{{Short description|Combination drug}} {{Infobox drug | drug_name = | type = combo | component1 = Chlorproguanil | class1 = Antimalarial drug | component2 = Dapsone | class2 = Antibiotic <!-- Clinical data --> | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = <!-- A/B1/B2/B3/C/D/X --> | pregnancy_US = <!-- A/B/C/D/X --> | pregnancy_category= | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_AU_comment = | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_UN = <!-- N I, II, III, IV / P I, II, III, IV--> | legal_NZ = <!--Class A, B, C --> | legal_status = Withdrawn | routes_of_administration = <!-- Identifiers --> | CAS_number = 209665-78-1 | ATCvet = | ATC_prefix = <!-- 'none' if uncategorised --> | ATC_suffix = | PubChem = | DrugBank = }} '''Chlorproguanil/dapsone''' (sold commercially as '''Lapdap''') was a fixed dose antimalarial combination containing chlorproguanil and dapsone,<ref name="pmid12614733">{{cite journal | vauthors = Lang T, Greenwood B | title = The development of Lapdap, an affordable new treatment for malaria | journal = The Lancet. Infectious Diseases | volume = 3 | issue = 3 | pages = 162–8 | date = March 2003 | pmid = 12614733 | doi = 10.1016/S1473-3099(03)00547-4 }}</ref> which act synergistically against malaria. The drug was withdrawn in 2008 following increasing evidence of toxicity in the form of haemolysis occurring in patients with G6PD deficiency.<ref name="pmid20599264">{{cite journal | vauthors = Luzzatto L | s2cid = 34866078 | title = The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics | journal = Lancet | volume = 376 | issue = 9742 | pages = 739–41 | date = August 2010 | pmid = 20599264 | doi = 10.1016/S0140-6736(10)60396-0 }}</ref>
== References == {{reflist}}
{{Antiprotozoal agent}}
{{DEFAULTSORT:Chlorproguanil dapsone}} Category:Antimalarial agents Category:Combination antiviral drugs Category:Withdrawn drugs {{antimicrobial-stub}}