{{Short description|Antihypertensive medication}} {{Use dmy dates|date=February 2024}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 415479203 | type = combo | image = Amlodipine.svg | image_class = skin-invert-image | alt = | image2 = Benazepril.svg | image_class2 = skin-invert-image | alt2 =
<!-- Combo data --> | component1 = Amlodipine | class1 = Calcium channel blocker | component2 = Benazepril | class2 = ACE inhibitor
<!-- Clinical data --> | tradename = Lotrel | Drugs.com = {{drugs.com|ppa|amlodipine-and-benazepril}} | DailyMedID = Amlodipine and benazepril | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = C09 | ATC_suffix = BB13
<!-- Legal status --> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> | legal_AU_comment = | legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> | legal_BR_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA_comment = | legal_DE = <!-- Anlage I, II, III or Unscheduled --> | legal_DE_comment = | legal_NZ = <!-- Class A, B, C --> | legal_NZ_comment = | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = <ref name="Lotrel FDA label">{{cite web | title=Lotrel- amlodipine besylate and benazepril hydrochloride capsule | work = DailyMed | publisher = U.S. National Library of Medicine | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=94ae6054-b7ae-4212-a567-4f803af8f2c7 | access-date=20 June 2021}}</ref> | legal_EU = | legal_EU_comment = | legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> | legal_UN_comment = | legal_status = <!-- For countries not listed above -->
<!-- Identifiers --> | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 357437-90-2 | PubChem = 5746247 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4676979 | KEGG = D11069 }}
<!-- Definition and medical uses --> '''Amlodipine/benazepril''', sold under the brand name '''Lotrel''' among others, is a fixed-dose combination medication used to treat high blood pressure.<ref name="Lotrel FDA label" /> It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor.<ref name="Lotrel FDA label"/> It may be used if a single agent is not sufficient.<ref name="Lotrel FDA label"/> It is taken by mouth.<ref name="Lotrel FDA label"/>
<!-- Side effects and mechanisms --> Common side effects include cough, dizziness, and swelling.<ref name="Lotrel FDA label"/> Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.<ref name="Lotrel FDA label"/> Use in pregnancy is not recommended.<ref name="Lotrel FDA label"/> Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.<ref name="Lotrel FDA label"/>
<!-- Society and culture --> The combination was approved for medical use in the United States in 1995.<ref name=MTM2019>{{cite web | author = Cerner Multum |title=Amlodipine and benazepril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/amlodipine-and-benazepril.html |website=Drugs.com |access-date=10 March 2019 |language=en}}</ref> It is available as a generic medication.<ref>{{cite book | vauthors = Bope ET, Kellerman RD |title=Conn's Current Therapy 2017 E-Book |date=2016 |publisher=Elsevier Health Sciences |isbn=978-0-323-44335-7 |page=124 |url=https://books.google.com/books?id=UitFDQAAQBAJ&pg=PT158 }}</ref> In 2023, it was the 186th most commonly prescribed medication in the United States, with more than 2{{nbsp}}million prescriptions.<ref name="Top 300">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Amlodipine; Benazepril Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AmlodipineBenazepril | access-date = 19 August 2025 }}</ref>
==Medical uses== It is used to treat high blood pressure.<ref name="Lotrel FDA label"/> It is not a first-line treatment.<ref>{{cite journal | vauthors = Faulkner MA, Hilleman DE | title = Amlodipine/benazepril: fixed dose combination therapy for hypertension | journal = Expert Opinion on Pharmacotherapy | volume = 2 | issue = 1 | pages = 165–178 | date = January 2001 | pmid = 11336577 | doi = 10.1517/14656566.2.1.165 | s2cid = 23021242 }}</ref>
== References == {{Reflist}}
{{ACE inhibitors}} {{Calcium channel blockers}} {{Portal bar|Medicine}}
{{DEFAULTSORT:Amlodipine Benazepril}} Category:Combination antihypertensive drugs Category:Drugs developed by Novartis Category:Prodrugs Category:Wikipedia medicine articles ready to translate