{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''C-jun-amino-terminal kinase-interacting protein 2''' is a protein or the name of the gene that encodes it.<ref name="pmid10490659">{{cite journal |vauthors=Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ | title = The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins | journal = Mol Cell Biol | volume = 19 | issue = 10 | pages = 7245–54 |date=February 2000 | pmid = 10490659 | pmc = 84717 | doi = 10.1128/mcb.19.10.7245}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23542| access-date = }}</ref> The gene is also known as Islet-Brain-2 (IB2).
This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses,<ref>{{ cite journal |vauthors=Giza J, etal | title= Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. | journal= J. Neurosci. | volume= 30| issue= 44| pages= 14805–16 | year= 2010 | pmid= 21048139 | doi= 10.1523/JNEUROSCI.1161-10.2010 | pmc=3200367}}</ref> and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.<ref name="entrez" />
==Interactions== MAPK8IP2 has been shown to interact with MAP3K10,<ref name=pmid10490659 /> Mitogen-activated protein kinase 9,<ref name=pmid10490659/> LRP2,<ref name=pmid10827173>{{cite journal |last=Gotthardt |first=M |author2=Trommsdorff M |author3=Nevitt M F |author4=Shelton J |author5=Richardson J A |author6=Stockinger W |author7=Nimpf J |author8=Herz J |date=August 2000 |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction |journal=J. Biol. Chem. |volume=275 |issue=33 |pages=25616–24 | issn = 0021-9258| pmid = 10827173 |doi = 10.1074/jbc.M000955200 |doi-access=free }}</ref><ref name=pmid12508107>{{cite journal |last=Petersen |first=Helle Heibroch |author2=Hilpert Jan |author3=Militz Daniel |author4=Zandler Valerie |author5=Jacobsen Christian |author6=Roebroek Anton J M |author7=Willnow Thomas E |date=February 2003 |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule |journal=J. Cell Sci. |volume=116 |issue=Pt 3 |pages=453–61 | issn = 0021-9533| pmid = 12508107 |doi=10.1242/jcs.00243 |doi-access=free }}</ref> LRP1,<ref name=pmid10827173/> MAPK8IP3,<ref name=pmid10629060>{{cite journal |last=Kelkar |first=N |author2=Gupta S |author3=Dickens M |author4=Davis R J |date=February 2000 |title=Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 |journal=Mol. Cell. Biol. |volume=20 |issue=3 |pages=1030–43 | issn = 0270-7306| pmid = 10629060 |doi=10.1128/MCB.20.3.1030-1043.2000 |pmc=85220 }}</ref> MAP3K12,<ref name=pmid10490659/> MAPK8IP1,<ref name=pmid10490659/> MAP2K7<ref name=pmid10490659/><ref name=pmid10756100>{{cite journal |last=Negri |first=S |author2=Oberson A |author3=Steinmann M |author4=Sauser C |author5=Nicod P |author6=Waeber G |author7=Schorderet D F |author8=Bonny C |date=March 2000 |title=cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein |journal=Genomics |volume=64 |issue=3 |pages=324–30 | issn = 0888-7543| pmid = 10756100 |doi = 10.1006/geno.2000.6129 }}</ref> and MAP3K11.<ref name=pmid10490659/>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }} *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }} *{{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }} *{{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |bibcode=1999Natur.402..489D |doi-access=free }} *{{cite journal |vauthors=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=10.1128/MCB.20.3.1030-1043.2000 | pmc=85220 }} *{{cite journal |vauthors=Negri S, Oberson A, Steinmann M, etal |title=cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein |journal=Genomics |volume=64 |issue= 3 |pages= 324–30 |year= 2000 |pmid= 10756100 |doi= 10.1006/geno.2000.6129 }} *{{cite journal |vauthors=Gotthardt M, Trommsdorff M, Nevitt MF, etal |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200 |doi-access= free }} *{{cite journal |vauthors=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors are intracellular signaling proteins |journal=Curr. Biol. |volume=11 |issue= 10 |pages= 793–7 |year= 2001 |pmid= 11378392 |doi=10.1016/S0960-9822(01)00232-9 |pmc=3216481|bibcode=2001CBio...11..793S }} *{{cite journal |vauthors=Taru H, Kirino Y, Suzuki T |title=Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27567–74 |year= 2002 |pmid= 12023290 |doi= 10.1074/jbc.M203713200 |doi-access= free}} *{{cite journal |vauthors=Buchsbaum RJ, Connolly BA, Feig LA |title=Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4073–85 |year= 2002 |pmid= 12024021 |doi=10.1128/MCB.22.12.4073-4085.2002 | pmc=133864 }} *{{cite journal |vauthors=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49111–9 |year= 2003 |pmid= 12244047 |doi= 10.1074/jbc.M205520200 |pmc=4266389 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ |title=The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10731–6 |year= 2003 |pmid= 12524447 |doi= 10.1074/jbc.M207324200 |doi-access= free }} *{{cite journal |vauthors=Collins JE, Goward ME, Cole CG, etal |title=Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22 |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Kristensen O, Guenat S, Dar I, etal |title=A unique set of SH3–SH3 interactions controls IB1 homodimerization |journal=EMBO J. |volume=25 |issue= 4 |pages= 785–97 |year= 2006 |pmid= 16456539 |doi= 10.1038/sj.emboj.7600982 | pmc=1383563 }} {{refend}}
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