{{short description|American chemist}} '''Derek Lowe''' is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry. Lowe has published a blog about this field, "In the Pipeline", since 2002<ref>{{cite news|last1=Weintraub|first1=Karen|title=Derek Lowe: Chemist puts a human face on drug development|url=https://www.statnews.com/2016/03/05/derek-lowe-chemist-blogger/|work=STAT|date=5 March 2016}}</ref> and is a columnist for the Royal Society of Chemistry's ''Chemistry World''.<ref>{{cite web | url = https://www.chemistryworld.com/derek-lowe/1294.bio | title = Derek Lowe | publisher = Chemistry World }}</ref>
== Biography == Lowe (born in Harrisburg, Arkansas) got his BA from Hendrix College and his PhD in organic chemistry from Duke University on synthesis of natural products, before researching for a year in Germany on a Humboldt Fellowship.<ref>{{cite web|title=Odyssey Medal: Derek Lowe|url=https://www.hendrix.edu/odysseymedal/default.aspx?id=68045|publisher=Hendrix College|language=en|date=2014}}</ref><ref name=linkedin/>
Lowe was one of the first people to blog from inside the pharmaceutical industry, with the approval of his supervisor and the company legal department,<ref>{{cite web|archive-url=https://web.archive.org/web/20110514113329/http://www.the-scientist.com/article/display/15665/|archive-date=2011-05-14 |url=http://www.the-scientist.com/2005/8/1/37/1/| title=The Power of the Blog | publisher = The Scientist | date=August 2005|first = David | last=Secko}}</ref> and one of the first science bloggers.<ref>{{cite web |url=http://blogs.discovermagazine.com/gnxp/2010/08/the-oldest-science-blog-of-all/ |title=The oldest science blog of all? | Gene Expression | Discover Magazine |publisher=Blogs.discovermagazine.com |date=2010-08-24 |access-date=2012-02-22 |archive-date=2012-10-16 |archive-url=https://web.archive.org/web/20121016140950/http://blogs.discovermagazine.com/gnxp/2010/08/the-oldest-science-blog-of-all/ |url-status=dead }}</ref> By 2006, his blog had between 3,000 and 4,000 visitors per day during the workweek; he covered business matters, trends and issues in medicinal chemistry, and legal matters like patent law and regulation.<ref name=CEN2006>{{cite news|last1=Raber|first1=Linda R.|title=Moving Away From Target-Based Discovery|url=https://cen.acs.org/articles/84/web/2006/06/Moving-Away-Target-Based-Discovery.html|work=Chemical & Engineering News|date=June 19, 2006}}</ref> At that time he was working at a pharmaceutical company doing hit to lead medicinal chemistry work.<ref name=CEN2006/> {{as of|2010}} his blog received between 15,000 and 20,000 page views on a typical weekday.<ref name=Jarvis>{{cite news|last1=Jarvis|first1=Lisa|title=Pharma Blogging Panel at ACS Boston|url=http://cenblog.org/the-haystack/2010/08/pharma-blogging-panel-at-acs-boston/-haystack/2010/08/pharma-blogging-panel-at-acs-bosto|work=The Haystack|date=24 August 2010}}</ref> His response to a 2013 article in BuzzFeed that propagated chemophobia was widely cited.<ref>{{cite news|title=Foods Ingredients Banned Outside the US|url=https://abcnews.go.com/Lifestyle/Food/11-foods-banned-us/story?id=19457237|work=ABC News|date=26 June 2013|language=en}}</ref><ref>{{cite news|last1=Nosowitz|first1=Dan|title=Chemist Says BuzzFeed Article About Food Chemistry Has "Serial Stupidities"|url=https://www.popsci.com/science/article/2013-06/chemist-says-buzzfeed-article-about-food-chemistry-has-serial-stupidities|work=Popular Science|date=June 21, 2013|language=en}}</ref><ref>{{cite news|last1=Jogalekar|first1=Ashutosh|title=Where's the chemistry lobby? On why we need a National Center for Chemical Education|url=https://blogs.scientificamerican.com/the-curious-wavefunction/wheres-the-chemistry-lobby-on-why-we-need-a-national-center-for-chemical-education/|work=Scientific American Blog Network|date=July 11, 2013|language=en}}</ref>
He serves on the editorial board of ''ACS Medicinal Chemistry Letters'' and on the advisory board of ''Chemical & Engineering News''.<ref>{{cite journal|last1=Baum|first1=Rudy M.|title=C&EN In The Blogosphere|journal=Chemical & Engineering News|date=3 May 2010|volume=88|issue=18|pages=3|doi=10.1021/cen-v088n018.p003|doi-access=free}}</ref>
