GMEB1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Glucocorticoid modulatory element-binding protein 1''' is a protein that in humans is encoded by the ''GMEB1'' gene.<ref name="pmid10386584">{{cite journal | vauthors = Thériault JR, Charette SJ, Lambert H, Landry J | title = Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein | journal = FEBS Lett | volume = 452 | issue = 3 | pages = 170–176 | date = Jul 1999 | pmid = 10386584 | doi = 10.1016/S0014-5793(99)00634-1 | s2cid = 20049223 }}</ref><ref name="pmid10523663">{{cite journal | vauthors = Christensen J, Cotmore SF, Tattersall P | title = Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites | journal = Mol Cell Biol | volume = 19 | issue = 11 | pages = 7741–50 | date = Nov 1999 | pmid = 10523663 | pmc = 84824 | doi = 10.1128/MCB.19.11.7741}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10691}}</ref>

== Function ==

This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.<ref name="entrez"/>

== Interactions ==

GMEB1 has been shown to interact with TRIM63.<ref name="pmid11927605">{{cite journal | vauthors = McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC | title = Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1 | journal = J Cell Biol | volume = 157 | issue = 1 | pages = 125–136 | year = 2002 | pmid = 11927605 | pmc = 2173255 | doi = 10.1083/jcb.200108089 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Jimenez-Lara AM, Heine MJ, Gronemeyer H | title = Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family | journal = FEBS Lett. | volume = 468 | issue = 2–3 | pages = 203–210 | year = 2000 | pmid = 10692587 | doi = 10.1016/S0014-5793(00)01209-6 | doi-access = free }} * {{cite journal | vauthors = Zeng H, Kaul S, Simons SS | title = Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins | journal = Nucleic Acids Res. | volume = 28 | issue = 8 | pages = 1819–1829 | year = 2000 | pmid = 10734202 | pmc = 102812 | doi = 10.1093/nar/28.8.1819 }} * {{cite journal | vauthors = Kaul S, Blackford JA, Chen J, Ogryzko VV, Simons SS | title = Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins | journal = Mol. Endocrinol. | volume = 14 | issue = 7 | pages = 1010–1027 | year = 2000 | pmid = 10894151 | doi = 10.1210/mend.14.7.0494 | doi-access = free }} * {{cite journal | vauthors = Burnett E, Christensen J, Tattersall P | title = A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters | journal = J. Mol. Biol. | volume = 314 | issue = 5 | pages = 1029–1039 | year = 2002 | pmid = 11743720 | doi = 10.1006/jmbi.2000.5198 }} * {{cite journal | vauthors = Kaul S, Blackford JA, Cho S, Simons SS | title = Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12541–12549 | year = 2002 | pmid = 11812797 | doi = 10.1074/jbc.M112330200 | doi-access = free }} * {{cite journal | vauthors = Surdo PL, Bottomley MJ, Sattler M, Scheffzek K | title = Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions | journal = Mol. Endocrinol. | volume = 17 | issue = 7 | pages = 1283–1295 | year = 2004 | pmid = 12702733 | doi = 10.1210/me.2002-0409 | doi-access = free }} * {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–1332 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }} * {{cite journal | vauthors = Tsuruma K, Nakagawa T, Shirakura H, Hayashi N, Uehara T, Nomura Y | title = Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain | journal = Biochem. Biophys. Res. Commun. | volume = 325 | issue = 4 | pages = 1246–1251 | year = 2005 | pmid = 15555560 | doi = 10.1016/j.bbrc.2004.10.145 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y | title = Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury | journal = J. Biol. Chem. | volume = 281 | issue = 16 | pages = 11397–11404 | year = 2006 | pmid = 16497673 | doi = 10.1074/jbc.M510597200 | doi-access = free | hdl = 2115/8511 | hdl-access = free }} * {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–1292 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }} {{refend}}