Integrin beta 5

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Integrin beta-5''' is a protein that in humans is encoded by the ''ITGB5'' gene.<ref name="pmid2211615">{{cite journal |vauthors=McLean JW, Vestal DJ, Cheresh DA, Bodary SC | title = cDNA sequence of the human integrin beta 5 subunit | journal = J Biol Chem | volume = 265 | issue = 28 | pages = 17126–31 |date=Nov 1990 | doi = 10.1016/S0021-9258(17)44878-2 | pmid = 2211615 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITGB5 integrin, beta 5| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3693}}</ref>

==Interactions== Integrin, beta 5 has been shown to interact with PTK2,<ref name=pmid11927607>{{cite journal |last=Eliceiri |first=Brian P |author2=Puente Xose S |author3=Hood John D |author4=Stupack Dwayne G |author5=Schlaepfer David D |author6=Huang Xiaozhu Z |author7=Sheppard Dean |author8=Cheresh David A |date=Apr 2002 |title=Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling |journal=J. Cell Biol. |volume=157 |issue=1 |pages=149–60 | issn = 0021-9525| pmid = 11927607 |doi = 10.1083/jcb.200109079 |pmc=2173263 }}</ref> Annexin A5<ref name=pmid12769841>{{cite journal |last=Cardó-Vila |first=Marina |author2=Arap Wadih |author3=Pasqualini Renata |date=May 2003 |title=Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V |journal=Mol. Cell |volume=11 |issue=5 |pages=1151–62 | issn = 1097-2765| pmid = 12769841 |doi=10.1016/S1097-2765(03)00138-2 |doi-access=free }}</ref> and PAK4.<ref name=pmid12356872>{{cite journal |last=Zhang |first=Hongquan |author2=Li Zhilun |author3=Viklund Eva-Karin |author4=Strömblad Staffan |date=Sep 2002 |title=P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration |journal=J. Cell Biol. |volume=158 |issue=7 |pages=1287–97 | issn = 0021-9525| pmid = 12356872 |doi=10.1083/jcb.200207008 |pmc=2173231 }}</ref>

== Functions == ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.<ref>{{Cite journal |last1=Zhang |first1=Lu-yang |last2=Guo |first2=Qing |last3=Guan |first3=Ge-fei |last4=Cheng |first4=Wen |last5=Cheng |first5=Peng |last6=Wu |first6=An-hua |date=2019 |title=Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma |journal=Frontiers in Oncology |volume=9 |page=904 |doi=10.3389/fonc.2019.00904 |pmid=31616629 |pmc=6764112 |issn=2234-943X|doi-access=free }}</ref>

