Live Wire or Livewire, in comics, may refer to:
- Live Wire (Marvel Comics), a Marvel Comics supervillain
- Live Wire (DC Comics), an alias of the Legion of Super-Heroes member Garth Ranzz, aka Lightning Lad
- Livewire (DC Comics), a DC Comics supervillainess
- Livewire (Valiant Comics), a Valiant Comics character
- Livewires (comics), a Marvel Comics series
- Livewire, a character from Savage Dragon and a member of the Vicious Circle[1]