{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Frizzled-3''' '''(Fz-3)''' is a protein that in humans is encoded by the ''FZD3'' gene.<ref name="pmid10777673">{{cite journal |vauthors=Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M | title = Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21 | journal = Biochem Biophys Res Commun | volume = 271 | issue = 1 | pages = 8–14 | date = Jun 2000 | pmid = 10777673 | doi = 10.1006/bbrc.2000.2578 }}</ref><ref name="pmid10873558">{{cite journal |vauthors=Sala CF, Formenti E, Terstappen GC, Caricasole A | title = Identification, gene structure, and expression of human frizzled-3 (FZD3) | journal = Biochem Biophys Res Commun | volume = 273 | issue = 1 | pages = 27–34 | date = Jul 2000 | pmid = 10873558 | doi = 10.1006/bbrc.2000.2882 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7976}}</ref>
== Function ==
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.<ref name="entrez"/>
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.<ref name=" pmid24347548">{{cite journal |vauthors=Hua ZL, Smallwood PM, Nathans J | title = Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons | journal = eLife | volume = 2 | article-number = e01482 | date = Dec 2013 | pmid = 24347548 | pmc = 3865743 | doi = 10.7554/eLife.01482 | doi-access = free }}</ref><ref name=" pmid24799694">{{cite journal |vauthors=Hua ZL, Jeon S, Caterina MJ, Nathans J | title = Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system | journal = Proc Natl Acad Sci U S A | volume = 111 | issue = 29 | pages = E3005-14 | date = Jul 2014 | pmid = 24799694 | pmc = 4115534 | doi = 10.1073/pnas.1406399111 | bibcode = 2014PNAS..111E3005H | doi-access = free }}</ref>
==See also== * Frizzled
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | author = Katoh M | title = GIPC gene family (Review). | journal = Int. J. Mol. Med. | volume = 9 | issue = 6 | pages = 585–9 | year = 2002 | pmid = 12011974 | doi = 10.3892/ijmm.9.6.585 }} *{{cite journal |vauthors=Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 13 | pages = 6770–5 | year = 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 | bibcode = 1997PNAS...94.6770F | doi-access = free }} *{{cite journal |vauthors=Wright M, Aikawa M, Szeto W, Papkoff J | title = Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. | journal = Biochem. Biophys. Res. Commun. | volume = 263 | issue = 2 | pages = 384–8 | year = 1999 | pmid = 10491302 | doi = 10.1006/bbrc.1999.1344 }} *{{cite journal |vauthors=Hung BS, Wang XQ, Cam GR, Rothnagel JA | title = Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. | journal = J. Invest. Dermatol. | volume = 116 | issue = 6 | pages = 940–6 | year = 2001 | pmid = 11407985 | doi = 10.1046/j.1523-1747.2001.01336.x | doi-access = free }} *{{cite journal |vauthors=Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S | title = The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. | journal = Neurosci. Lett. | volume = 353 | issue = 1 | pages = 53–6 | year = 2004 | pmid = 14642436 | doi = 10.1016/j.neulet.2003.09.017 | s2cid = 109984 | url = http://ousar.lib.okayama-u.ac.jp/8380 | url-access = subscription }} *{{cite journal |vauthors=Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D | title = Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. | journal = Am. J. Med. Genet. B Neuropsychiatr. Genet. | volume = 129 | issue = 1 | pages = 16–9 | year = 2005 | pmid = 15274031 | doi = 10.1002/ajmg.b.30076 | s2cid = 33599450 }} *{{cite journal |vauthors=Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites. | journal = Protein Sci. | volume = 13 | issue = 10 | pages = 2819–24 | year = 2005 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }} *{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). | journal = Ophthalmic Genet. | volume = 25 | issue = 2 | pages = 81–90 | year = 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 | s2cid = 32817238 }} *{{cite journal |vauthors=Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H | title = Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. | journal = Journal of Neural Transmission | volume = 112 | issue = 2 | pages = 303–7 | year = 2005 | pmid = 15657645 | doi = 10.1007/s00702-004-0264-2 | s2cid = 22324795 }} {{refend}}
==External links== *{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3061 | title = Frizzled Receptors: FZD<sub>3</sub> | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2014-09-03 | archive-url = https://web.archive.org/web/20140903142704/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3061 }}
{{NLM content}} {{G protein-coupled receptors|g4}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}