{{Short description|Professor of Statistical Genomics}} {{Infobox scientist | name = Jonathan Marchini | image = Jonathan Marchini.png | image_size = | alt = | caption = | birth_name = Jonathan Laurence Marchini | birth_date = | birth_place = Chichester | death_date = | death_place = | workplaces = {{Plainlist| * University of Oxford}} | alma_mater = {{Plainlist| * University of Exeter (BSc) * University of Oxford (DPhil)}} | thesis_title = The Statistical Analysis of Brain Images | thesis_year = 2002 | doctoral_advisor = Brian Ripley<ref>{{Cite journal|last1=Marchini|first1=J.|last2=Ripley|first2=B.|title= A New Statistical Approach to Detecting Significant Activation in Functional MRI. Molecular evolution|journal=NeuroImage|volume=12|issue=4|pages=366–80|year=2000|doi=10.1006/nimg.2000.0628|pmid=10988031|s2cid=54375337 }}</ref> | doctoral_students = | notable_students = | known_for = | awards = {{Plainlist| * Philip Leverhulme Prize {{small|(2013)}}<ref>{{cite web|url=https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2012%20prize%20winners%20+%20citations.pdf|title=Leverhulme website|access-date=2018-04-01|archive-url=https://web.archive.org/web/20180402225750/https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2012%20prize%20winners%20+%20citations.pdf|archive-date=2018-04-02}}</ref> }} | website = {{URL|https://jmarchini.org/}} }}
'''Jonathan Laurence Marchini''' (born 19 May 1973)<ref>{{cite web|title=Companies house record|url=https://beta.companieshouse.gov.uk/officers/aAcdxEeDlXelrWImuW9QQardioA/appointments}}</ref> is a Bayesian statistician and professor of statistical genomics<ref>{{cite web|title=Marchini website|url=http://www.stats.ox.ac.uk/~marchini/}}</ref> in the Department of Statistics at the University of Oxford, a tutorial fellow in statistics at Somerville College,<ref>{{cite web|title=Somerville website|url=https://www.some.ox.ac.uk/people/jonathan-marchini/}}</ref> Oxford and a co-founder and director of Gensci Ltd.<ref>{{cite web|title=Companies house record|url=https://beta.companieshouse.gov.uk/officers/aAcdxEeDlXelrWImuW9QQardioA/appointments}}</ref> He co-leads the Haplotype Reference Consortium.<ref>{{cite web|title=HRC website|url=http://www.haplotype-reference-consortium.org/}}</ref>
== Education ==
He obtained a Bachelor of Science degree in Pure Mathematics and Mathematical Statistics from Exeter University (1991–94).<ref>{{cite web|title=Somerville College Report|url=https://www.some.ox.ac.uk/wp-content/uploads/2015/07/Coll-Rep-web-7-Nov.pdf}}</ref> He then obtained a PGCE in Mathematics Education from the West Sussex Institute of Higher Education (1994–95). He completed his DPhil in the Department of Statistics at the University of Oxford supervised by Professor Brian Ripley (1998–2002).<ref>{{cite journal|last1=Marchini|first1=Jonathan L.|last2=Ripley|first2=Brian D.|title=A New Statistical Approach to Detecting Significant Activation in Functional MRI|journal=NeuroImage|date=October 2000|volume=12|issue=4|pages=366–380|doi=10.1006/nimg.2000.0628|pmid=10988031|s2cid=54375337 }}</ref>
== Career and research ==
Marchini spent three years working as a VSO volunteer teaching A-level Mathematics at Tosamaganga Secondary school, near Iringa, Tanzania, between September 1995 and September 1998.<ref>{{cite web|url=http://www.stats.ox.ac.uk/~marchini/vsopics.html|title=Photo album}}</ref>
From 2002 to 2005 he held a Wellcome Trust Training Fellowship in Mathematical Biology, under the supervision of Prof Lon Cardon and Prof Peter Donnelly.
