Interolog

An '''interolog''' is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.<ref>{{Cite journal | last1 = Walhout | first1 = A. J. | last2 = Sordella | first2 = R. | last3 = Lu | first3 = X. | last4 = Hartley | first4 = J. L. | last5 = Temple | first5 = G. F. | last6 = Brasch | first6 = M. A. | last7 = Thierry-Mieg | first7 = N. | last8 = Vidal | first8 = M. | doi = 10.1126/science.287.5450.116 | title = Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development | journal = Science | volume = 287 | issue = 5450 | pages = 116–122 | year = 2000 | pmid = 10615043| bibcode = 2000Sci...287..116W }}</ref><ref>{{Cite journal | doi=10.1101/gr.1774904| pmid=15173116| pmc=419789| title=Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs| journal=Genome Research| volume=14| issue=6| pages=1107–1118| year=2004| last1=Yu| first1=H.| last2=Luscombe| first2=N. M.| last3=Lu| first3=H. X.| last4=Zhu| first4=X.| last5=Xia| first5=Y.| last6=Han| first6=J. D.| last7=Bertin| first7=N.| last8=Chung| first8=S.| last9=Vidal| first9=M.| last10=Gerstein| first10=M.}}</ref>

== Example ==

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Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold: *A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence). *B is a homolog of B'. *A and B interact. *A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

==References== {{reflist}} {{refbegin}} * {{Cite journal | last1 = Yu | first1 = H. | last2 = Luscombe | first2 = N. M. | last3 = Lu | first3 = H. X. | last4 = Zhu | first4 = X. | last5 = Xia | first5 = Y. | last6 = Han | first6 = J. D. | last7 = Bertin | first7 = N. | last8 = Chung | first8 = S. | last9 = Vidal | first9 = M. | last10 = Gerstein | first10 = M. | title = Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs | doi = 10.1101/gr.1774904 | journal = Genome Research | volume = 14 | issue = 6 | pages = 1107–1118 | year = 2004 | pmid = 15173116 | pmc =419789 }} * {{Cite journal | last1 = Kemmer | first1 = D. | last2 = Huang | first2 = Y. | last3 = Shah | first3 = S. P. | last4 = Lim | first4 = J. | last5 = Brumm | first5 = J. | last6 = Yuen | first6 = M. M. | last7 = Ling | first7 = J. | last8 = Xu | first8 = T. | last9 = Wasserman | first9 = W. W. | last10 = Ouellette | first10 = B. F. | title = Ulysses - an application for the projection of molecular interactions across species | journal = Genome Biology | volume = 6 | issue = 12 | pages = R106 | doi = 10.1186/gb-2005-6-12-r106 | year = 2005 | pmid = 16356269 | pmc =1414088 | doi-access = free }} * {{Cite journal | last1 = Wiles | first1 = A. M. | last2 = Doderer | first2 = M. | last3 = Ruan | first3 = J. | last4 = Gu | first4 = T. T. | last5 = Ravi | first5 = D. | last6 = Blackman | first6 = B. | last7 = Bishop | first7 = A. J. | title = Building and analyzing protein interactome networks by cross-species comparisons | doi = 10.1186/1752-0509-4-36 | journal = BMC Systems Biology | volume = 4 | pages = 36 | year = 2010 | pmid = 20353594 | pmc =2859380 | doi-access = free }} {{refend}}

==External links== * [http://interactome.org Interactome.org] {{Webarchive|url=https://web.archive.org/web/20080820063335/http://interactome.org/ |date=2008-08-20 }}: Interactome portal site. * {{usurped|1=[https://web.archive.org/web/20080706140930/http://interactomics.org/ Interactomics.org]}}: Interactomics portal site. * [http://www.interologfinder.org]: Cross-species interaction prediction site.

Category:Protein complexes Category:Bioinformatics