{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2''' is an enzyme that in humans is encoded by the ''INPPL1'' gene.<ref name="pmid8530088">{{cite journal | vauthors = Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE | title = Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases | journal = Genomics | volume = 29 | issue = 1 | pages = 285–7 | date = February 1996 | pmid = 8530088 | doi = 10.1006/geno.1995.1247 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3636}}</ref>
INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.<ref name="entrez"/>
== Interactions ==
INPPL1 has been shown to interact with: * BCAR1,<ref name = pmid11158326>{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1416–28 | date = February 2001 | pmid = 11158326 | pmc = 99593 | doi = 10.1128/MCB.21.4.1416-1428.2001 }}</ref> * FLNC,<ref name = pmid11739414>{{cite journal | vauthors = Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA | title = The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin | journal = J. Cell Biol. | volume = 155 | issue = 6 | pages = 1065–79 | date = December 2001 | pmid = 11739414 | pmc = 2150887 | doi = 10.1083/jcb.200104005 }}</ref> * SHC1,<ref name = pmid10194451>{{cite journal | vauthors = Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B | title = A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells | journal = Blood | volume = 93 | issue = 8 | pages = 2707–20 | date = April 1999 | pmid = 10194451 | doi = 10.1182/blood.V93.8.2707}}</ref><ref name = pmid11349134>{{cite journal | vauthors = Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C | title = The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28348–55 | date = July 2001 | pmid = 11349134 | doi = 10.1074/jbc.M103537200 | doi-access = free }}</ref><ref name = pmid9660833>{{cite journal | vauthors = Habib T, Hejna JA, Moses RE, Decker SJ | title = Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18605–9 | date = July 1998 | pmid = 9660833 | doi = 10.1074/jbc.273.29.18605| doi-access = free }}</ref> and * SORBS1.<ref name = pmid12504111>{{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2 | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 2 | pages = 494–500 | date = January 2003 | pmid = 12504111 | doi = 10.1016/s0006-291x(02)02894-2| bibcode = 2003BBRC..300..494V }}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} *{{cite journal | vauthors = Pesesse X, Deleu S, De Smedt F, Drayer L, Erneux C | title = Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 3 | pages = 697–700 | year = 1997 | pmid = 9367831 | doi = 10.1006/bbrc.1997.7538 | bibcode = 1997BBRC..239..697P }} *{{cite journal | vauthors = Habib T, Hejna JA, Moses RE, Decker SJ | title = Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein. | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18605–9 | year = 1998 | pmid = 9660833 | doi = 10.1074/jbc.273.29.18605 | doi-access = free }} *{{cite journal | vauthors = Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C | title = The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. | journal = FEBS Lett. | volume = 437 | issue = 3 | pages = 301–3 | year = 1998 | pmid = 9824312 | doi = 10.1016/S0014-5793(98)01255-1 | s2cid = 22837416 | doi-access = free | bibcode = 1998FEBSL.437..301P }} *{{cite journal | vauthors = Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B | title = A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. | journal = Blood | volume = 93 | issue = 8 | pages = 2707–20 | year = 1999 | pmid = 10194451 | doi = 10.1182/blood.V93.8.2707}} *{{cite journal | vauthors = Bruyns C, Pesesse X, Moreau C, Blero D, Erneux C | title = The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes. | journal = Biol. Chem. | volume = 380 | issue = 7–8 | pages = 969–74 | year = 1999 | pmid = 10494849 | doi = 10.1515/BC.1999.120 | s2cid = 42081112 }} *{{cite journal | vauthors = Schurmans S, Carrió R, Behrends J, Pouillon V, Merino J, Clément S | title = The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. | journal = Genomics | volume = 62 | issue = 2 | pages = 260–71 | year = 2000 | pmid = 10610720 | doi = 10.1006/geno.1999.5995 }} *{{cite journal | vauthors = Muraille E, Bruhns P, Pesesse X, Daëron M, Erneux C | title = The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. | journal = Immunol. Lett. | volume = 72 | issue = 1 | pages = 7–15 | year = 2000 | pmid = 10789675 | doi = 10.1016/S0165-2478(00)00162-0 }} *{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1416–28 | year = 2001 | pmid = 11158326 | pmc = 99593 | doi = 10.1128/MCB.21.4.1416-1428.2001 }} *{{cite journal | vauthors = Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M | title = Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. | journal = Mol. Cell. Biol. | volume = 21 | issue = 5 | pages = 1633–46 | year = 2001 | pmid = 11238900 | pmc = 86709 | doi = 10.1128/MCB.21.5.1633-1646.2001 }} *{{cite journal | vauthors = Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C | title = The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28348–55 | year = 2001 | pmid = 11349134 | doi = 10.1074/jbc.M103537200 | doi-access = free }} *{{cite journal | vauthors = Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA | title = The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. | journal = J. Cell Biol. | volume = 155 | issue = 6 | pages = 1065–79 | year = 2002 | pmid = 11739414 | pmc = 2150887 | doi = 10.1083/jcb.200104005 }} *{{cite journal | vauthors = Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S | title = The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. | journal = Diabetes | volume = 51 | issue = 7 | pages = 2012–7 | year = 2002 | pmid = 12086927 | doi = 10.2337/diabetes.51.7.2012 | doi-access = free | hdl = 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/17879 | hdl-access = free }} *{{cite journal | vauthors = Giuriato S, Blero D, Robaye B, Bruyns C, Payrastre B, Erneux C | title = SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line. | journal = Biochem. Biophys. Res. Commun. | volume = 296 | issue = 1 | pages = 106–10 | year = 2002 | pmid = 12147234 | doi = 10.1016/S0006-291X(02)00787-8 | bibcode = 2002BBRC..296..106G }} *{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. | journal = J. Cell Sci. | volume = 115 | issue = Pt 19 | pages = 3807–15 | year = 2003 | pmid = 12235291 | doi = 10.1242/jcs.00070 | doi-access = free }} *{{cite journal | vauthors = Tridandapani S, Wang Y, Marsh CB, Anderson CL | title = Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. | journal = J. Immunol. | volume = 169 | issue = 8 | pages = 4370–8 | year = 2002 | pmid = 12370370 | doi = 10.4049/jimmunol.169.8.4370 | doi-access = free }} *{{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 2 | pages = 494–500 | year = 2003 | pmid = 12504111 | doi = 10.1016/S0006-291X(02)02894-2 | bibcode = 2003BBRC..300..494V }} *{{cite journal | vauthors = Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC | title = Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 2 | pages = 443–8 | year = 2003 | pmid = 12522270 | pmc = 141014 | doi = 10.1073/pnas.2436191100 | bibcode = 2003PNAS..100..443S | doi-access = free }} *{{cite journal | vauthors = Pengal RA, Ganesan LP, Fang H, Marsh CB, Anderson CL, Tridandapani S | title = SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22657–63 | year = 2003 | pmid = 12690104 | doi = 10.1074/jbc.M302907200 | doi-access = free }} *{{cite journal | vauthors = Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D | title = Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. | journal = Diabetes | volume = 53 | issue = 7 | pages = 1900–4 | year = 2004 | pmid = 15220217 | doi = 10.2337/diabetes.53.7.1900 | doi-access = free | hdl = 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/55046 | hdl-access = free }} *{{cite journal | vauthors = Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, Willoughby CE | title = Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract | journal = The American Journal of Human Genetics | volume = 89 | issue = 5 | pages = 628–33 | year = 2011 | pmid = 21996275 | pmc = 3213395 | doi = 10.1016/j.ajhg.2011.09.014 }} {{refend}}
Category:EC 3.1.3