'''De Soto''' commonly refers to
* Hernando de Soto (c. 1500 – 1542), Spanish explorer * DeSoto (automobile), an American automobile brand from 1928 to 1961
'''De Soto''', '''DeSoto''', '''Desoto''', or '''de Soto''' may also refer to: {{TOC right}}
== Places in the United States of America == ;Populated places * De Soto, Georgia * De Soto, Illinois * De Soto, Iowa * De Soto, Kansas * De Soto, Mississippi * De Soto, Missouri * De Soto, Nebraska * De Soto, Wisconsin * DeSoto, Indiana * DeSoto, Texas, the most populous De Soto in the US
;Administrative divisions * De Soto Parish, Louisiana * DeSoto County, Florida * DeSoto County, Mississippi
;Parks and geographic features * De Soto National Forest in Mississippi * DeSoto Falls (Alabama) * DeSoto Falls (Georgia) * DeSoto Lake, a lake in Georgia * DeSoto National Wildlife Refuge, in Nebraska and Iowa * Fort De Soto Park in St. Petersburg, Florida * De Soto National Memorial in Bradenton, Florida * DeSoto Site Historic State Park in Tallahassee, Florida
== People == * de Soto (surname) == Other uses == *The DeSoto, historic hotel in Savannah, Georgia * DESOTO patrols, conducted by the U.S. Navy to collect signals intelligence in hostile waters * DeSoto Records, a record label * USS De Soto County (LST-1171), a post-war Landing Ship Tank of the US Navy * De Soto station, Los Angeles * De Soto Avenue, Los Angeles
== See also == *Soto (disambiguation)
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