{{Infobox scientist | name = | image = <!--(filename only, i.e. without "File:" prefix)--> | birth_date = March 14, 1891 | birth_place = Iowa | death_date = January 6, 1977 | death_place = | death_cause = | citizenship = | nationality = | fields = | workplaces = {{plainlist| *Western Reserve University *Mount Sinai Hospital }} | education = | alma_mater = {{plainlist| *McGill University * }} | known_for = | awards = | spouse = <!--(or | spouses = )--> | children = 2 }} '''Harry Goldblatt''' (March 14, 1891 – January 6, 1977) was an American pathologist best known for his discovery of the role of kidneys in regulating blood pressure.

== Biography ==

Goldblatt was born March 14, 1891, in Iowa to Phillip and Jennie Spitz Goldblatt.<ref name=case/>

Goldblatt graduated from McGill University with a B.A. in 1912 and an M.D. degree in 1916. He then served at Royal Victoria Hospital, Montreal and as a member of the Medical Reserve Corps of the United States Army, before doing a residency at Lakeside Hospital in Cleveland, Ohio.<ref name=case/> He studied pathology and surgery at the Lister Institute of Preventative Medicine and University College London.<ref name=NAS/>

From 1924 to 1946, he was a professor of pathology at Western Reserve University. He then was the director of the Institute for Medical Research Cedars of Lebanon Hospital in Los Angeles, before returning to Cleveland in 1953 to work at Mount Sinai Hospital.<ref name=case/><ref name=NAS>{{cite web |title=Harry Goldblatt |url=http://www.nasonline.org/member-directory/deceased-members/20001171.html |website=www.nasonline.org |accessdate=12 April 2019}}</ref>

Goldblatt married Jeanne Rea on June 25, 1929,<ref name="case">{{cite web |title=GOLDBLATT, HARRY |url=https://case.edu/ech/articles/g/goldblatt-harry |website=Encyclopedia of Cleveland History {{!}} Case Western Reserve University |accessdate=12 April 2019 |language=en |date=11 May 2018}}</ref> and had two sons, both doctors.<ref name=NYT/>

He retired in 1976 and died of pulmonary edema in 1977.<ref name="NYT">{{cite news |last1=Devlin |first1=John C. |title=Dr, Harry Goldblatt, Blood Researcher |url=https://www.nytimes.com/1977/01/08/archives/dr-harry-goldblatt-blood-researcher-pioneer-produced-experimental.html |accessdate=12 April 2019 |work=The New York Times |date=8 January 1977}}</ref>

== Research == As a pathologist, Goldblatt had observed narrowing of renal blood vessels in autopsies of people with hypertension. He hypothesized that decreased blood flow to the kidneys could have a role in increasing blood pressure. To test this, he partially clamped shut the renal arteries in dogs to decrease the blood flow, and observed a rise in blood pressure in response. He published these findings in 1934. In later years, it was discovered that the lack of blood flow to the kidneys causes a release of renin, triggering vasoconstriction and a corresponding increase in blood pressure.<ref>{{cite journal |last1=Epps |first1=Heather L. Van |title=Harry Goldblatt and the discovery of renin |journal=Journal of Experimental Medicine |date=2 May 2005 |volume=201 |issue=9 |pages=1351 |doi=10.1084/jem.2019fta |url=http://jem.rupress.org/content/201/9/1351.full |accessdate=12 April 2019 |language=en |issn=0022-1007|pmc=2213196 |pmid=15940810 }}</ref>

Because of his contributions, the World Health Organization has designated "Goldblatt units" as the standard unit of measure of renin.<ref name=NAS/>

== Honors == In 1973, Goldblatt was inducted into the National Academy of Sciences. And in 1976, he received the Scientific Achievement Award of the American Medical Association.<ref name=NAS/>

The American Heart Association has established the Harry Goldblatt Award in Cardiovascular Research.<ref>{{cite web |title=Harry Goldblatt Award for New Investigators |url=https://professional.heart.org/professional/MembershipCouncils/AwardsLectures/UCM_437539_Harry-Goldblatt-Award-for-New-Investigators.jsp |website=professional.heart.org |accessdate=12 April 2019}}</ref><ref>{{cite journal |title=Harry Goldblatt Award 2001 |journal=Hypertension |date=1 February 2002 |volume=39 |issue=2 |pages=728–729 |doi=10.1161/hy0202.104349 |url=https://www.ahajournals.org/doi/10.1161/hy0202.104349 |accessdate=12 April 2019|doi-access=free }}</ref>

== References == {{Reflist}}

== External links == * [https://jamanetwork.com/journals/jama/article-abstract/356239 Harry Goldblatt: 1891-1977 (JAMA)]

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Category:Case Western Reserve University faculty Category:American pathologists Category:1891 births Category:1977 deaths