'''Frank Simpson''' may refer to:
* Frank F. Simpson (1868–1948), American physician from Pennsylvania * Frank W. Simpson (1872–1929), American college football coach * Frank B. Simpson (1883–1966), American architect * Frank Simpson (British Army officer) (1899–1986), British Army General * Frank Simpson (cricketer) (1909–1992), British Army officer and cricketer * Frank Simpson (politician) (born 1945), American politician in the Oklahoma Senate * Nuke (Marvel Comics), real name: Frank Simpson, a supervillain from Marvel Comics
{{hndis|Simpson, Frank}}