{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''FAM114A2''' (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
{| class="wikitable" border="1" |- ! Species ! Accession # ! Identity |- | macaca mulatta | XM_001102467 | 78.1% |- | Pan troglodytes | XM_518045 | 89.7% |- | bos taurus | NP_001033166 | 85.6% |- | Pongo abelii | XM_002816109 | 87.8% |- | Mus musculus | NM_026342.3 | 79% |- | Callithrix jacchus | XP_002744467 | 94.7% |}
==Protein== The FAM114A2 protein is 505 amino acids long<ref name=ncbi>[https://www.ncbi.nlm.nih.gov/nuccore/NM_018691.2 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI]</ref> with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.<ref>Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#{{Dead link|date=August 2019 |bot=InternetArchiveBot |fix-attempted=yes }}!</ref> It is predicted to stay in the nucleus after translation <ref>[http://psort.hgc.jp/ PSORT WWW Server]</ref> There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 <ref>STRING: http://string-db.org/newstring_cgi/show_network_section.pl {{Webarchive|url=https://web.archive.org/web/20130515112426/http://string-db.org/newstring_cgi/show_network_section.pl |date=2013-05-15 }}.</ref> This protein is thought to include a P loop<ref>{{Cite web|url=http://string-db.org/newstring_cgi/show_textmining_evidence.pl.|title=STRING: Functional protein association networks|access-date=2011-05-07|archive-date=2021-10-26|archive-url=https://web.archive.org/web/20211026211141/https://string-db.org/newstring_cgi/show_textmining_evidence.pl.|url-status=dead}}</ref> that suggests a role in ATP- and/or GTP-binding <ref>{{cite journal|pmid=2126155 | volume=15 | issue=11 | title=The P-loop--a common motif in ATP- and GTP-binding proteins |date=November 1990 | journal=Trends Biochem. Sci. | pages=430–4 | vauthors=Saraste M, Sibbald PR, Wittinghofer A | doi=10.1016/0968-0004(90)90281-f}}</ref>
==Gene== The FAM114A2 gene is located on chromosome 5 (5q31-33).<ref name=www.genecards.org>[https://www.genecards.org/cgi-bin/carddisp.pl?gene=FAM114A2&search=c5orf3 FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody]</ref> This gene has 14 exons spanning through its sequence.<ref name=ncbi/> The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.<ref name=ncbi/> It is expressed at high levels in most tissues of the human body.<ref name=www.genecards.org/> It is also highly expressed in tissues in the human brain <ref>Allen Brain Atlas: http://human.brain-map.org/search?type=mi {{Webarchive|url=https://web.archive.org/web/20110818034600/http://human.brain-map.org/search?type=mi |date=2011-08-18 }}</ref>
== References == {{reflist}}
==External links== * {{UCSC gene info|FAM114A2}}
==Further reading== {{refbegin | 2}} *{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }} *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }} *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} {{refend}}
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