{{Short description|InterPro protein family}} {{Redirect|IF-2|other uses|IF2 (disambiguation){{!}}IF2}} {{Pfam box |Name=Translation initiation factor IF-2, bacterial-like |InterPro=IPR000178 }} '''Bacterial initiation factor-2''' is a bacterial initiation factor.<ref>{{MeshName|Prokaryotic+Initiation+Factor-2}}</ref>
IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA<sub>f</sub> binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and P<sub>i</sub>, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.
Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.<ref>{{cite journal | vauthors = D'Souza AR, Minczuk M | title = Mitochondrial transcription and translation: overview | journal = Essays in Biochemistry | volume = 62 | issue = 3 | pages = 309–320 | date = July 2018 | pmid = 30030363 | pmc = 6056719 | doi = 10.1042/EBC20170102 }}</ref>
== References == {{reflist}}
{{GeneticTranslation}} {{GTPases}}
Category:Protein biosynthesis Category:Gene expression