Golph3

{{Short description|Protein-coding gene in the species Homo sapiens}} '''Golgi phosphoprotein 3''' ('''GOLPH3''') is a human protein encoded by GOLPH3 gene. It is a peripheral membrane protein of the Golgi that probably has a regulatory role in Golgi trafficking. <ref name="entrez">{{cite web | title = Entrez Gene: GOLPH3 golgi phosphoprotein 3 |url=https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=64083 }}</ref>

== Clinical significance ==

Golph 3 expression is associated with poor prognosis of various cancers of gastrointestinal tract, such as gastric and esophageal squamous cell carcinoma.<ref name=" pmid = 23056210 ">{{cite journal | author = Wang JH | title = High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis | journal = PLOS ONE | volume = 7 | issue = 10 | article-number = e45622 |date= 2013 | pmid = 23056210 | doi=10.1371/journal.pone.0045622 | pmc=3462781| bibcode = 2012PLoSO...745622W | doi-access = free }}</ref><ref name=" pmid = 23132295 ">{{cite journal | author = Hu BS | title = Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer. | journal = Tumour Biol. | volume = 34 |date=Feb 2013 | pmid = 23132295 | doi = 10.1007/s13277-012-0576-z | issue=1 | pages=515–20| s2cid = 6309770 }}</ref> Higher expression of GOLPH3 is reported to be associated with greater sensitivity of colorectal cancer to Fluorouracil therapy.<ref name=" pmid = 24444035 ">{{cite journal | author = Wang Z | title = GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy | journal = J. Transl. Med. | volume = 12 | issue = 1| page = 15 |date=Jan 2014 | pmid = 24444035 | doi = 10.1186/1479-5876-12-15 | pmc=4029222 | doi-access = free }}</ref>

==Notes and references== {{Reflist}}

Category:Membrane proteins