{{short description|American scientist}} {{Infobox scientist | name = Jason Locasale | image = | image_size = 154px | caption = Jason Locasale | birth_place = New Jersey, U.S. | death_date = | death_place = | residence = | alma_mater = Rutgers University <small>(B.A.)</small><br />Massachusetts Institute of Technology <small>(Ph.D.)</small><br />Harvard University <small>(Postdoctoral Fellowship)</small> | doctoral_advisor = | doctoral_students = | known_for = | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | signature = | footnotes = | fields = Cancer Research, Metabolism, Metabolomics, Nutrition | work_institutions = Duke University | party = | academic_advisors = Lewis C. Cantley | prizes = }} '''Jason W. Locasale''' is an American scientist and university professor. His focus is on metabolism.
== Education == Locasale graduated summa cum laude from Rutgers University with a dual degree in Chemistry and Physics. While completing his undergraduate degree, he received initial training in research in biochemistry and structural biology under Helen Berman. He earned a Ph.D. from the Massachusetts Institute of Technology. He went on to complete a postdoctoral fellowship at Harvard Medical School under Lewis C. Cantley.<ref>{{Cite web|url=https://www.dukechronicle.com/article/2019/09/duke-university-jason-locasale-fighting-cancer-chemical|title=Jason Locasale: Fighting cancer with chemical complexity and collaboration|website=The Chronicle|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://www.cell-symposia.com/metabolites-2018/bio-locasale.asp|title=Speaker: Cell Symposia: Metabolites as Signalling Molecules|website=www.cell-symposia.com|access-date=2019-12-01}}</ref>
He was an associate professor with tenure until 2024 at Duke University School of Medicine.<ref>{{Cite web|url=https://medschool.duke.edu/about-us/our-faculty/jason-locasale|title=Jason Locasale {{!}} Duke School of Medicine|website=medschool.duke.edu|access-date=2019-12-01|archive-date=2019-09-27|archive-url=https://web.archive.org/web/20190927141925/https://medschool.duke.edu/about-us/our-faculty/jason-locasale|url-status=dead}}</ref>
== Research == Locasale has pioneered the use of methods to study metabolism using primarily liquid chromatography-mass spectrometry (LC-MS),<ref>{{Cite journal|last1=Liu|first1=Xiaojing|last2=Ser|first2=Zheng|last3=Locasale|first3=Jason W|date=2014-02-18|title=Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology|journal=Analytical Chemistry|volume=86|issue=4|pages=2175–2184|doi=10.1021/ac403845u|issn=0003-2700|pmc=3983012|pmid=24410464}}</ref> in particular having developed methods to gain insights into numerous biological processes at once.<ref>{{Cite web|url=https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2016/cancer-metabolism-locasale|title=Cancer Metabolism: A Conversation with Jason Locasale|date=2016-11-28|website=National Cancer Institute|access-date=2019-12-01}}</ref> He has made contributions to understanding the role of serine synthesis and one carbon metabolism in cancers,<ref>{{Cite journal|last=Locasale|first=Jason W.|date=August 2013|title=Serine, glycine and one-carbon units: cancer metabolism in full circle|journal=Nature Reviews Cancer|volume=13|issue=8|pages=572–583|doi=10.1038/nrc3557|issn=1474-1768|pmc=3806315|pmid=23822983}}</ref><ref>{{Cite journal|last1=Gao|first1=Xia|last2=Lee|first2=Katie|last3=Reid|first3=Michael A.|last4=Sanderson|first4=Sydney M.|last5=Qiu|first5=Chuping|last6=Li|first6=Siqi|last7=Liu|first7=Juan|last8=Locasale|first8=Jason W.|date=2018-03-27|title=Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism|url= |journal=Cell Reports|volume=22|issue=13|pages=3507–3520|doi=10.1016/j.celrep.2018.03.017|issn=2211-1247|pmc=6054483|pmid=29590619}}</ref><ref>{{Cite journal|last1=Locasale|first1=Jason W.