{{as of|2018}} he was working at Novartis; formerly he had worked for 10 years at Vertex, 9 years at Bayer, and 8 years at Schering-Plough.<ref name=linkedin>{{cite web|title=Derek Lowe|url=https://www.linkedin.com/in/dereklowe|publisher=LinkedIn|access-date=29 May 2018}}</ref><ref>{{cite news|last1=Lieu|first1=Chris|title=BioCentury - Lowe parts ways with Vertex amid reorganization|url=https://www.biocentury.com/bc-extra/company-news/2017-03-28/lowe-parts-ways-vertex-amid-reorganization|work=Biocentury|date=28 March 2017|language=en}}</ref><ref>{{cite journal|last1=Chemjobber|title=Layoffs and the midcareer chemist|journal=Chemical & Engineering News|date=November 20, 2017|volume=95|issue=46|url=https://cen.acs.org/articles/95/i46/Layoffs-midcareer-chemist.html}}</ref>
== Notable publications == === Book === *{{cite book|last1=Lowe|first1=Derek B.|title=The Chemistry Book: From Gunpowder to Graphene, 250 Milestones in the History of Chemistry |date=2016|publisher=Sterling|isbn=9781454911807|language=en}}
=== Selected scientific papers === *{{cite journal|last1=Greenlee|first1=W|last2=Clader|first2=J|last3=Asberom|first3=T|last4=McCombie|first4=S|last5=Ford|first5=J|last6=Guzik|first6=H|last7=Kozlowski|first7=J|last8=Li|first8=S|last9=Liu|first9=C|last10=Lowe|first10=D|last11=Vice|first11=S|last12=Zhao|first12=H|last13=Zhou|first13=G|last14=Billard|first14=W|last15=Binch|first15=H|last16=Crosby|first16=R|last17=Duffy|first17=R|last18=Lachowicz|first18=J|last19=Coffin|first19=V|last20=Watkins|first20=R|last21=Ruperto|first21=V|last22=Strader|first22=C|last23=Taylor|first23=L|last24=Cox|first24=K|title=Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.|journal=Farmaco |date=April 2001|volume=56|issue=4|pages=247–50|pmid=11421251|display-authors=2|doi=10.1016/s0014-827x(01)01102-8}} *{{cite journal|last1=Lowe|first1=DB|last2=Magnuson|first2=S|last3=Qi|first3=N|last4=Campbell|first4=AM|last5=Cook|first5=J|last6=Hong|first6=Z|last7=Wang|first7=M|last8=Rodriguez|first8=M|last9=Achebe|first9=F|last10=Kluender|first10=H|last11=Wong|first11=WC|last12=Bullock|first12=WH|last13=Salhanick|first13=AI|last14=Witman-Jones|first14=T|last15=Bowling|first15=ME|last16=Keiper|first16=C|last17=Clairmont|first17=KB|title=In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.|journal=Bioorganic & Medicinal Chemistry Letters|date=21 June 2004|volume=14|issue=12|pages=3155–9|doi=10.1016/j.bmcl.2004.04.015|pmid=15149665|display-authors=2}} * {{cite journal|last1=Rudolph|first1=J|last2=Esler|first2=WP|last3=O'connor|first3=S|last4=Coish|first4=PD|last5=Wickens|first5=PL|last6=Brands|first6=M|last7=Bierer|first7=DE|last8=Bloomquist|first8=BT|last9=Bondar|first9=G|last10=Chen|first10=L|last11=Chuang|first11=CY|last12=Claus|first12=TH|last13=Fathi|first13=Z|last14=Fu|first14=W|last15=Khire|first15=UR|last16=Kristie|first16=JA|last17=Liu|first17=XG|last18=Lowe|first18=DB|last19=McClure|first19=AC|last20=Michels|first20=M|last21=Ortiz|first21=AA|last22=Ramsden|first22=PD|last23=Schoenleber|first23=RW|last24=Shelekhin|first24=TE|last25=Vakalopoulos|first25=A|last26=Tang|first26=W|last27=Wang|first27=L|last28=Yi|first28=L|last29=Gardell|first29=SJ|last30=Livingston|first30=JN|last31=Sweet|first31=LJ|last32=Bullock|first32=WH|title=Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.|journal=Journal of Medicinal Chemistry|date=18 October 2007|volume=50|issue=21|pages=5202–16|doi=10.1021/jm070071+|pmid=17887659|display-authors=2}} *{{cite journal|last1=Arrowsmith|first1=CH|last2=Audia|first2=JE|last3=Austin|first3=C|last4=Baell|first4=J|last5=Bennett|first5=J|last6=Blagg|first6=J|last7=Bountra|first7=C|last8=Brennan|first8=PE|last9=Brown|first9=PJ|last10=Bunnage|first10=ME|last11=Buser-Doepner|first11=C|last12=Campbell|first12=RM|last13=Carter|first13=AJ|last14=Cohen|first14=P|last15=Copeland|first15=RA|last16=Cravatt|first16=B|last17=Dahlin|first17=JL|last18=Dhanak|first18=D|last19=Edwards|first19=AM|last20=Frederiksen|first20=M|last21=Frye|first21=SV|last22=Gray|first22=N|last23=Grimshaw|first23=CE|last24=Hepworth|first24=D|last25=Howe|first25=T|last26=Huber|first26=KV|last27=Jin|first27=J|last28=Knapp|first28=S|last29=Kotz|first29=JD|last30=Kruger|first30=RG|last31=Lowe|first31=D|last32=Mader|first32=MM|last33=Marsden|first33=B|last34=Mueller-Fahrnow|first34=A|last35=Müller|first35=S|last36=O'Hagan|first36=RC|last37=Overington|first37=JP|last38=Owen|first38=DR|last39=Rosenberg|first39=SH|last40=Roth|first40=B|last41=Ross|first41=R|last42=Schapira|first42=M|last43=Schreiber|first43=SL|last44=Shoichet|first44=B|last45=Sundström|first45=M|last46=Superti-Furga|first46=G|last47=Taunton|first47=J|last48=Toledo-Sherman|first48=L|last49=Walpole|first49=C|last50=Walters|first50=MA|last51=Willson|first51=TM|last52=Workman|first52=P|last53=Young|first53=RN|last54=Zuercher|first54=WJ|title=The promise and peril of chemical probes.|journal=Nature Chemical Biology|date=August 2015|volume=11|issue=8|pages=536–41|doi=10.1038/nchembio.1867|pmid=26196764|pmc=4706458|display-authors=2}}
