{{Short description|Canadian-American physician (1918–2014)}} {{For|the Dr. Farber, after whom Farber disease is named|Sidney Farber}} '''Emmanuel Farber''' (October 19, 1918, Toronto, Canada – August 3, 2014, Columbia, South Carolina) was a Canadian-American physician, pathologist, biochemist, and oncologist. He is known for his research on the biochemistry of carcinogenesis.<ref name=obitAACR>{{cite web|title=Emmanuel Farber, MD, PhD, deceased (1918-2014), Fellow of the Academy of the AACR, Class of 2013|website=American Association for Cancer Research (AACR)|url=https://www.aacr.org/professionals/membership/aacr-academy/fellows/emmanuel-farber-md-phd/}}</ref><ref>{{Cite web |title=Cancer Research Pioneer Emmanuel Farber Dies at 95 |url=https://www.medscape.com/viewarticle/829767 |access-date=2023-11-02 |website=Medscape |language=en}}</ref>
==Biography== His parents emigrated from Russia to Canada and the United States. His sister Sophie became a concert pianist<ref name=JewishFoundation>{{cite web|title=Emmanuel Farber|website=Jewish Foundation of Greater Toronto|url=https://www.jewishfoundationtoronto.com/book-of-life-stories/-00farberemmanuel}}</ref><ref>{{cite web|website=New Jersey Hills Media Group|date=December 15, 2004|url=https://www.newjerseyhills.com/sophie-goldblatt-was-90-former-musician/article_dbbcfd0d-2dac-576f-841c-5e0eaf8c7838.html|title=Sophie Goldblatt, was 90, former musician }}</ref> and his brother Lionel earned a Ph.D. at the University of Toronto<ref name=JewishFoundation/> and became a professor of biochemistry at the University of California, San Francisco.<ref name=JewishFoundation/><ref>{{cite book|chapter=Chapter 2. ''Freshness Tests'' by Lionel Farber|pages=65–126|chapter-url=https://books.google.com/books?id=hTj2mUb5OEcC&pg=PA65| title=Fish as Food Volume 4: Processing: Part 2 | isbn=9780323146869 | editor=Borgstrom, Georg | date=2 December 2012 |publisher=Elsevier }}</ref> Emmanuel Farber graduated in 1942 with an M.D. from the University of Toronto Faculty of Medicine.<ref name=obitAACR/> In April 1942 he married Ruth Wilma Diamond. From 1942 to 1946 he served as a captain in the Royal Canadian Army Medical Corps. From 1942 to 1943 he did his medical internship and medical residency in pathology at Hamilton General Hospital. Supported from 1947 to 1949 by a fellowship in cancer research from the American Cancer Society, he became a graduate student in biochemistry at the University of California, Berkeley, where he graduated with a Ph.D. in biochemistry in 1949.<ref name=Laconi/> In 1948 he learned about hepatology, pathology, and oncology under the supervision of Hans Popper at Cook County Hospital.<ref>{{cite web|url=https://academictree.org/chemistry/peopleinfo.php?pid=818002| title=Chemistry Tree - Emmanuel Farber }}</ref> From 1950 to 1961 Farber a faculty member at Tulane University, starting as an instructor and resigning as an associate professor.<ref name=Laconi>{{cite journal|doi=10.1158/0008-5472.CAN-14-3457|title=Emmanuel Farber: In Memoriam (1918–2014) |year=2015 |last1=Laconi |first1=Ezio |last2=Hegele |first2=Richard G. |last3=Lieberman |first3=Michael W. |last4=Srinivasan |first4=Rajalakshmi |last5=Dittakavi |first5=Sarma S.R. |journal=Cancer Research |volume=75 |issue=2 |pages=243–244 |doi-access=free }}</ref> Emmanuel and Ruth's daughter, Naomi Beth, was born in 1956. From 1961 to 1970 at the University of Pittsburgh School of Medicine, he was a professor of pathology and chair of the department of pathology and also a professor in the department of biochemistry. From 1970 to 1975 he was the director of the Fels Research Institute (now called the Fels Cancer Institute for Personalized Medicine) and a professor of pathology and biochemistry at the Temple University School of Medicine. <ref name=Laconi/> From 1975 to 1985 he was a professor of pathology and chair of the department of pathology at the University of Toronto Faculty of Medicine, as well as a professor in the University of Toronto's department of biochemistry. In 1985 he retired as professor emeritus,<ref name=obitAACR/> but continued working in Toronto until his wife Ruth died in 1993.<ref name=JewishFoundation/>
