Frizzled-5

Frizzled-5 (Fz-5) is a protein that in humans is encoded by the FZD5 gene.^[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.^[3]

References

1. ^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800
2. ^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929
3. ^ "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)"

Further reading

• He X, Saint-Jeannet JP, Wang Y (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A.". Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360. S2CID 36777692
• Finch PW, He X, Kelley MJ (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A.. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640
• Tanaka S, Akiyoshi T, Mori M (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A.. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618
• Tamai K, Semenov M, Kato Y (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature. 407 (6803): 530–5. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159
• Wiemann S, Weil B, Wellenreuther R (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res.. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun.. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
• Weidler C, Schaumburger J, Miller LE (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.". J. Rheumatol.. 31 (9): 1874–5. PMID 15338479
• Omoto S, Hayashi T, Kitahara K (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet.. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238
• Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.". Biochem. Biophys. Res. Commun.. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380
• Hillier LW, Graves TA, Fulton RS (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621
• Blumenthal A, Ehlers S, Lauber J (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.". Blood. 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161
• Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.". Int. J. Oncol.. 30 (3): 751–5. doi:10.3892/ijo.30.3.751. PMID 17273778

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-06-25. Retrieved 2008-12-04.