INPP5B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Type II inositol-1,4,5-trisphosphate 5-phosphatase''' is an enzyme that in humans is encoded by the ''INPP5B'' gene.<ref name="pmid1718960">{{cite journal |vauthors=Ross TS, Jefferson AB, Mitchell CA, Majerus PW | title = Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase | journal = J Biol Chem | volume = 266 | issue = 30 | pages = 20283–9 |date=Dec 1991 | doi = 10.1016/S0021-9258(18)54920-6 | pmid = 1718960 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3633}}</ref>

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3633}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Mitchell CA, Connolly TM, Majerus PW |title=Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. |journal=J. Biol. Chem. |volume=264 |issue= 15 |pages= 8873–7 |year= 1989 |doi=10.1016/S0021-9258(18)81874-9 |pmid= 2542294 |doi-access=free }} *{{cite journal |vauthors=Jefferson AB, Majerus PW |title=Properties of type II inositol polyphosphate 5-phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9370–7 |year= 1995 |pmid= 7721860 |doi=10.1074/jbc.270.16.9370 |doi-access=free }} *{{cite journal |vauthors=Jänne PA, Dutra AS, Dracopoli NC, etal |title=Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 3 |pages= 164–6 |year= 1994 |pmid= 8125013 |doi=10.1159/000133691 |url=https://zenodo.org/record/1235405 }} *{{cite journal |vauthors=Speed CJ, Matzaris M, Bird PI, Mitchell CA |title=Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. |journal=Eur. J. Biochem. |volume=234 |issue= 1 |pages= 216–24 |year= 1996 |pmid= 8529643 |doi=10.1111/j.1432-1033.1995.216_c.x |doi-access=free }} *{{cite journal |vauthors=Jänne PA, Rochelle JM, Martin-DeLeon PA, etal |title=Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens. |journal=Genomics |volume=28 |issue= 2 |pages= 280–5 |year= 1996 |pmid= 8530037 |doi= 10.1006/geno.1995.1142 |url=https://zenodo.org/record/1229663 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B |s2cid=39457788 }} *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }} {{refend}}