{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''FUS-interacting serine-arginine-rich protein 1''' is a protein that in humans is encoded by the ''SFRS13A'' gene.<ref name="pmid9774382">{{cite journal | vauthors = Yang L, Embree LJ, Tsai S, Hickstein DD | title = Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing | journal = J. Biol. Chem. | volume = 273 | issue = 43 | pages = 27761–4 | date = November 1998 | pmid = 9774382 | doi = 10.1074/jbc.273.43.27761 | doi-access = free }}</ref><ref name="pmid11891055">{{cite journal | vauthors = Clinton JM, Chansky HA, Odell DD, Zielinska-Kwiatkowska A, Hickstein DD, Yang L | title = Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins | journal = Gene | volume = 284 | issue = 1–2 | pages = 141–7 | date = March 2002 | pmid = 11891055 | doi = 10.1016/S0378-1119(02)00382-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10772}}</ref>
== Function ==
This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.<ref name="entrez" />
== Interactions ==
FUSIP1 has been shown to interact with FUS.<ref name=pmid10779324>{{cite journal | vauthors = Yang L, Embree LJ, Hickstein DD | title = TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3345–54 | date = May 2000 | pmid = 10779324 | pmc = 85627 | doi = 10.1128/MCB.20.10.3345-3354.2000 }}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Yang L, Embree LJ, Hickstein DD | title = TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3345–54 | year = 2000 | pmid = 10779324 | pmc = 85627 | doi = 10.1128/MCB.20.10.3345-3354.2000 }} * {{cite journal | vauthors = Cowper AE, Cáceres JF, Mayeda A, Screaton GR | title = Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing | journal = J. Biol. Chem. | volume = 276 | issue = 52 | pages = 48908–14 | year = 2001 | pmid = 11684676 | doi = 10.1074/jbc.M103967200 | doi-access = free }} * {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }} * {{cite journal | vauthors = Shin C, Manley JL | title = The SR protein SRp38 represses splicing in M phase cells | journal = Cell | volume = 111 | issue = 3 | pages = 407–17 | year = 2002 | pmid = 12419250 | doi = 10.1016/S0092-8674(02)01038-3 | s2cid = 13215962 | doi-access = free }} * {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 21 | pages = 7437–47 | year = 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }} * {{cite journal | vauthors = Shin C, Feng Y, Manley JL | title = Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock | journal = Nature | volume = 427 | issue = 6974 | pages = 553–8 | year = 2004 | pmid = 14765198 | doi = 10.1038/nature02288 | bibcode = 2004Natur.427..553S | s2cid = 4423246 }} * {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }} * {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 | s2cid = 2371325 | doi-access = free | bibcode = 2004CBio...14.1436J }} * {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 | doi-access = free }} * {{cite journal | vauthors = Shin C, Kleiman FE, Manley JL | title = Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins | journal = Mol. Cell. Biol. | volume = 25 | issue = 18 | pages = 8334–43 | year = 2005 | pmid = 16135820 | pmc = 1234314 | doi = 10.1128/MCB.25.18.8334-8343.2005 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} {{refend}}
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