | issue = 2 | pages = 263–264 |date=February 2004 | doi = 10.1016/j.mcn.2003.10.016 | pmid = 15019943 | s2cid = 25186151 }}</ref>
There are several variants in the human gene,<ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/variation/view/?q=161357[geneid] | title = SNP linked to Gene MDGA2 | publisher = NCBI }}</ref> and a genome-wide association study has pointed to that single-nucleotide polymorphisms in ''MDGA2'' is associated with neuroticism.<ref>{{Cite journal | title = 18762592 | vauthors = van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D | journal = Archives of General Psychiatry | volume = 65 | issue = 9 | pages = 1062–1071 |date=September 2008 | pmid = 18762592 | url = http://archpsyc.ama-assn.org/cgi/content/full/65/9/1062 | doi = 10.1001/archpsyc.65.9.1062 | doi-access = | url-access = subscription }}</ref> However, a more recent study has failed to replicate that finding.<ref>{{Cite journal|last1=Hettema|first1=John M.|last2=Oord|first2=Edwin J.C.G. van den|last3=An|first3=Seon-Sook|last4=Kendler|first4=Kenneth S.|last5=Chen|first5=Xiangning|title=Follow-up association study of novel neuroticism gene MAMDC1|url=https://dx.doi.org/10.1097/ypg.0b013e32832cec22|journal=Psychiatric Genetics|volume=19|issue=4|pages=213–214|doi=10.1097/ypg.0b013e32832cec22|pmc=2844892|pmid=19440164|year=2009}}</ref>
== References == {{Reflist}}
Category:Genes on human chromosome 14