{{Short description|Fibrosarcoma cell line}} thumb | right'''HT1080''' is a fibrosarcoma cell line which has been used extensively in biomedical research. The cell line was created from tissue taken in a biopsy of a fibrosarcoma present in a 35-year-old human male.<ref name=Rasheed1974>{{cite journal |pages=1027–33 |doi=10.1002/1097-0142(197404)33:4<1027::AID-CNCR2820330419>3.0.CO;2-Z |title=Characterization of a newly derived human sarcoma cell line (HT-1080) |year=1974 |last1=Rasheed |first1=Suraiya |last2=Nelson-Rees |first2=Walter A. |last3=Toth |first3=Eva M. |last4=Arnstein |first4=Paul |last5=Gardner |first5=Murray B. |journal=Cancer |volume=33 |issue=4 |pmid=4132053|doi-access=free }}</ref> The patient who supplied the sample had not undergone radio or chemotherapy, making it less likely that unwanted mutations were introduced into the cell line.
The cell line carries an IDH1 mutation and an activated N-ras oncogene.<ref>{{cite journal|title=Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.|pmid=6744274|journal=Cancer Research|date=August 1984|first1=WF|last1=Benedict|display-authors=etal|volume=44|issue=8|pages=3471–3479}}</ref>
==References== {{reflist}}
==External links== *[https://www.cellosaurus.org/CVCL_0317 Cellosaurus entry for HT1080] Category:Cancer cell lines Category:Cancer research Category:Human cell lines Category: fibrosarcoma cell line
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