VEGFR1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox gene|FLT1}} '''Vascular endothelial growth factor receptor 1''' is a [[protein]] that in humans is encoded by the ''FLT1'' [[gene]].<ref name="pmid2158038">{{cite journal | vauthors = Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M | title = Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family | journal = Oncogene | volume = 5 | issue = 4 | pages = 519–24 | date = April 1990 | pmid = 2158038 }}</ref>

== Function ==

''FLT1'' is a member of [[VEGF receptor]] gene family. It encodes a [[receptor tyrosine kinase]] which is activated by [[VEGF-A]], [[VEGF-B]], and [[placental growth factor]]. The sequence structure of the ''FLT1'' gene resembles that of the ''FMS'' (now ''[[CSF1R]]'') gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.<ref>{{cite web | title = FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ] | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2321| publisher = [[National Center for Biotechnology Information]]}}</ref>

The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of [[white adipose tissue]] to [[brown adipose tissue]] as well as increase brown adipose [[angiogenesis]] in mice.<ref>{{cite journal | vauthors = Seki T, Hosaka K, Fischer C, Lim S, Andersson P, Abe M, Iwamoto H, Gao Y, Wang X, Fong GH, Cao Y | title = Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning | journal = The Journal of Experimental Medicine | volume = 215 | issue = 2 | pages = 611–626 | date = February 2018 | pmid = 29305395 | pmc = 5789413 | doi = 10.1084/jem.20171012 }}</ref>

Functional genetic variation in ''FLT1'' (rs9582036) has been found to affect [[Non-small-cell lung carcinoma|non-small cell lung cancer]] survival.<ref>{{cite journal | vauthors = Glubb DM, Paré-Brunet L, Jantus-Lewintre E, Jiang C, Crona D, Etheridge AS, Mirza O, Zhang W, Seiser EL, Rzyman W, Jassem J, Auman T, Hirsch FR, Owzar K, Camps C, Dziadziuszko R, Innocenti F | title = Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer | journal = Journal of Thoracic Oncology | volume = 10 | issue = 7 | pages = 1067–75 | date = July 2015 | pmid = 26134224 | pmc = 4494119 | doi = 10.1097/JTO.0000000000000549 }}</ref>

== Interactions ==

FLT1 has been shown to [[Protein-protein interaction|interact]] with [[PLCG1]]<ref name=pmid9398617>{{cite journal | vauthors = Cunningham SA, Arrate MP, Brock TA, Waxham MN | title = Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites | journal = Biochemical and Biophysical Research Communications | volume = 240 | issue = 3 | pages = 635–9 | date = November 1997 | pmid = 9398617 | doi = 10.1006/bbrc.1997.7719 | bibcode = 1997BBRC..240..635C }}</ref> and [[vascular endothelial growth factor B]] (VEGF-B).<ref name=pmid9751730>{{cite journal | vauthors = Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U | title = Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11709–14 | date = September 1998 | pmid = 9751730 | pmc = 21705 | doi = 10.1073/pnas.95.20.11709 | bibcode = 1998PNAS...9511709O | doi-access = free }}</ref><ref name=pmid10409677>{{cite journal | vauthors = Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K | title = Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 30 | pages = 21217–22 | date = July 1999 | pmid = 10409677 | doi = 10.1074/jbc.274.30.21217 | doi-access = free }}</ref>

== See also == * [[VEGF receptors]]

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Petrova TV, Makinen T, Alitalo K | title = Signaling via vascular endothelial growth factor receptors | journal = Experimental Cell Research | volume = 253 | issue = 1 | pages = 117–30 | date = November 1999 | pmid = 10579917 | doi = 10.1006/excr.1999.4707 }} * {{cite journal | vauthors = Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M | title = Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction | journal = Annals of the New York Academy of Sciences | volume = 902 | issue = 1 | pages = 201–5; discussion 205–7 | date = May 2000 | pmid = 10865839 | doi = 10.1111/j.1749-6632.2000.tb06314.x | bibcode = 2000NYASA.902..201S | s2cid = 11488629 }} * {{cite journal | vauthors = Boyd AW, Lackmann M | title = Signals from Eph and ephrin proteins: a developmental tool kit | journal = Science's STKE | volume = 2001 | issue = 112 | pages = re20 | date = December 2001 | pmid = 11741094 | doi = 10.1126/stke.2001.112.re20 | s2cid = 2952319 }} * {{cite journal | vauthors = Luttun A, Tjwa M, Carmeliet P | title = Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders | journal = Annals of the New York Academy of Sciences | volume = 979 | pages = 80–93 | date = December 2002 | pmid = 12543719 | doi = 10.1111/j.1749-6632.2002.tb04870.x | s2cid = 73356935 }} * {{cite journal | vauthors = Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA | title = Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia | journal = Pediatric Research | volume = 57 | issue = 5 Pt 2 | pages = 1R–7R | date = May 2005 | pmid = 15817508 | doi = 10.1203/01.PDR.0000159567.85157.B7 | doi-access = free }} * {{cite journal | vauthors = Shibuya M | title = Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis | journal = Angiogenesis | volume = 9 | issue = 4 | pages = 225–30; discussion 231 | year = 2007 | pmid = 17109193 | doi = 10.1007/s10456-006-9055-8 | s2cid = 20495537 }} * {{cite journal | vauthors = Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M | title = Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review | journal = Obstetrics and Gynecology | volume = 109 | issue = 1 | pages = 168–80 | date = January 2007 | pmid = 17197602 | doi = 10.1097/01.AOG.0000249609.04831.7c | s2cid = 24187545 }} * {{cite journal | vauthors = López-Novoa JM | title = Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia | journal = Nephrology, Dialysis, Transplantation | volume = 22 | issue = 3 | pages = 712–4 | date = March 2007 | pmid = 17210583 | doi = 10.1093/ndt/gfl768 | doi-access = free }} * {{cite journal | vauthors = Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P | title = Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration | journal = The Journal of Neuroscience | volume = 28 | issue = 42 | pages = 10451–9 | date = October 2008 | pmid = 18923022 | doi = 10.1523/JNEUROSCI.1092-08.2008 | pmc = 6671326 | doi-access = free }} * {{cite journal | vauthors = Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K | title = Vascular endothelial growth factors VEGF-B and VEGF-C | journal = Journal of Cellular Physiology | volume = 173 | issue = 2 | pages = 211–5 | date = November 1997 | pmid = 9365524 | doi = 10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H | s2cid = 2930599 }} * {{cite journal | vauthors = Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D | title = VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche | journal = Nature | volume = 438 | issue = 7069 | pages = 820–7 | date = December 2005 | pmid = 16341007 | pmc = 2945882 | doi = 10.1038/nature04186 | bibcode = 2005Natur.438..820K }} {{refend}}

{{PDB Gallery|geneid=2321}} {{Growth factor receptors}} {{Tyrosine kinases}} {{Enzymes}} {{Portal bar|Biology|border=no}}

[[Category:Tyrosine kinase receptors]] [[Category:Genes on human chromosome 13]]