HSPB6

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Heat shock protein beta-6''' (HSPB6) is a protein that in humans is encoded by the ''HSPB6'' gene.<ref name="pmid12820654">{{cite journal |vauthors=Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW | title = The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10 | journal = Cell Stress & Chaperones | volume = 8 | issue = 1 | pages = 53–61 |date=Jun 2003 | doi = 10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 | doi-broken-date = 12 July 2025 | pmid = 12820654 | pmc = 514853 }}</ref><ref name="pmid14717697">{{cite journal |vauthors=Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB | title = Some properties of human small heat shock protein Hsp20 (HspB6) | journal = Eur J Biochem | volume = 271 | issue = 2 | pages = 291–302 |date=Jan 2004 | pmid = 14717697 | doi =10.1046/j.1432-1033.2003.03928.x | doi-access = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=126393}}</ref>

HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin).<ref name="pmid8195168">{{cite journal |vauthors=Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T | title = Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin | journal = J. Biol. Chem. | volume = 269 | issue = 21 | pages = 15302–9 |date=May 1994 | doi = 10.1016/S0021-9258(17)36606-1 | pmid = 8195168 | doi-access = free }}</ref>

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance<ref name="PMC2866971">{{cite journal |vauthors=Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM | title = The small heat shock protein, HSPB6, in muscle function and disease | journal = Cell Stress & Chaperones | volume = 15 | issue = 1 | pages = 1–11 |date=Jan 2010 | pmid = 19568960| pmc = 2866971 | doi =10.1007/s12192-009-0127-8 }}</ref> and in smooth and cardiac muscle.<ref name="pmid18579210">{{cite journal |vauthors=Salinthone S, Tyagi M, Gerthoffer WT | title = Small heat shock proteins in smooth muscle | journal = Pharmacol. Ther. | volume = 119 | issue = 1 | pages = 44–54 |date=July 2008 | pmid = 18579210 | pmc = 2581864 | doi = 10.1016/j.pharmthera.2008.04.005 }}</ref><ref name="pmid16099377">{{cite journal |vauthors=Fan GC, Chu G, Kranias EG | title = Hsp20 and its cardioprotection | journal = Trends Cardiovasc. Med. | volume = 15 | issue = 4 | pages = 138–41 |date=May 2005 | pmid = 16099377 | doi = 10.1016/j.tcm.2005.05.004 }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Fontaine JM, Sun X, Benndorf R, Welsh MJ |title=Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 3 |pages= 1006–11 |year= 2005 |pmid= 16225851 |doi= 10.1016/j.bbrc.2005.09.148 |bibcode=2005BBRC..337.1006F }} *{{cite journal |vauthors=Flynn CR, Smoke CC, Furnish E, etal |title=Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli. |journal=Protein Expr. Purif. |volume=52 |issue= 1 |pages= 50–8 |year= 2007 |pmid= 17084643 |doi= 10.1016/j.pep.2006.08.015 | pmc=1839877 }} *{{cite journal |vauthors=Chernik IS, Seit-Nebi AS, Marston SB, Gusev NB |title=Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. |journal=Mol. Cell. Biochem. |volume=295 |issue= 1–2 |pages= 9–17 |year= 2007 |pmid= 17109079 |doi= 10.1007/s11010-006-9266-8 |s2cid=6389210 }} {{refend}}

== External links == * {{PDBe-KB2|O14558|Heat shock protein beta-6}}

Category:Heat shock proteins