{{short description|Swiss pharmacologist}} {{use dmy dates|date=January 2021}} {{Infobox academic | honorific_prefix = <!-- see MOS:CREDENTIAL and MOS:HONORIFIC --> | name = | honorific_suffix = | image = | image_size = | alt = | caption = | native_name = | native_name_lang = | birth_name = Françoise Ramel | birth_date = {{birth date|1931|09|20|df=yes}} | birth_place = | death_date = {{death date and age|2001|06|26|1931|09|20|df=yes}} | death_place = | death_cause = | citizenship = | other_names = | occupation = | period = | known_for = | title = | boards = <!--board or similar positions extraneous to main occupation--> | spouse = | partner = | children = | parents = | relatives = | awards = <!--notable national-level awards only--> | website = | education = | alma_mater = <!--will often consist of the linked name of the last-attended higher education institution--> | thesis_title = | thesis_url = | thesis_year = | school_tradition = | doctoral_advisor = | academic_advisors = | influences = <!--must be referenced from a third-party source--> | era = | discipline = Pharmacologist | sub_discipline = Expert on renal excretion | workplaces = University of Lausanne | doctoral_students = <!--only those with WP articles--> | notable_students = | main_interests = | notable_works = | notable_ideas = | influenced = <!--must be referenced from a third-party source--> | signature = | signature_alt = | signature_size = | footnotes = }}

'''Françoise Roch-Ramel''' (''née'' '''Ramel'''; 20 September 1931 – 26 June 2001)<ref>{{cite book|last1=Broe|first1=Marc E. de|last2=Porter|first2=George A.|last3=Bennett|first3=William M.|last4=Verpooten|first4=G. A.|title=Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals|date=2007|publisher=Springer Science & Business Media|isbn=9781402025860|page=XVI|url=https://books.google.com/books?id=T3qgBwAAQBAJ&q=Roch-Ramel,+Françoise&pg=PR16|accessdate=3 August 2017|language=en}}</ref> was a Swiss pharmacologist and a leading expert on the renal transport of organic anions and cations, especially uric acid.

== Life and work == Born to Edwin Ramel<ref name=":0">{{Cite web |title=Base de données des élites suisses {{!}} Roch-Ramel, Françoise (1931 - 2001) |url=https://www2.unil.ch/elitessuisses/personne.php?id=78688 |access-date=2023-10-21 |website=www2.unil.ch}}</ref> and raised in Château-d'Œx, Switzerland, her major research focus was the renal excretion of drugs and other xenobiotics. She was a professor at the Department of Pharmacology and Toxicology at the University of Lausanne, where she was employed in the early 1960s as an assistant of Professor George Peters.<ref name=":1">{{Cite journal |last1=Simmonds |first1=H. A. |author-link=Anne Simmonds |year=2004 |title=Dedication to Francoise Roch‐Ramel |journal=Nucleosides, Nucleotides and Nucleic Acids |volume=23 |issue=8–9 |pages=1081–1082 |doi=10.1081/NCN-200027357 |pmid=15571206 |s2cid=9825666}}</ref>

From 1975 to 1990, Roch-Ramel was an associate professor at the University of Lausanne.<ref name=":0" />

According to Simmonds, she studied "renal transport of organic anions and cations, especially uric acid, in the kidney" since the beginning of her academic career. To do so, Roch-Ramel created her own micro-puncture techniques to study ion transport in several different mammalian species including humans, cebus monkeys, pigs, rats, cats, rabbits, mongrel dogs and Dalmatian dogs. Of particular focus was the renal excretion of drugs and other xenobiotics. These studies included drug interactions and other clinical aspects of renal organic ion transport of cardiac glycosides, antibiotics and chemotherapy drugs.<ref name=":1" />

Her published work includes both academic papers as well as chapter contributions to many major texts including ''Diseases of the Kidney''. She was known to pay scrupulous attention to the methodology described in these publications and realized that the problems attached to the measurement of compounds, such as uric acid, had great importance on the validity of future academic studies.<ref name=":1" />

== Personal life == She married Alfred Roch in 1958.<ref name=":0" />

== Selected works ==

* Roch-Ramel, Françoise, Barbara Guisan, and Jacques Diezi. "Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles." ''Journal of Pharmacology and Experimental Therapeutics'' 280, no. 2 (1997): 839-845. * Burnier, Michel, Françoise Roch-Ramel, and Hans R. Brunner. "Renal effects of angiotensin II receptor blockade in normotensive subjects." ''Kidney international'' 49, no. 6 (1996): 1787-1790. * Roch-Ramel, Françoise. "An enzymic and fluorophotometric method for estimating urea concentrations in nanoliter specimens." ''Analytical biochemistry'' 21, no. 3 (1967): 372-381.

==References== {{reflist}}

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{{DEFAULTSORT:Roch-Ramel, Francoise}} Category:1931 births Category:2001 deaths Category:Swiss pharmacologists Category:People from Château-d'Œx Category:Academic staff of the University of Lausanne Category:20th-century Swiss scientists Category:Women pharmacologists Category:20th-century Swiss women scientists Category:Swiss biologists Category:Women biologists