HSPB2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Heat shock protein beta-2''' is a protein that in humans is encoded by the ''HSPB2'' gene.<ref name="pmid9344664">{{cite journal | vauthors = Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y | title = Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner | journal = Genomics | volume = 45 | issue = 2 | pages = 386–94 | date = February 1998 | pmid = 9344664 | doi = 10.1006/geno.1997.4956 }}</ref><ref name="pmid9490724">{{cite journal | vauthors = Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S | title = MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase | journal = J Cell Biol | volume = 140 | issue = 5 | pages = 1113–24 | date = April 1998 | pmid = 9490724 | pmc = 2132705 | doi = 10.1083/jcb.140.5.1113 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HSPB2 heat shock 27kDa protein 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3316}}</ref>

== Interactions ==

HSPB2 has been shown to interact with: * CRYAB,<ref name = pmid10625651/> * HSPB8,<ref name = pmid14594798>{{cite journal | vauthors = Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R | title = Interaction of human HSP22 (HSPB8) with other small heat shock proteins | journal = J. Biol. Chem. | volume = 279 | issue = 4 | pages = 2394–402 | date = January 2004 | pmid = 14594798 | doi = 10.1074/jbc.M311324200 | doi-access = free }}</ref><ref name = pmid11342557>{{cite journal | vauthors = Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ | title = HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27) | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 26753–61 | date = July 2001 | pmid = 11342557 | doi = 10.1074/jbc.M103001200 | doi-access = free }}</ref> * Myotonic dystrophy protein kinase<ref name = pmid9490724 /><ref name = pmid10625651>{{cite journal | vauthors = Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S | title = Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation | journal = J. Biol. Chem. | volume = 275 | issue = 2 | pages = 1095–104 | date = January 2000 | pmid = 10625651 | doi = 10.1074/jbc.275.2.1095| doi-access = free }}</ref> and * TRAF6.<ref name = pmid18950704>{{cite journal | vauthors = Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z | title = HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination | journal = Cell. Signal. | volume = 21 | issue = 1 | pages = 143–50 | date = January 2009 | pmid = 18950704 | doi = 10.1016/j.cellsig.2008.10.001 }}</ref>

== References == {{reflist}} {{Clear}}

== Further reading == {{refbegin | 2}} *{{cite journal | vauthors = Concannon CG, Gorman AM, Samali A | title = On the role of Hsp27 in regulating apoptosis. | journal = Apoptosis | volume = 8 | issue = 1 | pages = 61–70 | year = 2003 | pmid = 12510153 | doi = 10.1023/A:1021601103096 | s2cid = 18464958 }} *{{cite journal | vauthors = Elisei R, Weightman D, Kendall-Taylor P, Vassart G, Ludgate M | title = Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics. | journal = J. Endocrinol. Invest. | volume = 16 | issue = 7 | pages = 533–40 | year = 1993 | pmid = 8227983 | doi = 10.1007/bf03348900 | s2cid = 23857370 }} *{{cite journal | vauthors = Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. | journal = EMBO J. | volume = 17 | issue = 15 | pages = 4426–41 | year = 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }} *{{cite journal | vauthors = Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S | title = Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. | journal = J. Biol. Chem. | volume = 275 | issue = 2 | pages = 1095–104 | year = 2000 | pmid = 10625651 | doi = 10.1074/jbc.275.2.1095 | doi-access = free }} *{{cite journal | vauthors = Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B | title = A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. | journal = Eur. J. Hum. Genet. | volume = 9 | issue = 2 | pages = 121–9 | year = 2001 | pmid = 11313745 | doi = 10.1038/sj.ejhg.5200585 | doi-access = free }} *{{cite journal | vauthors = Nakagawa M, Tsujimoto N, Nakagawa H, Iwaki T, Fukumaki Y, Iwaki A | title = Association of HSPB2, a member of the small heat shock protein family, with mitochondria. | journal = Exp. Cell Res. | volume = 271 | issue = 1 | pages = 161–8 | year = 2001 | pmid = 11697892 | doi = 10.1006/excr.2001.5362 }} *{{cite journal | vauthors = Ito H, Kamei K, Iwamoto I, Inaguma Y, García-Mata R, Sztul E, Kato K | title = Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. | journal = J. Biochem. | volume = 131 | issue = 4 | pages = 593–603 | year = 2002 | pmid = 11926998 | doi = 10.1093/oxfordjournals.jbchem.a003139 | doi-access = free }} *{{cite journal | vauthors = Boxman IL, Kempenaar J, de Haas E, Ponec M | title = Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C. | journal = Exp. Dermatol. | volume = 11 | issue = 6 | pages = 509–17 | year = 2003 | pmid = 12473058 | doi = 10.1034/j.1600-0625.2002.110603.x | s2cid = 25384331 }} *{{cite journal | vauthors = Patel VM, Heinel LA, Provencio JJ, Vinall PE, Kramer MS, Rosenwasser RH | title = Validation of image analysis for enzyme histochemical and immunocytochemical staining. | journal = Biotechnic & Histochemistry | volume = 77 | issue = 4 | pages = 213–21 | year = 2003 | pmid = 12503731 | doi = 10.1080/714028196 }} *{{cite journal | vauthors = Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC | title = hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells. | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 18214–20 | year = 2003 | pmid = 12611892 | doi = 10.1074/jbc.M300126200 | doi-access = free }} *{{cite journal | vauthors = Yonekura N, Yokota S, Yonekura K, Dehari H, Arata S, Kohama G, Fujii N | title = Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines. | journal = Cell Death Differ. | volume = 10 | issue = 3 | pages = 313–22 | year = 2003 | pmid = 12700631 | doi = 10.1038/sj.cdd.4401169 | doi-access = free }} *{{cite journal | vauthors = Kantham L, Kerr-Bayles L, Godde N, Quick M, Webb R, Sunderland T, Bond J, Walder K, Augert G, Collier G | title = Beacon interacts with cdc2/cdc28-like kinases. | journal = Biochem. Biophys. Res. Commun. | volume = 304 | issue = 1 | pages = 125–9 | year = 2003 | pmid = 12705895 | doi = 10.1016/S0006-291X(03)00549-7 }} *{{cite journal | vauthors = Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY | title = Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72. | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3813–24 | year = 2003 | pmid = 12748284 | pmc = 155207 | doi = 10.1128/MCB.23.11.3813-3824.2003 }} *{{cite journal|author2-link=Richard Gaynor | vauthors = Park KJ, Gaynor RB, Kwak YT | title = Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35272–8 | year = 2003 | pmid = 12829720 | doi = 10.1074/jbc.M305095200 | doi-access = free }} *{{cite journal | vauthors = Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M | title = Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3. | journal = FEBS Lett. | volume = 546 | issue = 2–3 | pages = 307–14 | year = 2003 | pmid = 12832059 | doi = 10.1016/S0014-5793(03)00605-7 | s2cid = 35025906 | doi-access = free | bibcode = 2003FEBSL.546..307W }} *{{cite journal | vauthors = Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantôme A, Plenchette S, Khochbin S, Solary E, Garrido C | title = HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. | journal = Mol. Cell. Biol. | volume = 23 | issue = 16 | pages = 5790–802 | year = 2003 | pmid = 12897149 | pmc = 166315 | doi = 10.1128/MCB.23.16.5790-5802.2003 }} {{refend}}