{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''FAST kinase domain-containing protein 3''' (FASTKD3) is a protein that in humans is encoded by the ''FASTKD3'' gene on chromosome 5.<ref name="uniprot">UniProt: {{UniProt|Q9NYY8}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FAST kinase domains 2 | url = https://www.ncbi.nlm.nih.gov/gene/22868}}</ref> This protein is part of the Fas-activated serine/threonine kinase domain (FASTKD) containing protein family, which is known for regulating the energy balance of mitochondria under stress.<ref name="pmid20869947">{{cite journal | vauthors = Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P | title = Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration | journal = Biochemical and Biophysical Research Communications | volume = 401 | issue = 3 | pages = 440–6 | date = Oct 2010 | pmid = 20869947 | doi = 10.1016/j.bbrc.2010.09.075 | pmc=2963690}}</ref><ref name="pmid21444724">{{cite journal | vauthors = Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH | title = A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2 | journal = Molecular and Cellular Biology | volume = 31 | issue = 11 | pages = 2287–98 | date = Jun 2011 | pmid = 21444724 | doi = 10.1128/MCB.01381-10 | pmc=3133243}}</ref>
== Structure ==
FASTKD3 shares structural characteristics of the FASTKD family, including an N-terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and a RNA-binding domain (RAP).<ref name="pmid20869947"/><ref name="pmid21444724"/> The mitochondrial targeting domain directs FASTKD3 to be imported into the mitochondria. Though the functions of the C-terminal domains are unknown, RAP possibly binds RNA during trans-splicing.<ref name="pmid20869947"/>
== Function ==
As a member of the FASTKD family, FASTKD3 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD3 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. FASTKD3 has been proposed to regulate energy production by serving as a scaffold protein that brings together RNA processing/translation and respiratory components.<ref name="pmid20869947"/>
== Clinical Significance ==
Currently, FASTKD3 has not been linked to any disease. (Dated: September 17, 2015)
== Interactions ==
FASTKD3 has been shown to interact with: *FASTKD2; *Fatty acid beta oxidation pathway proteins (ACADVL, ECHS1, HADHA, HADHB, ACAA2); *Amino acid catabolic pathways proteins (MCCC1, MCCC2, GLUD1, HIBADH, CPS1); *Amino acid biosynthesis proteins (PYCR1, PYCR2, ALDH18A1, SHMT2, GLS); *TCA cycle proteins (IDH3A, IDH2, SUCLG2, DLST); *Respiratory chain proteins (NDUFS1, SDHA, ATP5F1A, ETFA, ETFB); *Mitochondrial RNA processing proteins (LRPPRC, DHX30, PNPT1); and *Mitochondrial translation proteins (TUFM, GFM1, IARS2, MRPS22, TARS2, MRPS2, PTCD1, MTO1, MRPS31).<ref name="pmid20869947"/>
== References == {{reflist}}
== Further reading == {{refbegin}} * {{cite journal | vauthors = Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y | title = Proteomic dissection of the von Hippel-Lindau (VHL) interactome | journal = Journal of Proteome Research | volume = 10 | issue = 11 | pages = 5175–82 | date = Nov 2011 | pmid = 21942715 | pmc = 3208728 | doi = 10.1021/pr200642c }} * {{cite journal | vauthors = Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P | title = Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration | journal = Biochemical and Biophysical Research Communications | volume = 401 | issue = 3 | pages = 440–6 | date = Oct 2010 | pmid = 20869947 | pmc = 2963690 | doi = 10.1016/j.bbrc.2010.09.075 }} {{refend}}
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Category:Genes Category:Human proteins
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