== Clinical significance ==

===Research=== Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.<ref name=" pmid = 24336069">{{cite journal | author = Coudert, AE | title = Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology. | journal = Lab. Invest. | volume = 94 | issue = 3 |date=Mar 2014 | pmid = 24336069 | pages = 275–285 | doi=10.1038/labinvest.2013.140| s2cid = 5097233 | url = https://hal.archives-ouvertes.fr/hal-01511438/file/labinvest2013AEC.pdf | doi-access = free }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | author=Evans JP |title=Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. |journal=BioEssays |volume=23 |issue= 7 |pages= 628–39 |year= 2001 |pmid= 11462216 |doi= 10.1002/bies.1088 |s2cid=23712246 }} *{{cite journal |vauthors=Smith JW, Vestal DJ, Irwin SV, etal |title=Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. |journal=J. Biol. Chem. |volume=265 |issue= 19 |pages= 11008–13 |year= 1990 |doi=10.1016/S0021-9258(19)38549-7 |pmid= 1694173 |doi-access=free }} *{{cite journal |vauthors=Adams JC, Watt FM |title=Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. |journal=J. Cell Biol. |volume=115 |issue= 3 |pages= 829–41 |year= 1991 |pmid= 1918165 |doi=10.1083/jcb.115.3.829 | pmc=2289188 }} *{{cite journal |vauthors=Ramaswamy H, Hemler ME |title=Cloning, primary structure and properties of a novel human integrin beta subunit. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1561–8 |year= 1990 |pmid= 2328726 |doi= 10.1002/j.1460-2075.1990.tb08275.x| pmc=551850 }} *{{cite journal |vauthors=Suzuki S, Huang ZS, Tanihara H |title=Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 14 |pages= 5354–8 |year= 1990 |pmid= 2371275 |doi=10.1073/pnas.87.14.5354 | pmc=54322 |bibcode=1990PNAS...87.5354S |doi-access=free }} *{{cite journal |vauthors=Hu DD, Lin EC, Kovach NL, etal |title=A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26232–8 |year= 1995 |pmid= 7592829 |doi=10.1074/jbc.270.44.26232 |doi-access=free }} *{{cite journal |vauthors=Vogel BE, Lee SJ, Hildebrand A, etal |title=A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin. |journal=J. Cell Biol. |volume=121 |issue= 2 |pages= 461–8 |year= 1993 |pmid= 7682219 |doi=10.1083/jcb.121.2.461 | pmc=2200091 }} *{{cite journal |vauthors=Pasqualini R, Bodorova J, Ye S, Hemler ME |title=A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. |journal=J. Cell Sci. |volume=105 |issue= 1|pages= 101–11 |year= 1993 |doi=10.1242/jcs.105.1.101 |pmid= 7689573 }} *{{cite journal |vauthors=Lafrenie RM, Wahl LM, Epstein JS, etal |title=HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. |journal=Journal of Immunology |volume=157 |issue= 3 |pages= 974–7 |year= 1996 |doi=10.4049/jimmunol.157.3.974 |pmid= 8757599 |doi-access=free }} *{{cite journal |vauthors=Rabb H, Barroso-Vicens E, Adams R, etal |title=Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney. |journal=Am. J. Nephrol. |volume=16 |issue= 5 |pages= 402–8 |year= 1997 |pmid= 8886177 |doi=10.1159/000169032 }} *{{cite journal |vauthors=Liliental J, Chang DD |title=Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2379–83 |year= 1998 |pmid= 9442085 |doi=10.1074/jbc.273.4.2379 |doi-access=free }} *{{cite journal |vauthors=Memmo LM, McKeown-Longo P |title=The alphavbeta5 integrin functions as an endocytic receptor for vitronectin. |journal=J. Cell Sci. |volume=111 |issue= 4|pages= 425–33 |year= 1998 |doi=10.1242/jcs.111.4.425 |pmid= 9443892 }} *{{cite journal |vauthors=Zhang H, Tan SM, Lu J |title=cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing. |journal=Biochem. J. |volume=331 |issue= 2|pages= 631–7 |year= 1998 |pmid= 9531507 |doi= 10.1042/bj3310631| pmc=1219398 }} *{{cite journal |vauthors=Barillari G, Sgadari C, Palladino C, etal |title=Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. |journal=Journal of Immunology |volume=163 |issue= 4 |pages= 1929–35 |year= 1999 |doi=10.4049/jimmunol.163.4.1929 |pmid= 10438928 |doi-access=free }} *{{cite journal |vauthors=Carriero MV, Del Vecchio S, Capozzoli M, etal |title=Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5307–14 |year= 1999 |pmid= 10537314 }} *{{cite journal |vauthors=Tang S, Gao Y, Ware JA |title=Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein. |journal=J. Cell Biol. |volume=147 |issue= 5 |pages= 1073–84 |year= 1999 |pmid= 10579726 |doi=10.1083/jcb.147.5.1073 | pmc=2169340 }} *{{cite journal |vauthors=Cirulli V, Beattie GM, Klier G, etal |title=Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. |journal=J. Cell Biol. |volume=150 |issue= 6 |pages= 1445–60 |year= 2000 |pmid= 10995448 |doi=10.1083/jcb.150.6.1445 | pmc=2150716 }} *{{cite journal |vauthors=Albert ML, Kim JI, Birge RB |title=alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 899–905 |year= 2001 |pmid= 11146654 |doi= 10.1038/35046549 |s2cid=7535200 }} *{{cite journal |vauthors=Zhou M, Graham R, Russell G, Croucher PI |title=MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 574–80 |year= 2001 |pmid= 11162558 |doi= 10.1006/bbrc.2000.4155 }} *{{cite journal |vauthors=Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN |title=The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. |journal=Eur J Cancer Prev |volume=16 |issue= 6 |pages= 517–27 |year= 2007 |pmid= 18090124 | doi=10.1097/CEJ.0b013e3280145c00 |s2cid=1825380 }} {{refend}}

==External links== *[https://web.archive.org/web/20110722014307/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001711 ITGB5] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] {{Webarchive|url=https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml |date=2014-12-11 }}

{{Integrins}}

Category:Integrins

{{Transmembranereceptor-stub}}