In 2006 he was appointed as a university lecturer (associate professor) in statistical genomics in the Department of Statistics at the University of Oxford and a senior research fellow at Mansfield College. In 2007 he became an affiliated group leader at the Wellcome Trust Center of Human Genetics<ref>{{cite web|title=WTCHG website|url=http://www.well.ox.ac.uk/research-groups}}</ref> at the University of Oxford. In 2010 he was re-appointed until retirement <ref>{{cite web|url=http://www.ox.ac.uk/gazette/2010-2011/18november2010/notices/|title=Oxford Gazette link}}</ref>
In 2015 he was promoted to professor of statistical genomics<ref>{{cite web|url=http://www.ox.ac.uk/gazette/2014-2015/6november2014-no5076/notices/|title=Oxford Gazette link|access-date=2018-04-01|archive-date=2015-09-16|archive-url=https://web.archive.org/web/20150916145355/http://www.ox.ac.uk/gazette/2014-2015/6november2014-no5076/notices/}}</ref><ref>{{cite web|url=http://www.ox.ac.uk/gazette/2015-2016/1october2015-no5107/notices/|title=Oxford Gazette link}}</ref>
Marchini's research focusses on statistical genetics and population genetics, with a particular emphasis on methods development for genome-wide association studies. He has worked on haplotype estimation,<ref>{{cite journal|last1=O'Connell|first1=Jared|last2=Sharp|first2=Kevin|last3=Shrine|first3=Nick|last4=Wain|first4=Louise|author-link4=Louise Wain |last5=Hall|first5=Ian|last6=Tobin|first6=Martin|last7=Zagury|first7=Jean-Francois|last8=Delaneau|first8=Olivier|last9=Marchini|first9=Jonathan|title=Haplotype estimation for biobank-scale data sets|journal=Nature Genetics|date=6 June 2016|volume=48|issue=7|pages=817–820|doi=10.1038/ng.3583|pmid=27270105|pmc=4926957}}</ref><ref>{{cite journal|last1=O'Connell|first1=Jared|last2=Gurdasani|first2=Deepti|last3=Delaneau|first3=Olivier|last4=Pirastu|first4=Nicola|last5=Ulivi|first5=Sheila|last6=Cocca|first6=Massimiliano|last7=Traglia|first7=Michela|last8=Huang|first8=Jie|last9=Huffman|first9=Jennifer E.|last10=Rudan|first10=Igor|last11=McQuillan|first11=Ruth|last12=Fraser|first12=Ross M.|last13=Campbell|first13=Harry|last14=Polasek|first14=Ozren|last15=Asiki|first15=Gershim|last16=Ekoru|first16=Kenneth|last17=Hayward|first17=Caroline|last18=Wright|first18=Alan F.|last19=Vitart|first19=Veronique|last20=Navarro|first20=Pau|last21=Zagury|first21=Jean-Francois|last22=Wilson|first22=James F.|last23=Toniolo|first23=Daniela|last24=Gasparini|first24=Paolo|last25=Soranzo|first25=Nicole|last26=Sandhu|first26=Manjinder S.|last27=Marchini|first27=Jonathan|last28=Gibson|first28=Greg|title=A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness|journal=PLOS Genetics|date=17 April 2014|volume=10|issue=4|article-number=e1004234|doi=10.1371/journal.pgen.1004234|pmid=24743097|pmc=3990520 |doi-access=free }}</ref><ref>{{cite journal|last1=Delaneau|first1=Olivier|last2=Howie|first2=Bryan|last3=Cox|first3=Anthony J.|last4=Zagury|first4=Jean-François|last5=Marchini|first5=Jonathan|title=Haplotype Estimation Using Sequencing Reads|journal=The American Journal of Human Genetics|date=October 2013|volume=93|issue=4|pages=687–696|doi=10.1016/j.ajhg.2013.09.002|pmid=24094745|pmc=3791270 |bibcode=2013AmJHG..93..687D }}</ref><ref>{{cite journal|last1=Delaneau|first1=Olivier|last2=Zagury|first2=Jean-Francois|last3=Marchini|first3=Jonathan|title=Improved whole-chromosome phasing for disease and population genetic studies|journal=Nature Methods|date=1 January 2013|volume=10|issue=1|pages=5–6|doi=10.1038/nmeth.2307|pmid=23269371|bibcode=2013NatCB..10....5D |s2cid=205421216 }}</ref> genotype imputation,<ref>{{cite journal|last1=Howie|first1=Bryan N.|last2=Donnelly|first2=Peter|last3=Marchini|first3=Jonathan|last4=Schork|first4=Nicholas J.