Keratin 34

{{Short description|Protein found in humans}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Keratin, type I cuticular Ha4''' is a protein that in humans is encoded by the ''KRT34'' gene.<ref name="pmid2431943">{{cite journal |vauthors=Heid HW, Werner E, Franke WW | title = The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins | journal = Differentiation | volume = 32 | issue = 2 | pages = 101–19 |date=Feb 1987 | pmid = 2431943 | doi =10.1111/j.1432-0436.1986.tb00562.x }}</ref><ref name="pmid9756910">{{cite journal |vauthors=Rogers MA, Winter H, Wolf C, Heck M, Schweizer J | title = Characterization of a 190-kilobase pair domain of human type I hair keratin genes | journal = J Biol Chem | volume = 273 | issue = 41 | pages = 26683–91 |date=Nov 1998 | pmid = 9756910 | doi = 10.1074/jbc.273.41.26683| doi-access = free }}</ref><ref name="pmid16831889">{{cite journal |vauthors=Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW | title = New consensus nomenclature for mammalian keratins | journal = J Cell Biol | volume = 174 | issue = 2 | pages = 169–74 |date=Jul 2006 | pmid = 16831889 | pmc = 2064177 | doi = 10.1083/jcb.200603161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KRT34 keratin 34| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3885}}</ref>

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.<ref name="entrez"/>

==See also== *34βE12 (keratin 903)

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Yu J, Yu DW, Checkla DM, etal |title=Human hair keratins. |journal=J. Invest. Dermatol. |volume=101 |issue= 1 Suppl |pages= 56S–59S |year= 1993 |pmid= 7686952 |doi= 10.1111/1523-1747.ep12362635}} *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 | pmc=1847948 |doi= 10.1038/msb4100134 }} *{{cite journal |vauthors=Raica M, Zylis D, Cîmpean AM |title=Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma. |journal=Romanian Journal of Morphology and Embryology |volume=46 |issue= 1 |pages= 11–5 |year= 2007 |pmid= 16286979 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Langbein L, Rogers MA, Winter H, etal |title=The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19874–84 |year= 1999 |pmid= 10391933 |doi= 10.1074/jbc.274.28.19874|doi-access=free }} {{refend}}