Farber served on the editorial boards of several journals, including ''The American Journal of Pathology'', ''Laboratory Investigation''; ''The Journal of Histochemistry and Cytochemistry''; ''Teratogenesis, Carcinogenesis, and Mutagenesis''; ''The International Journal of Cancer''; ''Hepatology'';<ref>{{cite web|title=Emmanuel Farber, Experimental Pathologist, Dies at Age 95|date=August 8, 2014|website=Cancer Letter|url=https://cancerletter.com/free/20140808_6/}}</ref> and ''Chemico-Biological Interactions''.<ref>{{cite book|title=Who's Who in the World|year=1970|publisher=Marquis|location=Chicago|page=291|url=https://books.google.com/books?id=7YjEw8V3OrgC&q=chemico-biological+interactions,+emmanuel+farber|isbn=9780837911014}}</ref> From 1961 to 1964 he served on the Surgeon General's Advisory Committee on Smoking and Health.<ref name=Laconi/> The committee's 1964 report was of enormous importance in preventing disease related to tobacco smoking and environmental tobacco smoke.<ref name=NYTimes/><ref name=Laconi/><ref>{{cite magazine|author=Jenkins, Nash|date=August 5, 2014|title=Doctor Who Contributed to Early Research on Smoking Has Died|magazine=Time Magazine|url=https://time.com/3081438/emmanuel-farber-smoking-cancer-died/}}</ref>
Farber's research demonstrated that carcinogens can bind to DNA, causing specific DNA adducts that promote cancer. He and his colleagues showed that cancer can be induced in the livers of laboratory animals by a step-by-step series of chemical treatments.<ref name=NYTimes>{{cite web|url=https://www.legacy.com/us/obituaries/nytimes/name/emmanuel-farber-obituary?pid=171998401| title=Emmanuel Farber's Obituary (2014) New York Times | website=Legacy.com }}</ref> He was the author or coauthor of over 400 scientific publications.<ref name=Laconi/>
He was elected in 1955 a fellow of the American Association for the Advancement of Science.<ref>{{cite web|title=Historic Fellows|website=American Association for the Advancement of Science|url=https://www.aaas.org/fellows/historic}}</ref> He was elected in 1980 a fellow of the Royal Society of Canada<ref>{{cite web|title=Find an RSC Member|website=Royal Society of Canada/Société royale du Canada|date=13 June 2019 |url=https://rsc-src.ca/en/find-rsc-member}}</ref> and in 2013 an inaugural fellow of the Academy of the American Association for Cancer Research (AACR). He served as the AACR's president from 1972 to 1973. In 1973 he was also the president of the American Society for Experimental Pathology (which is now part of the American Society for Investigative Pathology).<ref name=obitAACR/> He gave in 1982 the Rous-Whipple Award Lecture<ref>{{cite journal|author=Farber, E.|title=Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture|journal=The American Journal of Pathology|volume=108|issue=3|year=1982|pages=270–275|pmid=6810701|pmc=1916049}}</ref> and in 1984 the G.H.A. Clowes Memorial Lecture.<ref>{{cite journal|author=Farber, Emmanuel|title=Cellular biochemistry of the stepwise development of cancer with chemicals: GHA Clowes memorial lecture|journal=Cancer Research|volume=44|issue=12_Part_1|year=1984|pages=5463–5474|pmid=6388826 |url=https://aacrjournals.org/cancerres/article/44/12_Part_1/5463/488104/Cellular-Biochemistry-of-the-Stepwise-Development}}</ref> In 1995 he shared the ASIP Gold-Headed Cane Award with Paul Eston Lacy.<ref>{{cite web|title=ASIP Gold-Headed Cane Award|website=American Society for Investigative Pathology|url=https://www.asip.org/membership-community/awards-honors/meritorious-awards/asip-gold-headed-cane-award/}}</ref>
In May 2000 Farber married Henrietta Schleider ''née'' Keller (1915–2011).<ref>{{cite web|title=Henrietta Keller Farber 1915-2011|website=legacy.com|url=https://www.legacy.com/amp/obituaries/tributes/178549999}}</ref> Upon his death in 2014 he was survived by his daughter.<ref name=NYTimes/> He is buried in the Hebrew Benevolent Society Cemetery in Columbia, South Carolina.<ref>{{cite web|url=https://www.dignitymemorial.com/obituaries/columbia-sc/emmanuel-farber-6071229|title=Emmanuel Farber. Obituary - Columbia, SC }}</ref> His daughter Naomi married Steven E. Grosby (a professor of religion) and became a professor of social work at the University of South Carolina.<ref name=JewishFoundation/>
