HLA-DR8

{{cs1 config|name-list-style=vanc}} {| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px" |- | align="center" colspan="2" | 240px|Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen |- | align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">human major histocompatibility complex, class II, DR8</div> |- | bgcolor="#e7dcc3" | Haplotypes groups | bgcolor="#eeeeee" | DQA*01:DRB1*0801 to DQA*01:DRB1*0806 |- | colspan="2" bgcolor="#dddddd" | '''Structure''' (See HLA-DR) |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">alpha ''*0101''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">beta 1 ''*0801'' to ''*0806''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0801 DRB1*0801] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0802 DRB1*0802] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0803 DRB1*0803] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0804 DRB1*0804] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0805 DRB1*0805] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*0806 DRB1*0806] |- | colspan="2" bgcolor="#dddddd" | '''Shared data''' |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | chr.6 ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]'' |- |}

'''HLA-DR8''' (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

==Serology== {| border="0" cellspacing="0" cellpadding="0" align="center" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;" |+ DR8 serological recognition of the gene products of some DRB1*08 alleles<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref> |- style="background:#f0f0ff" | style="width:60px" | DRB1* || style="width:60px" | '''DR8''' | style="width:60px" | Sample |- style="background:#f0f0ff" | allele || % || size (N) |- | style = "background:#e8e8f8" | 0801 || 95 || 1076 |- | style = "background:#e8e8f8" | 0802 || 96 || 265 |- | style = "background:#e8e8f8" | 0803 || 88 || 230<ref>DR12 - 3%</ref> |- | style = "background:#e8e8f8" | 0804 || 93 || 186 |- | style = "background:#e8e8f8" | 0805 || >60 || 5 |- | style = "background:#e8e8f8" | 0806 || >75 || 13 |- |}

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

==Disease associations== DR8 is linked to papillary thyroid carcinomas,<ref>{{cite journal |vauthors=Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V | title = Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas. | journal = Clin Endocrinol | volume = 64 | issue = 2 | pages = 179–83 | year = 2006 | pmid = 16430717 | doi = 10.1111/j.1365-2265.2006.02445.x| s2cid = 22695710 }}</ref> early onset pauciarticular juvenile chronic arthritis,<ref>{{cite journal |vauthors=Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E | title = Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. | journal = Clin Exp Rheumatol | volume = 12 | pages = S7–14 | year = 1994| issue = Suppl 10 | pmid = 7955632}}</ref><ref>{{cite journal |vauthors=Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K | title = HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population. | journal = J Rheumatol | volume = 31 | issue = 11 | pages = 2281–5 | year = 2004 | pmid = 15517645}}</ref> primary biliary cirrhosis<ref>{{cite journal |vauthors=Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R | title = Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype. | journal = Hepatology | volume = 16 | issue = 6 | pages = 1404–8 | year = 1992 | pmid = 1359995 | doi = 10.1002/hep.1840160616| s2cid = 7200339 | doi-access = free }}</ref>

===by allele=== '''HLA-DRB1*0801''' is linked to primary biliary cirrhosis<ref name = "PBC">{{cite journal |vauthors=Charatcharoenwitthaya P, Lindor K | title = Current concepts in the pathogenesis of primary biliary cirrhosis. | journal = Ann Hepatol | volume = 4 | issue = 3 | pages = 161–75 | year = 2005| doi = 10.1016/S1665-2681(19)32061-7 | pmid = 16177655| doi-access = free }}</ref> In Mexicans DR8 is found more often in type-2 juvenile diabetes.<ref name="pmid17341285">{{cite journal |vauthors=Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, etal | title = HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children | journal = Pediatric Diabetes | volume = 8 | issue = 1 | pages = 5–10 | year = 2007 | pmid = 17341285 | doi = 10.1111/j.1399-5448.2006.00221.x| s2cid = 35352151 | doi-access = free }}</ref>

'''HLA-DRB1*0803''' is also linked to primary biliary cirrhosis<ref name = "PBC"/>

==Genetic Linkage== {| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=left width="240px" |-style="background:#f8f8f8" |align="center" colspan="4" | <div style="font-size:medium; line-height:120%;">DR8 Haplotypes</div> |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" | |-style="background:#f8f8f8" | rowspan = "1" bgcolor="#e7dcc3" | Haplotypes | bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *0801 || bgcolor="#eeeeee" | *0101 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | Haplotypes | bgcolor="#eeeeee"| *0401 || bgcolor="#eeeeee"| *0402 || bgcolor="#eeeeee" | *0801 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | Haplotypes | bgcolor="#eeeeee"| *0000 || bgcolor="#eeeeee"| *0000 || bgcolor="#eeeeee" | *0801 |- |}

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

==References== {{reflist}} {{DR serotypes}}

{{DEFAULTSORT:Hla-Dr8}} 8