|last2=Grassian|first2=Alexandra R.|last3=Melman|first3=Tamar|last4=Lyssiotis|first4=Costas A.|last5=Mattaini|first5=Katherine R.|last6=Bass|first6=Adam J.|last7=Heffron|first7=Gregory|last8=Metallo|first8=Christian M.|last9=Muranen|first9=Taru|last10=Sharfi|first10=Hadar|last11=Sasaki|first11=Atsuo T.|date=September 2011|title=Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis|journal=Nature Genetics|language=en|volume=43|issue=9|pages=869–874|doi=10.1038/ng.890|pmid=21804546|issn=1546-1718|pmc=3677549}}</ref><ref>{{Cite journal|last1=Reid|first1=Michael A.|last2=Allen|first2=Annamarie E.|last3=Liu|first3=Shiyu|last4=Liberti|first4=Maria V.|last5=Liu|first5=Pei|last6=Liu|first6=Xiaojing|last7=Dai|first7=Ziwei|last8=Gao|first8=Xia|last9=Wang|first9=Qian|last10=Liu|first10=Ying|last11=Lai|first11=Luhua|date=2018-12-21|title=Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism|journal=Nature Communications|language=en|volume=9|issue=1|pages=5442|doi=10.1038/s41467-018-07868-6|pmid=30575741|pmc=6303315|issn=2041-1723|bibcode=2018NatCo...9.5442R|doi-access=free}}</ref><ref>{{Cite journal|last1=Mehrmohamadi|first1=Mahya|last2=Liu|first2=Xiaojing|last3=Shestov|first3=Alexander A.|last4=Locasale|first4=Jason W.|date=2014-11-20|title=Characterization of the Usage of the Serine Metabolic Network in Human Cancer|url= |journal=Cell Reports|language=en|volume=9|issue=4|pages=1507–1519|doi=10.1016/j.celrep.2014.10.026|issn=2211-1247|pmid=25456139|pmc=4317399}}</ref> defining the quantitative, mechanistic principles of the Warburg Effect<ref>{{Cite journal|last1=Liberti|first1=Maria V.|last2=Locasale|first2=Jason W.|date=March 2016|title=The Warburg Effect: How Does it Benefit Cancer Cells?|journal=Trends in Biochemical Sciences|volume=41|issue=3|pages=211–218|doi=10.1016/j.tibs.2015.12.001|issn=0968-0004|pmc=4783224|pmid=26778478}}</ref> and altered glucose metabolism in cancer,<ref>{{Cite journal|last1=Liberti|first1=Maria V.|last2=Dai|first2=Ziwei|last3=Wardell|first3=Suzanne E.|last4=Baccile|first4=Joshua A.|last5=Liu|first5=Xiaojing|last6=Gao|first6=Xia|last7=Baldi|first7=Robert|last8=Mehrmohamadi|first8=Mahya|last9=Johnson|first9=Marc O.|last10=Madhukar|first10=Neel S.|last11=Shestov|first11=Alexander A.|date=2017-10-03|title=A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product|journal=Cell Metabolism|volume=26|issue=4|pages=648–659.e8|doi=10.1016/j.cmet.2017.08.017|issn=1932-7420|pmc=5629112|pmid=28918937}}</ref> and the role of metabolism in mediating chromatin status and epigenetics.<ref>{{Cite journal|last1=Mentch|first1=Samantha J.|last2=Mehrmohamadi|first2=Mahya|last3=Huang|first3=Lei|last4=Liu|first4=Xiaojing|last5=Gupta|first5=Diwakar|last6=Mattocks|first6=Dwight|last7=Gómez Padilla|first7=Paola|last8=Ables|first8=Gene|last9=Bamman|first9=Marcas M.|last10=Thalacker-Mercer|first10=Anna E.|last11=Nichenametla|first11=Sailendra N.|date=2015-11-03|title=Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism|url= |journal=Cell Metabolism|volume=22|issue=5|pages=861–873|doi=10.1016/j.cmet.2015.08.024|issn=1550-4131|pmc=4635069|pmid=26411344}}</ref><ref>{{Cite web|url=https://www.the-scientist.com/lab-tools/high-throughput-epigenetics-analyses-30163|title=High-Throughput Epigenetics Analyses|website=The Scientist Magazine®|language=en|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://www.sciencedaily.com/releases/2017/01/170116121823.htm|title=Potentially reversible changes in gene control 'prime' pancreatic cancer cells to spread: Epigenetic changes, not DNA mutations, drive some metastasis|website=ScienceDaily|language=en|access-date=2019-12-25}}</ref> His