FAAH2

'''Fatty acid amide hydrolase 2''' or '''FAAH2''' is a member of the serine hydrolase family of enzymes.<ref name="pmid17015445">{{cite journal | vauthors = Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF | title = A second fatty acid amide hydrolase with variable distribution among placental mammals | journal = The Journal of Biological Chemistry | volume = 281 | issue = 48 | pages = 36569–78 | date = December 2006 | pmid = 17015445 | doi = 10.1074/jbc.M606646200 | doi-access = free }}</ref>

Fatty acid amide hydrolase 2 degrades many types of fatty acid amides, including the sleep-inducing oleamide and endocannabinoids such as anandamide.<ref name=uniprot>{{cite web |title=UniProt Q6GMR7 |url=https://www.uniprot.org/uniprotkb/Q6GMR7/ |website=UniProt |language=en}}</ref> It has a tissue distribution quite distinct from the paralogous FAAH (or "FAAH1"). Compared to FAAH, it is less active on N-acyl ethanolamines (e.g. anandamide) and N-acyl taurines.<ref name=pmid17015445/>

OrthoDB indicates that FAAH2 (as a gene distinct from FAAH) has orthologs all across Metazoa, with the notable exclusion of rodents.<ref>{{cite web |title=9606_0:0045e6|url=https://www.orthodb.org/?query=9606_0%3A0045e6 |website=OrthoDB {{!}} genes orthologs {{!}} Zdobnov lab }}</ref> This complicates the translation of FAAH-related results from rodent models to human biology.<ref name=pmid17015445/>

== Clinical significance == Defects in this enzyme have been associated with neurologic and psychiatric disorders. Specifically, a Canadian male with autism, anxiety, severe dysarthria, and a number of other issues have a Ala458Ser mutation inherited from his healthy carrier mother. In cell models this mutation is associated with a decreased function of this gene. This patient has a very abnormal blood lipid composition consistent with a loss of function.<ref name="pmid25885783">{{cite journal | vauthors = Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, Testa D, Dubin D, Carbonetti G, Glynn SE, Sayson B, Robinson WP, Han B, Wishart D, Ross CJ, Wasserman WW, Hurwitz TA, Sinclair G, Kaczocha M | display-authors = 6 | title = Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms | journal = Orphanet Journal of Rare Diseases | volume = 10 | article-number = 38 | date = March 2015 | pmid = 25885783 | pmc = 4423390 | doi = 10.1186/s13023-015-0248-3 | doi-access = free }}</ref>

ClinVar reports a missense mutation that produces an early stop codon (Trp392Ter) is associated with Meckel-like syndrome.<ref>{{cite web |title=NM_174912.4(FAAH2):c.1175G>A (p.Trp392Ter) AND Meckel-like syndrome - ClinVar - NCBI |url=https://www.ncbi.nlm.nih.gov/clinvar/RCV001844344/ |website=www.ncbi.nlm.nih.gov}}</ref>

UniProt Variant Viewer lists a large number of other variants found in surveyed human genomes. Several are predicted to have consequences by PolyPhen and/or SIFT.<ref name=uniprot/>

== References == {{Reflist}}

== External links == * [https://www.proteinatlas.org/ENSG00000165591-FAAH2 Fatty acid amide hydrolase 2 (FAAH2) The Human Protein Atlas]

Category:Integral membrane proteins Category:EC 3.5.1