{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Lymphocyte antigen 6E''' is a protein that in humans is encoded by the ''LY6E'' gene.<ref name="pmid8757598">{{cite journal | vauthors = Capone MC, Gorman DM, Ching EP, Zlotnik A | title = Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family | journal = J Immunol | volume = 157 | issue = 3 | pages = 969–73 | date = Sep 1996 | doi = 10.4049/jimmunol.157.3.969 | pmid = 8757598 | doi-access = free }}</ref><ref name="pmid8650192">{{cite journal | vauthors = Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z | title = RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 12 | pages = 5910–4 | date = Jul 1996 | pmid = 8650192 | pmc = 39161 | doi = 10.1073/pnas.93.12.5910 | doi-access = free | bibcode = 1996PNAS...93.5910M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4061}}</ref> Increased expression of ''Ly6E'' is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.<ref>{{Cite journal|last1=Luo|first1=Linlin|last2=McGarvey|first2=Peter|last3=Madhavan|first3=Subha|last4=Kumar|first4=Rakesh|last5=Gusev|first5=Yuriy|last6=Upadhyay|first6=Geeta|date=2016-02-03|title=Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome|journal=Oncotarget|doi=10.18632/oncotarget.7163|issn=1949-2553|pmid=26862846|volume=7|issue=10|pmc=4905465|pages=11165–93}}</ref> Ly6E is associated with drug resistance and tumor immune escape in breast cancer.<ref>{{Cite journal|last1=Hossiny|first1=Midrar A.|last2=Luo|first2=Linlin|last3=Frazier|first3=William R.|last4=Steiner|first4=Noriko|last5=Gusev|first5=Yuriy|last6=Kallakury|first6=Bhaskar|last7=Glasgow|first7=Eric|last8=Creswell|first8=Karen|last9=Madhavan|first9=Subha|last10=Kumar|first10=Rakesh|last11=Upadhyay|first11=Geeta|date=2016-04-11|title=Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance|url= |journal=Cancer Research|language=en|pages=3376–3386|doi=10.1158/0008-5472.CAN-15-2654|pmid=27197181|pmc=4910623|issn=0008-5472|volume=76|issue=11}}</ref> Further research is required to validate Ly6E for translation research. [http://www.telmarc.com/Documents/White%20Papers/133LY6.pdf]
== References == {{Reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB | title = A gain of novel tissue specificity in the human Ly-6 gene E48 | journal = J. Immunol. | volume = 159 | issue = 10 | pages = 4879–86 | year = 1997 | doi = 10.4049/jimmunol.159.10.4879 | pmid = 9366413 | doi-access = free }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG | title = Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1 | journal = J. Immunol. | volume = 160 | issue = 1 | pages = 197–208 | year = 1998 | doi = 10.4049/jimmunol.160.1.197 | pmid = 9551972 | doi-access = free }} * {{cite journal | vauthors = Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T | title = Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex | journal = J. Biol. Chem. | volume = 273 | issue = 20 | pages = 12301–6 | year = 1998 | pmid = 9575182 | doi = 10.1074/jbc.273.20.12301 | doi-access = free }} * {{cite journal | vauthors = Ding L, Shevach EM | title = Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen | journal = Immunology | volume = 104 | issue = 1 | pages = 28–36 | year = 2001 | pmid = 11576217 | pmc = 1783287 | doi = 10.1046/j.1365-2567.2001.01275.x }} * {{cite journal | vauthors = Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ | title = Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 946–52 | year = 2002 | pmid = 11784869 | pmc = 133557 | doi = 10.1128/MCB.22.3.946-952.2002 }} * {{cite journal | vauthors = de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH | title = Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma | journal = Int. J. Cancer | volume = 103 | issue = 6 | pages = 768–74 | year = 2003 | pmid = 12516096 | doi = 10.1002/ijc.10903 | s2cid = 42182637 }} {{refend}}
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