recent work which has gained widespread public attention<ref>{{Cite web|url=https://www.medicalnewstoday.com/articles/325939.php|title=How a dietary change might boost cancer therapy|website=Medical News Today|date=4 August 2019 |language=en|access-date=2019-12-25}}</ref><ref>{{Cite web|url=https://www.myhighplains.com/news/for-your-health/vegan-diets-may-help-boost-cancer-treatments/|title=Vegan diets may help boost cancer treatments|date=2019-08-06|website=KAMR - MyHighPlains.com|language=en-US|access-date=2019-12-25}}</ref><ref>{{Cite web|url=https://www.thelondoneconomic.com/lifestyle/health/going-vegan-really-can-prevent-cancer/31/07/|title=Going vegan 'really can prevent cancer'|last=Says|first=Dyljohbar|date=2019-07-31|website=The London Economic|language=en-GB|access-date=2019-12-28|archive-date=2019-12-28|archive-url=https://web.archive.org/web/20191228230233/https://www.thelondoneconomic.com/lifestyle/health/going-vegan-really-can-prevent-cancer/31/07/|url-status=dead}}</ref><ref>{{Cite web|url=https://medium.com/@Kahn642/a-low-methionine-diet-new-data-for-cancer-therapy-favors-plant-foods-35aa2af536ce|title=A Low Methionine Diet: New Data for Cancer Therapy Favors Plant Foods|last=Kahn|first=Joel|date=2019-08-05|website=Medium|language=en|access-date=2019-12-28}}</ref> has focused on the effects on dietary methionine restriction and diet in general as a therapeutic approach<ref>{{Cite web|url=https://www.theatlantic.com/health/archive/2019/05/food-cancer/589714/|title=You Can't 'Starve' Cancer, but You Might Help Treat It With Food|last=Hamblin|first=James|date=2019-05-20|website=The Atlantic|language=en-US|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://www.cancer.gov/news-events/cancer-currents-blog/2019/targeting-cancer-metabolism-low-methionine-diet|title=Altering Diet to Enhance Cancer Treatment Response|date=2019-09-03|website=National Cancer Institute|language=en|access-date=2019-12-13}}</ref> to extend lifespan and shape tumor response to therapy.<ref>{{Cite web|url=https://elemental.medium.com/feeding-the-beast-could-eating-the-right-diet-starve-cancers-like-mine-7d621ecf7cfb|title=Feeding the Beast: Could Eating the Right Diet Starve Cancers Like Mine?|last=Stern|first=Adam Philip|date=2019-06-17|website=Medium|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://news.yahoo.com/diet-help-cancer-treatment-study-mice-offers-clues-180127830.html|title=Can diet help cancer treatment? Study in mice offers clues|website=news.yahoo.com|language=en-US|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://cen.acs.org/biological-chemistry/cancer/Mice-fed-low-methionine-diet/97/web/2019/08|title=Mice fed a low-methionine diet respond better to cancer treatments|website=Chemical & Engineering News|language=en|access-date=2019-12-08}}</ref>
His research approaches integrate computational modeling, cell biology, mouse models, and genetic and biochemical experimentation to understand metabolic processes and their contribution to health.<ref>{{Cite web|url=http://www.jlocasale.duke.edu/|title=HOME|website=Locasale Lab|access-date=2019-12-01}}</ref>{{Primary source inline|date=January 2020|reason=Article should not cite the lab website, which the subject of the article is capable of editing. A proper non-primary source is needed here.}} Currently, his research is in three interconnected areas: (1) Quantitative biology of metabolism, (2) Dietary interventions and metabolic therapeutics in health and cancer, and (3) The mechanistic basis between the interaction of metabolism and epigenetics.<ref name=":0">{{Cite journal|date=1970-01-01|title=Editorial Board|url=https://www.cell-stress.com/about-us/editorial-board/|journal=Cell Stress|language=en|issn=2523-0204}}</ref>
