<span class="plainlinks"></span>{{Short description|Fixed-dose combination of an anxiety medication and a anticholinergic drug}} {{Drugbox | verifiedrevid = 477497934 | type = combo
<!--Combo data--> | component1 = Chlordiazepoxide | class1 = Anxiolytic | component2 = Clidinium bromide | class2 = Antimuscarinic
<!--Clinical data--> | tradename = Librax, others | Drugs.com = {{drugs.com|cons|chlordiazepoxide-and-clidinium}} | MedlinePlus = a601036 | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = N | pregnancy_US_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Chlordiazepoxide / clidinium Use During Pregnancy | website=Drugs.com | date=18 September 2019 | url=https://www.drugs.com/pregnancy/chlordiazepoxide-clidinium.html | access-date=15 August 2020}}</ref> | pregnancy_category = | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> | legal_US = Schedule IV | legal_status = | routes_of_administration = By mouth | ATCvet = | ATC_prefix = A03 | ATC_suffix = CA02
<!--Identifiers--> | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 8015-20-1 | PubChem = 3080646 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2338393 | KEGG = D10247 <!--Chemical data--> }}
'''Chlordiazepoxide/clidinium bromide''' (marketed as '''Librax''' among others) is a fixed-dose combination medication used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.<ref>{{cite book | vauthors = Donnelly P |title=Nurse's Handbook of Combination Drugs |date=2010 |publisher=Jones and Bartlett Publishers |location=Sudbury, Mass. |isbn=978-0-7637-6549-1 |page=537 |edition=2nd | chapter = Gasterointestinal Drugs | chapter-url = https://books.google.com/books?id=JmcNmKrzwQMC&dq=Chlordiazepoxide%2Fclidinium+bromide&pg=PA537 }}</ref> It contains chlordiazepoxide and clidinium bromide. It helps relieve stomach spasms, abdominal cramps, and anxiety.<ref name="MedlinePlus">{{cite web|title=Librax|url=https://www.medlineplus.gov/druginfo/meds/a601036.html |publisher=MedlinePlus: US National library of medicine|access-date=31 May 2013}}</ref> Librax is a fixed ratio of these two medications and, as such, is not typically prescribed with an accompanying dosage, but rather directions on how many capsules to take per day. It comes in a capsule taken by mouth, usually three or four times daily, before meals and at bedtime.<ref name="MedlinePlus" /> Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class.<ref>{{cite web | url = https://reference.medscape.com/drug/librax-chlordiazepoxide-clidinium-999569 | work = MedScape | title = Chlordiazepoxide }}</ref> Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic,<ref>{{cite web | title = Clidinium | work = Drugs.com | url = https://www.drugs.com/monograph/clidinium.html }}</ref> a sub-class of a family of drugs known as anticholinergics. It treats IBS by decreasing gastrointestinal motility.
Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).<ref name="MedlinePlus" />
It was approved for medical use in the United States in 1966.<ref name="accessdata.fda.gov">{{cite web | title=Librax: FDA-Approved Drugs | website=U.S. Food and Drug Administration (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=012750 | access-date=15 August 2020}}</ref><ref name="Librax FDA label" /> It is available as a generic medication.<ref>{{cite web | title=Chlordiazepoxide hydrochloride and clidinium bromide: FDA-Approved Drugs | website=U.S. Food and Drug Administration (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=211421 | access-date=15 August 2020}}</ref>
== Medical uses == Chlordiazepoxide/clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders.<ref name="Librax FDA label" /> It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.<ref name="Librax FDA label">{{cite web | title=Librax- chlordiazepoxide hydrochloride and clidinium bromide capsule | website=DailyMed | date=31 May 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f99ebf66-f207-4a97-9666-4da1d72b061c | access-date=15 August 2020}}</ref>
==References== {{reflist}}
== External links == * {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/chlordiazepoxide%20mixture%20with%20clidinium%20bromide | archive-url = https://web.archive.org/web/20220111100642/https://druginfo.nlm.nih.gov/drugportal/name/chlordiazepoxide%20mixture%20with%20clidinium%20bromide | url-status = dead | archive-date = January 11, 2022 | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Chlordiazepoxide mixture with clidinium bromide }}
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{{DEFAULTSORT:Chlordiazepoxide Clidinium Bromide}} Category:Drugs acting on the gastrointestinal system and metabolism Category:Combination drugs Category:GABAA receptor positive allosteric modulators