LHX3 — Mediated Wiki

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''LIM/homeobox protein Lhx3''' is a protein that in humans is encoded by the ''LHX3'' gene.<ref name="pmid10598593">{{cite journal |vauthors=Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ | title = Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties | journal = Mol Endocrinol | volume = 13 | issue = 12 | pages = 2212–25 |date=Jan 2000 | pmid = 10598593 | doi =10.1210/me.13.12.2212 | doi-access = }}</ref><ref name="pmid10717474">{{cite journal |vauthors=Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ | title = Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9 | journal = Gene | volume = 245 | issue = 2 | pages = 237–43 |date=May 2000 | pmid = 10717474 | doi =10.1016/S0378-1119(00)00025-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8022}}</ref>

== Function ==

''LHX3'' encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez" />

== Clinical significance ==

Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.<ref name="entrez" />

==Interactions== LHX3 has been shown to interact with Ldb1.<ref name="pmid9452425">{{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3152–7 |date=February 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 | doi-access = free }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | author=Zhadanov AB |title=Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues |journal=Dev. Dyn. |volume=202 |issue= 4 |pages= 354–64 |year= 1995 |pmid= 7626792 |doi= 10.1002/aja.1002020405 | author2=Bertuzzi S | author3=Taira M | last4=Dawid | first4=Igor B. | last5=Westphal | first5=Heiner |s2cid=36677316 }} *{{cite journal | author=Zhadanov AB |title=Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3 |journal=Genomics |volume=27 |issue= 1 |pages= 27–32 |year= 1995 |pmid= 7665181 |doi= 10.1006/geno.1995.1004 | author2=Copeland NG | author3=Gilbert DJ | last4=Jenkins | first4=Nancy A. | last5=Westphal | first5=Heiner |url=https://zenodo.org/record/1229689 }} *{{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=10.1074/jbc.273.6.3152 |doi-access=free }} *{{cite journal | author=Bach I |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 | author2=Rodriguez-Esteban C | author3=Carrière C | last4=Rodriguez-Esteban | first4=Concepción | last5=Carrière | first5=Catherine | last6=Bhushan | first6=Anil | last7=Krones | first7=Anna | last8=Rose | first8=David W. | last9=Glass | first9=Christopher K. |s2cid=22326394 }} *{{cite journal |vauthors=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159–67 |year= 2000 |pmid= 10593900 |doi=10.1074/jbc.274.51.36159 |doi-access=free }} *{{cite journal |vauthors=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336–42 |year= 2000 |pmid= 10788441 |doi=10.1074/jbc.275.18.13336 |doi-access= free}} *{{cite journal | author=Parker GE |title=The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23891–8 |year= 2000 |pmid= 10818088 |doi= 10.1074/jbc.M000377200 | author2=Sandoval RM | author3=Feister HA | last4=Bidwell | first4=JP | last5=Rhodes | first5=SJ |doi-access=free }} *{{cite journal | author=Netchine I |title=Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 182–6 |year= 2000 |pmid= 10835633 |doi= 10.1038/76041 | author2=Sobrier ML | author3=Krude H | last4=Krude | first4=Heiko | last5=Schnabel | first5=Dirk | last6=Maghnie | first6=Mohamed | last7=Marcos | first7=Elisabeth | last8=Duriez | first8=Bénédicte | last9=Cacheux | first9=Valère |s2cid=12358307 }} *{{cite journal |vauthors=Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ |title=Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 49–56 |year= 2000 |pmid= 10903894 |doi= 10.1006/bbrc.2000.3038 |bibcode=2000BBRC..274...49S }} *{{cite journal |vauthors=Sloop KW, Dwyer CJ, Rhodes SJ |title=An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36311–9 |year= 2001 |pmid= 11470784 |doi= 10.1074/jbc.M103888200 |doi-access= free }} *{{cite journal | author=Ostendorff HP |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors |journal=Nature |volume=416 |issue= 6876 |pages= 99–103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a | author2=Peirano RI | author3=Peters MA | last4=Schlüter | first4=Anne | last5=Bossenz | first5=Michael | last6=Scheffner | first6=Martin | last7=Bach | first7=Ingolf |bibcode=2002Natur.416...99O |s2cid=4426785 }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo |journal=Development |volume=130 |issue= 9 |pages= 1915–25 |year= 2003 |pmid= 12642495 |doi=10.1242/dev.00389 |s2cid=6211268 |doi-access= }} *{{cite journal | author=Kim SS |title=Clinical characteristics and molecular analysis of PIT1, PROP1, LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging |journal=Horm. Res. |volume=60 |issue= 6 |pages= 277–83 |year= 2004 |pmid= 14646405 |doi= 10.1159/000074245 | author2=Kim Y | author3=Shin YL | last4=Kim | first4=Gu-Hwan | last5=Kim | first5=Tae-Ue | last6=Yoo | first6=Han-Wook |s2cid=31256955 }} *{{cite journal | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207–9 |year= 2004 |pmid= 14714741 |doi= 10.1515/jpem.2003.16.9.1207|s2cid=45542882 }} *{{cite journal | author=West BE |title=Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor |journal=Endocrinology |volume=145 |issue= 11 |pages= 4866–79 |year= 2004 |pmid= 15271874 |doi= 10.1210/en.2004-0598 | author2=Parker GE | author3=Savage JJ | last4=Kiratipranon | first4=P | last5=Toomey | first5=KS | last6=Beach | first6=LR | last7=Colvin | first7=SC | last8=Sloop | first8=KW | last9=Rhodes | first9=SJ | doi-access=free }} *{{cite journal |vauthors=Parker GE, West BE, Witzmann FA, Rhodes SJ |title=Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 67–80 |year= 2005 |pmid= 15517599 |doi= 10.1002/jcb.20287 |s2cid=41303062 }} *{{cite journal | author=Sobrier ML |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279–84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003 | author2=Attié-Bitach T | author3=Netchine I | last4=Encha-Razavi | first4=F. | last5=Vekemans | first5=M. | last6=Amselem | first6=S. }} {{refend}}

== External links == * {{MeshName|LHX3+protein,+human}}

Category:Transcription factors Category:Genes on human chromosome 9