GRB2 associated binding protein 3

'''GRB2 associated binding protein 3''' is a protein that in humans is encoded by the GAB3 gene. <ref name="ncbi"> {{cite web | title = GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ] | url = https://www.ncbi.nlm.nih.gov/gene/139716 | publisher = National Center for Biotechnology Information | access-date = 2019-08-03 }}</ref>

==Function==

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

== References ==

== Further reading ==

{{refbegin | 2}} *{{cite journal |vauthors=Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G |title=Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation |journal=Mol. Cell. Biol. |volume=22 |issue=11 |pages=3744–56 |year=2002 |pmid=11997510 |pmc=133813 |doi= 10.1128/mcb.22.11.3744-3756.2002}} *{{cite journal|last1=Sliz|first1=Anna|last2=Locker|first2=Kathryn C. S.|last3=Lampe|first3=Kristin|last4=Godarova|first4=Alzbeta|last5=Plas|first5=David R.|last6=Janssen|first6=Edith M.|last7=Jones|first7=Helen|last8=Herr|first8=Andrew B.|last9=Hoebe|first9=Kasper|title=Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy|journal=Science Immunology|volume=4|issue=38|year=2019|article-number=eaav3866|issn=2470-9468|doi=10.1126/sciimmunol.aav3866|pmid=31375526|pmc=7068803}}