{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox gene}} '''MyoD family inhibitor''' is a protein that in humans is encoded by the ''MDFI'' gene.<ref name="pmid9250874">{{cite journal | vauthors = Kraut N | title = The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17 | journal = Mamm Genome | volume = 8 | issue = 8 | pages = 618–9 | date = Sep 1997 | pmid = 9250874 | doi = 10.1007/s003359900517 | s2cid = 25160364 }}</ref><ref name="pmid17289077">{{cite journal | vauthors = Wang Q, Young TM, Mathews MB, Pe'ery T | title = Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription | journal = J Mol Biol | volume = 367 | issue = 3 | pages = 630–46 | date = Mar 2007 | pmid = 17289077 | pmc = 1868487 | doi = 10.1016/j.jmb.2007.01.020 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MDFI MyoD family inhibitor| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4188}}</ref>
== Function ==
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.<ref name="entrez" />
== Interactions ==
MDFI has been shown to interact with: * C9orf86,<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network|author-link30=Huda Zoghbi | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R| s2cid = 4427026}}</ref> * GNAI2,<ref name = pmid16189514/> * MyoD,<ref name = pmid8797820>{{cite journal | vauthors = Chen CM, Kraut N, Groudine M, Weintraub H | title = I-mf, a novel myogenic repressor, interacts with members of the MyoD family | journal = Cell | volume = 86 | issue = 5 | pages = 731–41 | date = Sep 1996 | pmid = 8797820 | doi = 10.1016/s0092-8674(00)80148-8| s2cid = 16252710 | doi-access = free }}</ref> * Myogenin,<ref name = pmid8797820/> and * SIX1.<ref name = pmid16189514/>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Chen CM, Kraut N, Groudine M, Weintraub H | title = I-mf, a novel myogenic repressor, interacts with members of the MyoD family. | journal = Cell | volume = 86 | issue = 5 | pages = 731–41 | year = 1996 | pmid = 8797820 | doi = 10.1016/S0092-8674(00)80148-8 | s2cid = 16252710 | doi-access = free }} * {{cite journal | vauthors = Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M | title = Requirement of the mouse I-mfa gene for placental development and skeletal patterning. | journal = EMBO J. | volume = 17 | issue = 21 | pages = 6276–88 | year = 1999 | pmid = 9799236 | pmc = 1170953 | doi = 10.1093/emboj/17.21.6276 }} * {{cite journal | vauthors = Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ | title = Inhibition of Tcf3 binding by I-mfa domain proteins. | journal = Mol. Cell. Biol. | volume = 21 | issue = 5 | pages = 1866–73 | year = 2001 | pmid = 11238923 | pmc = 86756 | doi = 10.1128/MCB.21.5.1866-1873.2001 }} * {{cite journal | vauthors = Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L | title = Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1. | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52763–72 | year = 2004 | pmid = 14530267 | doi = 10.1074/jbc.M309610200 | doi-access = free }} * {{cite journal | vauthors = Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K, Aruga J | title = Myogenic repressor I-mfa interferes with the function of Zic family proteins. | journal = Biochem. Biophys. Res. Commun. | volume = 320 | issue = 1 | pages = 233–40 | year = 2004 | pmid = 15207726 | doi = 10.1016/j.bbrc.2004.05.158 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | s2cid = 13709685 | doi-access = free }} {{refend}}
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