MAP2K1IP1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Mitogen-activated protein kinase scaffold protein 1''' is a scaffold protein that in humans is encoded by the ''MAPKSP1'' gene.<ref name="pmid9733512">{{cite journal | vauthors = Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ | title = MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade | journal = Science | volume = 281 | issue = 5383 | pages = 1668–71 | date = Oct 1998 | pmid = 9733512 | doi = 10.1126/science.281.5383.1668 | bibcode = 1998Sci...281.1668S }}</ref><ref name="pmid15016825">{{cite journal | vauthors = Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M | title = The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling | journal = J. Biol. Chem. | volume = 279 | issue = 22 | pages = 23422–30 | date = May 2004 | pmid = 15016825 | doi = 10.1074/jbc.M401648200 | doi-access = free}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8649}}</ref>

== Function ==

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.<ref name="entrez" />

== Interactions ==

MAP2K1IP1 has been shown to interact with MAP2K1.<ref name=pmid9733512 /><ref name=pmid11266467>{{cite journal | vauthors = Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA | title = A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment | journal = J. Cell Biol. | volume = 152 | issue = 4 | pages = 765–76 | date = Feb 2001 | pmid = 11266467 | pmc = 2195784 | doi = 10.1083/jcb.152.4.765 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K | title = Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway | journal = Exp. Hematol. | volume = 27 | issue = 10 | pages = 1542–7 | year = 1999 | pmid = 10517496 | doi = 10.1016/S0301-472X(99)00094-6 | doi-access = }} * {{cite journal | vauthors = Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA | title = A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment | journal = J. Cell Biol. | volume = 152 | issue = 4 | pages = 765–76 | year = 2001 | pmid = 11266467 | pmc = 2195784 | doi = 10.1083/jcb.152.4.765 }} * {{cite journal | vauthors = Teis D, Wunderlich W, Huber LA | title = Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction | journal = Dev. Cell | volume = 3 | issue = 6 | pages = 803–14 | year = 2002 | pmid = 12479806 | doi = 10.1016/S1534-5807(02)00364-7 | doi-access = free }} * {{cite journal | vauthors = Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y | title = Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 47089–97 | year = 2003 | pmid = 12975377 | doi = 10.1074/jbc.M306002200 | doi-access = free }} * {{cite journal | vauthors = Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF | title = The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins | journal = Biochem. J. | volume = 378 | issue = Pt 2 | pages = 353–62 | year = 2004 | pmid = 14611647 | pmc = 1223961 | doi = 10.1042/BJ20030786 }} * {{cite journal | vauthors = Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ | title = Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 18 | pages = 6981–6 | year = 2004 | pmid = 15118098 | pmc = 406452 | doi = 10.1073/pnas.0305894101 | bibcode = 2004PNAS..101.6981V | doi-access = free }} * {{cite journal | vauthors = Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T | title = Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 30 | pages = 10984–9 | year = 2004 | pmid = 15263099 | pmc = 503730 | doi = 10.1073/pnas.0403435101 | bibcode = 2004PNAS..10110984K | doi-access = free }} * {{cite journal | vauthors = Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ | title = MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling | journal = J. Cell. Biochem. | volume = 94 | issue = 4 | pages = 708–19 | year = 2005 | pmid = 15547943 | doi = 10.1002/jcb.20344 | s2cid = 19060718 }} * {{cite journal | vauthors = Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD | title = The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals | journal = Mol. Cell. Biol. | volume = 25 | issue = 12 | pages = 5119–33 | year = 2005 | pmid = 15923628 | pmc = 1140582 | doi = 10.1128/MCB.25.12.5119-5133.2005 }} * {{cite journal | vauthors = Villegas SN, Njaine B, Linden R, Carri NG | title = Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways | journal = Brain Res. Bull. | volume = 71 | issue = 1–3 | pages = 116–26 | year = 2006 | pmid = 17113937 | doi = 10.1016/j.brainresbull.2006.08.014 | s2cid = 27498866 }} * {{cite journal | vauthors = Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA | title = p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis | journal = J. Cell Biol. | volume = 175 | issue = 6 | pages = 861–8 | year = 2006 | pmid = 17178906 | pmc = 2064696 | doi = 10.1083/jcb.200607025 }} * {{cite journal | vauthors = Brahma A, Dalby KN | title = Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer | journal = Arch. Biochem. Biophys. | volume = 460 | issue = 1 | pages = 85–91 | year = 2007 | pmid = 17254543 | pmc = 2853909 | doi = 10.1016/j.abb.2006.11.031 }} * {{cite journal | vauthors = Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ | title = RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility | journal = Mol. Cell. Biol. | volume = 27 | issue = 23 | pages = 8296–305 | year = 2007 | pmid = 17908799 | pmc = 2169169 | doi = 10.1128/MCB.00598-07 }} {{refend}}