== Awards and recognitions == Locasale is a recipient of the National Institutes of Health Pathway to Independence Award, the Benjamin Trump Award for Excellence in Cancer Research, and the American Cancer Society Research Scholar Award, and the JH Quastell Lectureship at McGill University.<ref>{{Cite web|url=https://www.science.org/content/webinar/deciphering-cancer-intersection-epigenetics-metabolism-and-tumorigenesis|title=Deciphering cancer: The intersection of epigenetics, metabolism, and tumorigenesis|date=2017-02-21|website=Science {{!}} AAAS|access-date=2019-12-01}}</ref> He serves on the editorial boards for a number of journals including PLoS Biology, Oncotarget, and Cell Stress,<ref>{{Cite web|url=https://journals.plos.org/plosbiology/s/editorial-board|title=PLOS Biology: A Peer-Reviewed Open-Access Journal|website=journals.plos.org|access-date=2019-12-01}}</ref><ref>{{Cite web|url=http://www.oncotarget.com/index.php?journal=oncotarget&page=pages&op=view&path%5B%5D=board|title=Oncotarget {{!}} Editorial Board/Editors|website=www.oncotarget.com|access-date=2020-01-03}}</ref><ref name=":0" /> and has served in advisory roles for a number of companies. He has also maintained advisory roles at a number of federal, private and international scientific agencies including the National Institutes of Health, the American Cancer Society, and the Israel Science Foundation.{{Citation needed|date=January 2020}} He is also widely accomplished in academic mentoring with students and trainees having received the nation's highest honors at the undergraduate, doctoral, and postdoctorals levels<ref>{{Cite web|url=https://www.cancer.gov/grants-training/training/funding/f99|title=NCI F99/K00 Award|date=2015-12-29|website=National Cancer Institute|language=en|access-date=2019-12-18}}</ref><ref>{{Cite web|url=https://today.duke.edu/2019/05/student-honors-and-laurels-2019|title=Student Honors and Laurels for 2019|website=today.duke.edu|language=en|access-date=2019-12-18}}</ref>{{Failed verification|date=January 2020}}.
Locasale has authored over 150 publications in peer-reviewed journals and numerous textbook chapters and patents. In 2019, he was named one of the most influential researchers of the past 10 years by Web of Science.<ref>{{Cite web|url=https://medschool.duke.edu/about-us/news-and-communications/med-school-blog/school-medicine-faculty-recognized-%E2%80%98highly-cited%E2%80%99-list|title=School of Medicine Faculty Recognized on 'Highly Cited' List {{!}} Duke School of Medicine|website=medschool.duke.edu|access-date=2019-12-01|archive-date=2020-04-07|archive-url=https://web.archive.org/web/20200407101314/https://medschool.duke.edu/about-us/news-and-communications/med-school-blog/school-medicine-faculty-recognized-%E2%80%98highly-cited%E2%80%99-list|url-status=dead}}</ref><ref>{{Cite web|url=https://publons.com/awards/highly-cited/2019/|title=Highly Cited Researchers|website=publons.com|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://today.duke.edu/2019/11/global-list-highly-cited-puts-duke-top-ten|title=Global List of Highly Cited Puts Duke in Top Ten|website=today.duke.edu|language=en|access-date=2019-12-25}}</ref>
== References ==<!-- Inline citations added to your article will automatically display here. See en.wikipedia.org/wiki/WP:REFB for instructions on how to add citations. --> {{reflist}}
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{{DEFAULTSORT:Locasale, Jason}} Category:1981 births Category:American cancer researchers Category:Duke University School of Medicine faculty Category:Massachusetts Institute of Technology alumni Category:Living people Category:Rutgers University alumni Category:21st-century American scientists