GALNT14

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Polypeptide N-acetylgalactosaminyltransferase 14''' is an enzyme that in humans is encoded by the ''GALNT14'' gene.<ref name="pmid12507512">{{cite journal |vauthors=Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H | title = Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 | journal = Biochem Biophys Res Commun | volume = 300 | issue = 3 | pages = 738–44 |date=Dec 2002 | pmid = 12507512 | doi =10.1016/S0006-291X(02)02908-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=79623}}</ref>

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM]<ref name="entrez" />

SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.<ref name="pmid21635146">{{cite journal |vauthors=Liang KH, Lin CC, Yeh CT | title = GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC. | journal = Pharmacogenomics | volume = 12 | issue = 7 | pages = 1061–73 |date=Jul 2011 | pmid = 21635146 | doi=10.2217/pgs.11.43}}</ref><ref name="pmid23959947">{{cite journal |vauthors=Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL, Hung CF | title = A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma. | journal = Int J Cancer | volume = 134 | issue = 5 | pages = 1214–1224 |date=Mar 2014 | pmid = 23959947 | doi=10.1002/ijc.28439| s2cid = 1262943 | doi-access = free }}</ref><ref name="pmid25295111">{{cite journal |vauthors=Liang KH, Yang PC, Yeh CT | title = Genotyping the GALNT14 gene by joint analysis of two linked single nucleotide polymorphisms using liver tissues for clinical and geographical comparisons.| journal = Oncol Lett | pmid = 25295111 | doi=10.3892/ol.2014.2507 | volume=8 | issue = 5| date=Nov 2014 | pages=2215–2220 | pmc=4186602}}</ref><ref name="pmid24940508">{{cite journal |vauthors=Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH, Yeh CT | title = GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma.| journal = Mol Clin Oncol | pmid = 24940508 | doi=10.3892/mco.2014.294 | volume=2 | issue = 4| date=Jul 2014 | pages=630–640 | pmc=4051573}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Wu C, Yao G, Zou M |title=N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 2 |pages= 360–5 |year= 2007 |pmid= 17434446 |doi= 10.1016/j.bbrc.2007.03.153 |display-authors=etal}} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} {{refend}}