GRIPAP1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''GRIP1-associated protein 1''' is a protein that in humans is encoded by the ''GRIPAP1'' gene.<ref name="pmid10896157">{{cite journal | vauthors = Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL | title = GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex | journal = Neuron | volume = 26 | issue = 3 | pages = 603–17 | date = Aug 2000 | pmid = 10896157 | doi = 10.1016/S0896-6273(00)81198-8 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRIPAP1 GRIP1 associated protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=56850}}</ref>

== Function ==

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]<ref name="entrez"/>

== Interactions ==

GRIPAP1 has been shown to interact with GRIP1.<ref name=pmid10896157 />

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O | title = Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain | journal = DNA Res. | volume = 6 | issue = 5 | pages = 329–36 | year = 1999 | pmid = 10574461 | doi = 10.1093/dnares/6.5.329 | doi-access = free }} * {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }} * {{cite journal | vauthors = Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP | title = Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex | journal = J. Biol. Chem. | volume = 277 | issue = 4 | pages = 2396–405 | year = 2002 | pmid = 11704662 | doi = 10.1074/jbc.M106312200 | doi-access = free }} * {{cite journal | vauthors = Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK | title = The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15221–4 | year = 2002 | pmid = 11891216 | doi = 10.1074/jbc.C200112200 | doi-access = free | hdl = 2262/89271 | hdl-access = free }} * {{cite journal | vauthors = Ye B, Sugo N, Hurn PD, Huganir RL | title = Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody | journal = Neuroscience | volume = 114 | issue = 1 | pages = 217–27 | year = 2002 | pmid = 12207967 | doi = 10.1016/S0306-4522(02)00142-2 | s2cid = 39432674 }} * {{cite journal | vauthors = Coutts AS, MacKenzie E, Griffith E, Black DM | title = TES is a novel focal adhesion protein with a role in cell spreading | journal = J. Cell Sci. | volume = 116 | issue = Pt 5 | pages = 897–906 | year = 2003 | pmid = 12571287 | doi = 10.1242/jcs.00278 | doi-access = free }} * {{cite journal | vauthors = Nakata A, Ito T, Nagata M, Hori S, Sekimizu K | title = GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 | journal = Genes Cells | volume = 9 | issue = 11 | pages = 1125–35 | year = 2004 | pmid = 15507123 | doi = 10.1111/j.1365-2443.2004.00795.x | doi-access = free }} * {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | year = 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }} * {{cite journal | vauthors = Stinton LM, Selak S, Fritzler MJ | title = Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes | journal = Clin. Immunol. | volume = 116 | issue = 2 | pages = 108–17 | year = 2005 | pmid = 15897011 | doi = 10.1016/j.clim.2005.03.021 | url = https://zenodo.org/record/895661 }} {{refend}}