|title=A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies|journal=PLOS Genetics|date=19 June 2009|volume=5|issue=6|article-number=e1000529|doi=10.1371/journal.pgen.1000529|pmid=19543373|pmc=2689936 |doi-access=free }}</ref> genotype calling from arrays and sequencing, sparse tensor decomposition for RNA-seq datasets,<ref>{{cite journal|last1=Hore|first1=Victoria|last2=Viñuela|first2=Ana|last3=Buil|first3=Alfonso|last4=Knight|first4=Julian|last5=McCarthy|first5=Mark I|last6=Small|first6=Kerrin|last7=Marchini|first7=Jonathan|title=Tensor decomposition for multiple-tissue gene expression experiments|journal=Nature Genetics|date=1 August 2016|volume=48|issue=9|pages=1094–1100|doi=10.1038/ng.3624|pmid=27479908|pmc=5010142}}</ref> population structure,<ref>{{cite journal|last1=Marchini|first1=Jonathan|last2=Cardon|first2=Lon R|last3=Phillips|first3=Michael S|last4=Donnelly|first4=Peter|title=The effects of human population structure on large genetic association studies|journal=Nature Genetics|date=28 March 2004|volume=36|issue=5|pages=512–517|doi=10.1038/ng1337|pmid=15052271|doi-access=free |bibcode=2004NaGen..36..512M }}</ref> phenotype prediction and mixed models,<ref>{{cite journal|last1=Dahl|first1=Andrew|last2=Iotchkova|first2=Valentina|last3=Baud|first3=Amelie|last4=Johansson|first4=Åsa|last5=Gyllensten|first5=Ulf|last6=Soranzo|first6=Nicole|last7=Mott|first7=Richard|last8=Kranis|first8=Andreas|last9=Marchini|first9=Jonathan|title=A multiple-phenotype imputation method for genetic studies|journal=Nature Genetics|date=22 February 2016|volume=48|issue=4|pages=466–472|doi=10.1038/ng.3513|pmid=26901065|pmc=4817234}}</ref> gene–gene interactions<ref>{{cite journal|last1=Marchini|first1=Jonathan|last2=Donnelly|first2=Peter|last3=Cardon|first3=Lon R|title=Genome-wide strategies for detecting multiple loci that influence complex diseases|journal=Nature Genetics|date=27 March 2005|volume=37|issue=4|pages=413–417|doi=10.1038/ng1537|pmid=15793588|s2cid=5922358 }}</ref> and brain imaging genetics.<ref>{{cite bioRxiv|last1=Elliott |first1=Lloyd T. |last2=Sharp |first2=Kevin |last3=Alfaro-Almagro |first3=Fidel |last4=Shi |first4=Sinan |last5=Miller |first5=Karla |last6=Douaud |first6=Gwenaëlle |last7=Marchini |first7=Jonathan |last8=Smith |first8=Stephen |title=Genome-wide association studies of brain structure and function in the UK Biobank |date=2018 |biorxiv=10.1101/178806}}</ref>
He was a member of the analysis team for the International HapMap Project, the Wellcome Trust Case-Control Consortium, the 1000 Genomes Project and the UK10K Project. His research group was responsible for the haplotype estimation and genotype imputation for the UK Biobank dataset. He co-leads the Haplotype Reference Consortium.<ref>{{cite web|title=HRC website|url=http://www.haplotype-reference-consortium.org/}}</ref>
He has been an ISI Highly Cited Researcher from 2014-2018<ref>{{cite web|title=ISI Highly Cited Researchers|date=7 October 2025 |url=https://clarivate.com/hcr/}}</ref>
He has acted as an expert witness in a patent trial<ref>{{cite web|title=Illumina vs Premaitha|url=http://eplaw.org/wp-content/uploads/2017/12/UK-Illumina-v-Premaitha.docx}}</ref>
== Awards ==
In 2012 he was awarded a Philip Leverhulme Prize<ref>{{cite web|url=https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2012%20prize%20winners%20+%20citations.pdf|title=Leverhulme website|access-date=2018-04-01|archive-url=https://web.archive.org/web/20180402225750/https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2012%20prize%20winners%20+%20citations.pdf|archive-date=2018-04-02}}</ref> for "leading the way by constructing powerful and ingenious novel statistical methodology for population and medical genetics, together with associated fast computational algorithms and software."
== References == {{Reflist}}
== External links == * {{official|https://jmarchini.org/}}
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{{DEFAULTSORT:Marchini, Jonathan}} Category:1977 births Category:Living people Category:Alumni of the University of Oxford Category:Fellows of Somerville College, Oxford Category:British statisticians Category:Alumni of the University of Exeter Category:Biostatisticians Category:21st-century statisticians