==Selected publications== * {{cite book|doi=10.1016/S0065-230X(08)60986-0|title=Ethionine Carcinogenesis |series=Advances in Cancer Research |year=1963 |last1=Farber |first1=Emmanuel |volume=7 |pages=383–474 |pmid=14153769 |isbn=9780120066070 }} * {{cite book|doi=10.1016/B978-0-444-41542-4.50014-6|chapter=The Pathology of Experimental Liver Cell Cancer |title=Liver Cell Cancer |year=1976 |last1=Farber |first1=Emmanuel |pages=243–277 |isbn=9780444415424 }} * {{cite book|doi=10.1016/S0065-230X(08)60658-2|title=The Sequential Analysis of Cancer Development |series=Advances in Cancer Research |year=1980 |last1=Farber |first1=Emmanuel |last2=Cameron |first2=Ross |volume=31 |pages=125–226 |pmid=6250325 |isbn=9780120066315 }} * {{cite journal|pmid=6101993|url=https://aacrjournals.org/cancerres/article/40/4/1157/484627/Induction-of-Resistant-Hepatocytes-as-a-New|year=1980 |last1=Tsuda |first1=H. |last2=Lee |first2=G. |last3=Farber |first3=E. |title=Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens |journal=Cancer Research |volume=40 |issue=4 |pages=1157–1164 }} * {{cite journal|doi=10.1016/0304-419X(80)90002-5|title=The sequential analysis of liver cancer induction |year=1980 |last1=Farber |first1=Emmanuel |journal=Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |volume=605 |issue=2 |pages=149–166 |pmid=6994812 }} * {{cite journal|pmid=6291753|url=https://aacrjournals.org/cancerres/article/43/1/188/486872/Promotion-of-Liver-Cancer-Development-by-Brief|year=1983 |last1=Solt |first1=D. B. |last2=Cayama |first2=E. |last3=Tsuda |first3=H. |last4=Enomoto |first4=K. |last5=Lee |first5=G. |last6=Farber |first6=E. |title=Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride |journal=Cancer Research |volume=43 |issue=1 |pages=188–191 }} * {{cite journal|doi=10.1093/carcin/5.10.1367|title=The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens |year=1984 |last1=Ghoshal |first1=Amiya K. |last2=Farber |first2=Emmanuel |journal=Carcinogenesis |volume=5 |issue=10 |pages=1367–1370 |pmid=6488458 }} * {{cite journal|doi=10.1002/1097-0142(19881015)62:1+<1676::AID-CNCR2820621303>3.0.CO;2-1|year=1988 |volume=62 |issue=S1 |last1=Farber |first1=Emmanuel |title=Cancer development and its natural history a cancer prevention perspective |journal=Cancer |pages=1676–1679 |pmid=3167785 |s2cid=35730301 }} 1988 * {{cite journal|doi=10.1093/carcin/13.3.433|title=The cancer-initiating potential of the fumonisin B mycotoxins |year=1992 |last1=Gelderblom |first1=W.C.A. |last2=Semple |first2=E. |last3=Marasas |first3=W.F.O. |last4=Farber |first4=E. |journal=Carcinogenesis |volume=13 |issue=3 |pages=433–437 |pmid=1547534 }} * {{cite journal|pmid=7680728|year=1993 |last1=Ghoshal |first1=A. K. |last2=Farber |first2=E. |title=Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: A new perspective |journal=Laboratory Investigation; A Journal of Technical Methods and Pathology |volume=68 |issue=3 |pages=255–260 }} ==Books== * {{cite book|editor=Faber, E.|editor2=Fisher, Murray M.|title=Toxic Injury of the Liver (Part A)|series=Liver: Normal Function and Disease Ser., Vol. 2|year=1980|publisher=Marcel Dekker|url=https://archive.org/details/toxicinjuryofliv0000unse/page/n5/mode/2up|isbn=0824768388}} * {{cite book|editor=Faber, E.|editor2=Fisher, Murray M.|title=Toxic Injury of the Liver (Part B)|series=Liver: Normal Function and Disease Ser., Vol. 2|year=1980|publisher=Marcel Dekker|isbn=0824768396}}
==References== <references/>
==External links== * {{findagrave|id=199125549|name=Dr Emmanuel "Manny" Farber}}
{{authority control}} {{DEFAULTSORT:Farber, Emmanuel}} Category:1918 births Category:2014 deaths Category:20th-century Canadian medical doctors Category:21st-century Canadian medical doctors Category:20th-century American medical doctors Category:21st-century American medical doctors Category:Canadian pathologists Category:Canadian biochemists Category:Canadian oncologists Category:American pathologists Category:American biochemists Category:American oncologists Category:University of Toronto alumni Category:University of California, Berkeley alumni Category:Tulane University faculty Category:University of Pittsburgh faculty Category:Temple University faculty Category:Academic staff of the University of Toronto Category:Fellows of the American Association for the Advancement of Science Category:Fellows of the Royal Society of Canada Category:ASIP gold-headed cane award