=== Selected blogs or commentary === * {{cite web|last1=Lowe|first1=Derek|title=The Latest Thing|url=https://www.science.org/content/blog-post/latest-thing|website=In the Pipeline|date=7 February 2002}} (1st post) * {{cite journal|last1=Lowe|first1=Derek|title=Molecular modelling's $10-million comeback?|journal=Nature|date=7 May 2010|doi=10.1038/news.2010.223}} * {{cite news|last1=Lowe|first1=Derek|title=Things I Won't Work With: Dioxygen Difluoride|url=https://www.science.org/content/blog-post/things-i-won-t-work-dioxygen-difluoride|work=In the Pipeline|date=23 February 2010}} Cited in {{cite web|title=Pressure Cooker|url=https://what-if.xkcd.com/40/|publisher=What-if xkcd|date=April 9, 2013}} *{{cite news|last1=Lowe|first1=Derek|title=Avandia Goes Down: A Research Rant|url=https://www.science.org/content/blog-post/avandia-goes-down-research-rant|work=In the Pipeline|date=24 September 2010}} * {{cite news|last1=Lowe|first1=Derek|title=Eight Toxic Foods: A Little Chemical Education|url=https://www.science.org/content/blog-post/eight-toxic-foods-little-chemical-education|work=In the Pipeline|date=21 June 2013}}, {{cite news|title=Eight Toxic Foods: The Aftermath|url=https://www.science.org/content/blog-post/eight-toxic-foods-aftermath|work=In the Pipeline|date=24 June 2013}} * {{cite news|last1=Lowe|first1=Derek|title=Drug Mergers Hurt in Every Direction (Save One)|url=https://www.science.org/content/blog-post/drug-mergers-hurt-every-direction-save-one|work=In the Pipeline|date=24 August 2016}} * {{cite news|last1=Lowe|first1=Derek|title=Curcumin Will Waste Your Time|url=https://www.science.org/content/blog-post/curcumin-will-waste-your-time|work=In the Pipeline|date=12 January 2017|access-date=29 May 2018|archive-url=https://web.archive.org/web/20190406173250/http://blogs.sciencemag.org/pipeline/archives/2017/01/12/curcumin-will-waste-your-time|archive-date=6 April 2019|url-status=live}} *{{cite news|last1=Lowe|first1=Derek|title=Objections to (Some) Drug Discovery AI|url=https://www.science.org/content/blog-post/objections-some-drug-discovery-ai|work=In the Pipeline|date=10 January 2018}}
== References == {{reflist}}
== External links == *Lowe's "[https://www.science.org/blogs/pipeline In the Pipeline]" blog * {{cite web|url=https://www.chemistryworld.com/derek-lowe/1605.more|title=Derek Lowe|publisher=Chemistry World|language=en-US|url-status=dead|archive-date=January 8, 2023|archive-url=https://web.archive.org/web/20230108102053/https://www.chemistryworld.com/derek-lowe/1605.more}} *{{cite journal|last1=Lowe|first1=D|title=An interview with Derek Lowe.|journal=Trends in Pharmacological Sciences|date=March 2013|volume=34|issue=3|pages=147–8|doi=10.1016/j.tips.2013.01.003|pmid=23462513}} *{{cite news|title=Interview: Derek Lowe|url=http://blogs.nature.com/thescepticalchymist/2007/05/reactions_derek_lowe_1.html|work=The Sceptical Chymist: A Nature Chemistry blog|date=18 May 2007|access-date=1 August 2010|archive-date=4 July 2008|archive-url=https://web.archive.org/web/20080704192733/http://blogs.nature.com/thescepticalchymist/2007/05/reactions_derek_lowe_1.html|url-status=dead}} *[https://www.reddit.com/r/science/comments/1z6o2d/science_ama_series_im_derek_lowe_medicinal/ Reddit AMA], 28 February 2014
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{{DEFAULTSORT:Lowe, Derek}} Category:American science bloggers Category:21st-century American chemists Category:Drug discovery Category:Hendrix College alumni Category:Duke University alumni Category:Living people Category:People from Harrisburg, Arkansas Category:Year of birth missing (living people) Category:21st-century American science writers