MAGI2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2''' also known as '''membrane-associated guanylate kinase inverted 2''' (MAGI-2) and '''atrophin-1-interacting protein 1''' (AIP-1) is an enzyme that in humans is encoded by the ''MAGI2'' gene.<ref name="pmid10681527">{{cite journal |vauthors=Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H | title = Identification and characterization of a PDZ protein that interacts with activin type II receptors | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5485–92 |date=Mar 2000 | pmid = 10681527 | doi =10.1074/jbc.275.8.5485 | doi-access = free }}</ref><ref name="pmid9734811">{{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | doi =10.1093/dnares/5.3.169 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9863}}</ref>

== Function ==

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.<ref name="entrez"/>

==Interactions== MAGI2 has been shown to interact with ATN1<ref name=pmid9647693>{{cite journal |last=Wood |first=J D |author2=Yuan J |author3=Margolis R L |author4=Colomer V |author5=Duan K |author6=Kushi J |author7=Kaminsky Z |author8=Kleiderlein J J |author9=Sharp A H |author10=Ross C A |date=Jun 1998 |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins |journal=Mol. Cell. Neurosci. |volume=11 |issue=3 |pages=149–60 |location = United States| issn = 1044-7431| pmid = 9647693 |doi = 10.1006/mcne.1998.0677 |s2cid=20003277 |doi-access=free }}</ref> and PTEN (gene).

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Wood JD, Yuan J, Margolis RL, etal |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 |s2cid=20003277 |doi-access=free }} *{{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free }} *{{cite journal |vauthors=Ide N, Hata Y, Deguchi M, etal |title=Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 456–61 |year= 1999 |pmid= 10080919 |doi= 10.1006/bbrc.1999.0364 }} *{{cite journal |vauthors=Wu X, Hepner K, Castelino-Prabhu S, etal |title=Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4233–8 |year= 2000 |pmid= 10760291 |doi=10.1073/pnas.97.8.4233 | pmc=18208 |bibcode=2000PNAS...97.4233W |doi-access=free }} *{{cite journal |vauthors=Xu J, Paquet M, Lau AG, etal |title=beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41310–7 |year= 2001 |pmid= 11526121 |doi= 10.1074/jbc.M107480200 |doi-access= free }} *{{cite journal |vauthors=Vazquez F, Grossman SR, Takahashi Y, etal |title=Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48627–30 |year= 2002 |pmid= 11707428 |doi= 10.1074/jbc.C100556200 |doi-access= free }} *{{cite journal |vauthors=Nishimura W, Yao I, Iida J, etal |title=Interaction of synaptic scaffolding molecule and Beta -catenin. |journal=J. Neurosci. |volume=22 |issue= 3 |pages= 757–65 |year= 2002 |pmid= 11826105 |pmc=6758496 |doi= 10.1523/JNEUROSCI.22-03-00757.2002|doi-access=free }} *{{cite journal |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Yap CC, Muto Y, Kishida H, etal |title=PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 4 |pages= 1122–8 |year= 2003 |pmid= 12589829 |doi=10.1016/S0006-291X(03)00070-6 }} *{{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |bibcode=2003Sci...300..767S }} *{{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access=free }} *{{cite journal |vauthors=Evgrafov OV, Mersiyanova I, Irobi J, etal |title=Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 602–6 |year= 2004 |pmid= 15122254 |doi= 10.1038/ng1354 |doi-access= free }} *{{cite journal |vauthors=Franklin JL, Yoshiura K, Dempsey PJ, etal |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457–70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }} *{{cite journal |vauthors=Hu Y, Li Z, Guo L, etal |title=MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. |journal=Arch. Biochem. Biophys. |volume=467 |issue= 1 |pages= 1–9 |year= 2007 |pmid= 17880912 |doi= 10.1016/j.abb.2007.07.027 }} {{refend}} {{PDB Gallery|geneid=9863}}