Fluticasone

{{Short description|Chemical compound}} {{Use dmy dates|date=October 2022}} {{cs1 config |name-list-style=vanc |display-authors=6}} {{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 458449795 | image = Fluticasone.svg | image_class = skin-invert-image | width = 200

| Drugs.com = | pregnancy_AU =  | pregnancy_category = | routes_of_administration = Intranasal, inhalation, topical | ATC_prefix = D07 | ATC_suffix = AC17 | ATC_supplemental = {{ATC|R01|AD08}} {{ATC|R03|BA05}} {{ATC|R01|AD58}} | legal_AU =  | legal_CA = OTC

| IUPHAR_ligand = 6699 | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 90566-53-3 | PubChem = 5311101 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB00588 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4470631 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = CUT2W21N7U | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07981 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 5134 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1201396 | synonyms = 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; ''S''-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate

| IUPAC_name = ''S''-fluoromethyl (6''S'',8''S'',9''R'',10''S'',11''S'',13''S'',14''S'',16''R'',17''R'')-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[''a'']phenanthrene-17-carbothioate | C = 22 | H = 27 | F = 3 | O = 4 | S = 1 | SMILES = O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = MGNNYOODZCAHBA-GQKYHHCASA-N }}

'''Fluticasone''' is a manufactured glucocorticoid used to treat nasal congestion.<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=574–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1337–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=124–}}</ref><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/fluticasone.html|title = Fluticasone - FDA prescribing information, side effects and uses}}</ref><ref name="Briggs_et_al2012" /> Both the esters, fluticasone propionate (sold as Flovent) and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.<ref name="MortonHall2012" /><ref name="IndexNominum2000" /><ref name="Drugs.com" /><ref name="SprattoWoods2012" />

Fluticasone is on the World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> In 2023, it was the 26th most commonly prescribed medication in the United States, with more than 21{{nbsp}}million prescriptions,<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Fluticasone Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Fluticasone | access-date = 17 August 2025 }}</ref> although it is also sold over-the-counter (OTC).<ref>{{cite web |url=https://www.drugs.com/pro/fluticasone-nasal-spray.html |title=Fluticasone Nasal Spray |access-date=21 October 2022}}</ref>

== References == {{Reflist|refs= <ref name="Briggs_et_al2012">{{cite book | vauthors = Briggs GG, Freeman RK, Yaffe SJ | title = Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk | publisher = Lippincott Williams & Wilkins | page = 600 | year = 2012 | isbn = 978-1-4511-5359-0 | url = https://books.google.com/books?id=ScPvM03B3lUC&pg=PA600 }}</ref> <ref name="SprattoWoods2012">{{cite book | vauthors = Spratto GR, Woods AL | title = Delmar Nurse's Drug Handbook 2012 | publisher = Cengage Learning | page = 748 | year = 2012 | isbn = 978-1-111-31065-3 | url = https://books.google.com/books?id=x-f-kedg9ukC&pg=PA748 }}</ref> }}

{{Glucocorticoids and antiglucocorticoids}} {{Nasal preparations}} {{Asthma and copd_rx}} {{Glucocorticoid receptor modulators}} {{GlaxoSmithKline}} {{Portal bar | Medicine}} {{Authority control}}

Category:Anti-asthmatic agents Category:Diketones Category:Diols Category:Drugs acting on the respiratory system Category:Organofluorides Category:Drugs developed by GSK plc Category:Glucocorticoids Category:Pregnanes Category:Respiratory therapy Category:Thioesters Category:Over-the-counter drugs in the United States